Triamcinolone-hexacetonide-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETriamcinolone hexacetonideCat. No.: HY-U00103CAS No.: 5611-51-8分式: CHFO分量: 532.64作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 41.67 mg/mL (78.23 mM; Need ultrasonic

2、)H2O : 90% corn oilSolubility: 2.08 mg/mL (3.91 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Triamcinolone hexacetonide種常的長效類 醇，于治療亞急性和慢性炎性關(guān)節(jié)疾病。體內(nèi)研究 Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically

3、induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much lessprominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolonehexacetonide into the ipsilateral knee of rabbits which have been subjected to partial latera

4、l meniscectomy andtransection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells,osteophyte formation, and fibrillation 1. The half-life of commercially available Triamcinolone hexacetonide inthe vitreous is double that of Triamcinolone hexacetonide, but the

5、former is toxic to the retina in this rabbitmodel. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects toretina function or structure 2. Local application of Triamcinolone hexacetonide at a site of lingual nerve injuryleads to changes that are potentially ben

6、eficial such as reduced mechanical sensitivity and enhancedregeneration 3.PROTOCOLAnimal Guinea pigs: Animals are given intraarticular injection of 0.1 mL of Triamcinolone hexacetonide provided aAdministration 1 dose of 0.40 mg/kg (groups 2 and 3) or 0.04 mg/kg (groups 4 and 5). The volume of CMC in

7、jected into theknees of group 6 animals is the same as that used for the intraarticular injections in the other groups, i.e., 0.1mL. When the animals are killed, both knees are immediately opened and examined grossly 1.MCE has not independently confirmed the accuracy of these methods. They are for r

8、eference only.REFERENCES1. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically inducedarticular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.2. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexac

9、etonide in rabbit eyes. J Ocul Pharmacol Ther. 2008Apr;24(2):197-205.3. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge followinglingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9.McePdfHeightCaution: Product has not been fully validated for medical