Flavin-Adenine-Dinucleotide-Disodium-FAD-Na2-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFlavin Adenine Dinucleotide DisodiumCat. No.: HY-B1654ACAS No.: 84366-81-4Synonyms: FAD-Na2; FAD sodium salt分式: CHNNaOP分量: 829.51作靶點(diǎn): Others作通路: Others儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (prot

2、ect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 125 mg/mL (150.69 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.2055 mL 6.0277 mL 12.0553 mL5 mM 0.2411 mL 1.2055 mL 2.4111 mL10 mM 0.1206 mL 0.6028 mL 1.2055 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Flavin Adenine

3、Dinucleotide Disodium種氧化還原輔因，蛋質(zhì)的輔 ，在代謝過(guò)程中參與了個(gè)重要的酶反應(yīng)。體外研究Poly(Flavin Adenine Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is ahighly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADHtransducers (0.00 V, pH 7.4), poly(FA

4、D) is characterized by the electrochemical rate constant of 1.8 0.610-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEcharacterized by the dramatically improved stability and, is the most advantageous

5、 NADH transducers foranalytical chemistry 2.體內(nèi)研究 With flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricularfibrillation threshold (VFT) is significantly cancelled. Flavin Adenine Dinucleotide cancels the effect of CPZ oncanine heart mitochondria. After injec

6、tion of Flavin Adenine Dinucleotide, the dogs show a transienthypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenine Dinucleotidealso prevents mitochondrial dysfunction induced by chlorpromazine 1.REFERENCES1. Sugiyama S, et al. Protection of chlorpromazin

7、e-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979Sep;20(5):657-65.2. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr1;76(7):2004-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use