Lopinavir-ABT-378-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELopinavirCat. No.: HY-14588CAS No.: 192725-17-0Synonyms: ABT-378分式: CHNO分量: 628.8作靶點(diǎn): HIV; HIV Protease作通路: Anti-infection; Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn)

2、 DMSO : 100 mg/mL (159.03 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.5903 mL 7.9517 mL 15.9033 mL5 mM 0.3181 mL 1.5903 mL 3.1807 mL10 mM 0.1590 mL 0.7952 mL 1.5903 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠

3、性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (3.98 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (3.98 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChe

4、mEBIOLOGICAL ACTIVITY物活性 Lopinavir親和性HIV蛋酶抑制劑，Ki為1.3 pM。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Biochem Biophys Res Commun. 2019 Sep 10;517(1):125-131. Faculty of Pharmacy in Hradec Krlov Department of Pharmacological and Toxicology. University of Oxford. 2019 Jul.See more customer validations on HYPERLINK / www.MedChemEREFERE

5、NCES1. Vishnuvardhan, D., et al., Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein. AIDS, 2003.17(7): p. 1092-4.2. Gonzalez, L.M., et al., In vitro hypersusceptibility of human immunodeficiency virus type 1 subtype C protease to lopinavir. AntimicrobAgents

6、Chemother, 2003. 47(9): p. 2817-22.3. Weemhoff, J.L., et al., Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. J Pharm Pharmacol, 2003. 55(3): p.381-6.4. Sham, H.L., et al., ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother,1998. 42(12): p. 3218-24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: