SB-334867-free-base-SB334867A-free-base-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESB-334867 free baseCat. No.: HY-10895ACAS No.: 792173-99-0Synonyms: SB334867A free base分式: CHNO分量: 319.32作靶點(diǎn): Orexin Receptor (OX Receptor)作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C

2、6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 49 mg/mL (153.45 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.83 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.83 mM); Suspended solution; Need u

3、ltrasonic3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 SB-334867游離堿肽類欲肽OX1受體拮抗劑，pKb為7.2。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Front Neurosci. 2016 Jul 26;10:355.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Smart D, et al. SB-334867-A: the fir

4、st selective orexin-1 receptor antagonist. Br J Pharmacol. 2001 Mar;132(6):1179-82.2. Rasmussen K, et al. The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10dopamine neurons: implications for antipsychotic therapy. Neuropsychopharmacology. 20

5、07 Apr;32(4):786-92.3. Azhdari-Zarmehri H, et al. Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalintest. Pharmacol Biochem Behav. 2013 Nov;112:64-70.4. Rodgers RJ, et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effectof orexin-A in rats. Eur J Neurosci. 2001 Apr;13(7):1444-52.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792