Ro-46-2005 - Endothelin Receptor Antagonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 46-2005Cat. No.: HY-19529CAS No.: 150725-87-4分式: CHNOS分量: 473.54作靶點(diǎn): Endothelin Receptor作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 28 mg/mL (59.13 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1118 mL 10.5588 mL 21.1175 mL5 mM 0.4224 mL 2.1118 mL 4.2235 mL10 mM 0.2112 mL 1.0559 mL 2.1118 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ro 46-2005種新型肽類內(nèi)素拮抗劑, 抑制管平滑肌細(xì)胞(ETA受體), IC50分別為220 nM。R

3、EFERENCES1. Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors.FEBS Lett. 1993 Nov 15;334(2):210-214.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Clozel M, et al. Pathophysiological role of endothelin revealed by

4、 the first orally active endothelin receptor antagonist. Nature. 1993 Oct21;365(6448):759-761.3. N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue WaterDiffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: