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1、第 魔芋葡甘聚糖和殼聚糖-185. :/ erchains(-NH3+)ontheiractivefunctionalsurface17.Fulvicacidwiththree-dimensionalnetwork,whicharecross-linked(FA),asananionicorganiccompound,iseconomicalandbyhydrogenbonding,physicalentanglementsorcovalentubiquitous18.Itisproducedbyorganicmaterial(i.e.plantsbonds1.Hydrogelshavebee

2、ntremendouslyusedintheandmicroorganisms)degradation,andhasbeenconsidereddevelopmentofcontrolled-releaseandsustained-releasedrugtobestableunderalkalineandacidicenvironment19.The2-3deliverysystemssincetheycouldnotonlyprotectthedrugchitosan-fulvicacidmicroparticles(CFMPs)werefabricatedfromhostileenviro

3、nmentsfortheslowreleasebydiffusionviatheelectrostaticself-assemblyapproach.Itcouldbeusedorerosion,butalsoexhibitlargereversibledeformationsasanaturalreinforcingagentofbiopolymerwithhighertriggeredbyenvironmentalchangesinpH,temperature,electricsurfacesitedensityandoxygen-containingfunctionalgroups,1a

4、ndmagneticfields.Nevertheless,onemajorchallengeofsuchashydroxyl(-OH),carboxyl(-COOH)andphenolichydrogelsisfabricatingcompactnetworkhydrogelswithout(-Ph-OH)20-21.Tothebestofourknowledge,nostudycompromisingtheirswellingcharacteristics4.hasbeenconductedontheKGMcompositehydrogelusingKonjacglucomannan(KG

5、M)isahighmolecular-weightCFMPsasareinforcingagent.Herein,KGM/CFMPscompositehydrogelwereneutralpolysaccharideextractedfromthetubersofthe5Amorphaphalluskonjacplants.ItismainlycomposedoffabricatedusingCFMPsasthereinforcingagent.The-1,4linkedD-mannoseandD-glucosewithacetylgroupsinfluencesofCFMPsonthenet

6、workstructureofKGM/attachedrandomlytoC6position6.KGMhasdemonstratedCFMPscompositehydrogelswerestudied.Ofloxacingreatpotentialinhydrogelapplicationduetoexcellent(modeldrug)loadingefficiencies(DLEs)andencapsulationbiocompatibility,biodegradability,gelling,andswellingefficiencies(EEs)ofthehydrogels,and

7、ofloxacinrelease5,7.IthasbeenfoundthatKGMcouldonlybebehaviorindifferentmediumswerealsoevaluated.ItishydrolyzedbycolonicbacterialenzymeswhilenotbeingpresumedthatCFMPscouldnotonlyimprovethestructuredegradedinthegastrointestinaltract,thusithasattractedofKGMhydrogels,butalsoimprovetheirpH-responsiveprop

8、ertiesmuchattentionforpromisingapplicationindrugdelivery5,8.releasecharacteristic.However,theapplicationofneatKGMhydrogelindrugsreleasehasbeenseriouslyrestrictedduetoitsweaknetworkstructure9-101MaterialsandMethods.Consequently,manystrategiesarebeingexploredtoimprovetheefficiencyofKGMhydrogelsindrugsdeliverysystems,suchasphysicaltreatment11-12,1.1MaterialsandreagentsRecently,microparticles(MPs)withdistinctiveKGM(purity95%;viscosity:35000Pasat25,1%solution(m/m)waspurchasedfromSanaiKonjacDevelopmentCo.(Yunnan,China).CSwaspurchasedfromcharacterizations(suchashighsurfacearea,nano-scaledsiz

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