Acriflavine-hydrochloride-Acriflavinium-chloride-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAcriflavinehydrochlorideCat.No.:HY-W088075CASNo.:69235-50-3Synonyms:Acriflaviniumchloridehydrochloride分?式:C??H??Cl?N?分?量:541.9作?靶點(diǎn):HIF/HIFProlyl-Hydroxylase;Bacterial;SARS-CoV作?通路:MetabolicEnzyme/Protease;Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:25mg/mL(46.13mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.8454mL9.2268mL18.4536mL5mM0.3691mL1.8454mL3.6907mL10mM0.1845mL0.9227mL1.8454mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:2.5mg/mL(4.61mM);Suspendedsolution;Needultrasonic2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(4.61mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性Acriflavinehydrochloride(Acriflaviniumchloridehydrochloride)?種熒光吖啶染料，可?于標(biāo)記核酸。Acriflavinehydrochloride?種防腐劑。Acriflavinehydrochloride?種?效的HIF-1抑制劑，具有抗腫瘤活性。Acriflavinehydrochloride具有抗和抗病毒活性。Acriflavinehydrochloride?種PLpro抑制劑，能抑制SARS-CoV-2。戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?EBioMedicine.2019Nov;49:291-304.?EBioMedicine.2018May;31:202-216.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].LMChan,etal.InteractionofacriflavinewithDNAandRNA.JMolBiol.1969Mar28;40(3):491-5.[2].ThomasMeinelt,etal.EffectsofCalciumContentandHumicSubstancesontheToxicityofAcriflavinetoJuvenileZebrafishDaniorerio.JournalofAquaticAnimalHealth,14:1,35-38.[3].TaoYin,etal.HIF-1DimerizationInhibitorAcriflavineEnhancesAntitumorActivityofSunitinibinBreastCancerModel.OncolRes.2015;22(3):139-145.[4].RománMartí-Díaz,etal.Acriflavine,aPotentInhibitorofHIF-1α,DisturbsGlucoseMetabolismandSuppressesATF4-ProtectivePathwaysinMelanomaunderNon-HypoxicConditions.Cancers(Basel).2021Jan;13(1):102.[5].YoshihiroShimoji,etal.Aputativetranscriptionregulatorinvolvedinthevirulenceattenuationofanacriflavine-resistantvaccinestrainofErysipelothrixrhusiopathiae,thecausativeagentofswineerysipelas.VetMicrobiol.2019Dec;239:108488.[6].ValeriaNapolitano,etal.Acriflavine,aclinicallyaproveddrug,inhibitsSARS-CoV-2andotherbetacoronaviruses.bioRxiv2021.03.20.436259.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappl