AV-153-free-base-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAV-153 free baseCat. No.: HY-135218ACAS No.: 19350-66-4分式: CHNO分量: 297.3作靶點: DNA/RNA Synthesis作通路: Cell Cycle/DNA Damage儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 250 mg/mL (840.90 mM;

2、 Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.3636 mL 16.8180 mL 33.6361 mL5 mM 0.6727 mL 3.3636 mL 6.7272 mL10 mM 0.3364 mL 1.6818 mL 3.3636 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根

3、據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.00 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.00 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 AV-1

4、53 free base種 1,4-dihydropyridine (1,4-DHP) 衍物，具有抗突變作。在體外細(xì)胞內(nèi)，AV-153free base 可以插到 DNA 的單鏈斷裂處，減少 DNA 損傷并刺激 DNA 修復(fù)。AV-153 free base 可以與胸腺嘧啶和胞嘧啶相互作，對聚 (ADP) 核糖化有響。AV-153 free base 具有抗癌活性。體外研究 AV-153 free base causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively 1.AV-153 free base

5、(1 nM to 10 M; 3 hours) reduces the level of spontaneously arising DNA single-strandbreaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 1367% 1.REFERENCES1. Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells inVitro. M

6、utat Res. 2005 Nov 10;587(1-2):52-8.2. E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. ChemBiol Interact. 2014 Sep 5;220:200-7.3. Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-LikeCells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te