Synephrine-hydrochloride-Oxedrine-hydrochloride-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESynephrine hydrochlorideCat. No.: HY-N0132ACAS No.: 5985-28-4Synonyms: Oxedrine hydrochloride分式: CHClNO分量: 203.67作靶點: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 52 mg/mL (255.31 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.9099 mL 24.5495 mL 49.0990 mL5 mM 0.9820 mL 4.9099 mL 9.8198 mL10 mM 0.4910 mL 2.4550 mL 4.9099 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL

3、 ACTIVITY物活性 Synephrine hydrochloride (Oxedrine hydrochloride)物堿，是腎上腺素受體激動劑。IC50 & Target Adrenergic receptor 1體外研究There is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemETAAR1 (trace adrenergic amine

4、 receptors). d-synephrine inhibited the uptake of 3H-norepinephrine with anIC50 = 5.8 M; l-synephrine was less potent (IC50 = 13.5 M). d-Synephrine also competitively inhibited thebinding of nisoxetinem to rat brain cortical slices, with a Ki = 4.5 M; l-synephrine was less potent (Ki = 8.2M). In exp

5、eriments on the release of 3H-norepinephrine from rat brain cortical slices, however, the l-isomerof synephrine was a more potent enhancer of the release (EC50 = 8.2 M) than the d-isomer (EC50 = 12.3 M). This enhanced release by l-synephrine was blocked by nisoxetine.REFERENCES1. Synephrine, From WikipediaMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021