Tropisetron-Hydrochloride-SDZ-ICS-930-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETropisetron HydrochlorideCat. No.: HY-B0020CAS No.: 105826-92-4Synonyms: SDZ-ICS-930分式: CHClNO分量: 320.81作靶點(diǎn): 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mo

2、nth溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 50 mg/mL (155.86 mM)DMSO : 33.33 mg/mL (103.89 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1171 mL 15.5855 mL 31.1711 mL5 mM 0.6234 mL 3.1171 mL 6.2342 mL10 mM 0.3117 mL 1.5586 mL 3.1171 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑

3、配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Tropisetron Hydrochloride (SDZ-ICS-930)是5-HT3受體拮抗劑和7-煙堿受體激動(dòng)劑，對(duì)5-HT3受體的IC50為70.1 nM。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Int J Neuropsychopharmacol. 2019 May 24. pii: pyz023.See more customer validations on HYPERLINK / www.MedChemERE

4、FERENCES1. Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013Oct;43(10):1039-51.2. Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action.Neuropharmac

5、ology. 2013 Oct;73:111-21.3. Aminian A, et al. Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience.2013 Jun 15;248C:299-306.4. Rahimian R, et al. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin.Brain Res. 2011 Oct 12;1417:1-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;