BRL-54443 - 5-HT Receptor Agonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBRL 54443Cat. No.: HY-13221CAS No.: 57477-39-1分式: CHNO分量: 230.31作靶點(diǎn): 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 51 mg/mL (221.44 mM)

2、* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.3420 mL 21.7099 mL 43.4197 mL5 mM 0.8684 mL 4.3420 mL 8.6839 mL10 mM 0.4342 mL 2.1710 mL 4.3420 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 BRL 544435-HT1E/1F受體激動(dòng)劑，pKi分別為8.7和8.9，對其它5

3、-HT和多巴胺受體的抑制性30倍以上。REFERENCES1. Klein MT, et al. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-867.1/2 Master of Small Molecules 您邊的抑制

4、劑師www.MedChemE2. McKune CM, et al. Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathwaycoupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95.3. Klein MT, et al. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculatu

5、re: an immunohistochemical andpharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302.4. Granados-Soto V, et al. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction ofnociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021