目前國(guó)際最新制劑發(fā)展動(dòng)態(tài)及加工關(guān)鍵技術(shù)介紹-先正達(dá)課件

AgrochemicalFormulationTrends

農(nóng)藥制劑的發(fā)展趨勢(shì)CCPIAGuilin,Guangxi,China中國(guó)–桂林KeithParker,Ph.D.SyngentaAsiaPacificPte.Ltd.AgrochemicalFormulationTrendWhoisSyngenta

先正達(dá)介紹AgrochemicalFormulationTrends

農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents內(nèi)容WhoisSyngenta

先正達(dá)介紹ContentsOurindustryfamilytree國(guó)際農(nóng)化公司發(fā)展概況CibaSandozICIISKBiosciencesMonsantoDuPontShellCyanamidBASFBayerRhone-PoulencHoechstScheringDowRohm&HaasMerck1992199319941995199619971998199920002001NovartisAHPAventis2002AgrevoZenecaOurindustryfamilytree國(guó)際農(nóng)化公Excellentcomplementaryandleadingproductportfolio

卓越全面、領(lǐng)先的產(chǎn)品線Aleaderincropprotection植保領(lǐng)域的領(lǐng)先者Thirdinhigh-valuecommercialseeds高價(jià)值商業(yè)種子排名第三Firstclassresearchanddevelopmentresources一流的研發(fā)資源

Investmentofaround$800mannually

每年投入約八億美元Strongworldwidepresence

業(yè)務(wù)遍布全球Around21,000employeesinover90countries在90多個(gè)國(guó)家擁有2萬(wàn)1千名雇員RichpipelineofCropProtectionandSeedsproducts

豐富的植保和種子產(chǎn)品產(chǎn)銷(xiāo)渠道Syngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司ExcellentcomplementaryandleSyngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司

milliontonnesofcottonisgrownusingourcropprotectionproducts

全球440萬(wàn)噸棉花種植過(guò)程中使用先正達(dá)植保產(chǎn)品

That’stheequivalentof20billionT-Shirts

這相當(dāng)于200億件T恤的用料4.4Syngenta–aleadingglobalagSyngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司70%

ofScotchWhiskyisproducedbySyngentabarley70%蘇格蘭威士忌是用先正達(dá)大麥制造的Syngenta–aleadingglobalagWhatWeDo

我們從事哪些業(yè)務(wù)CropProtection

作物保護(hù)Seeds

種子

ProfessionalProducts

專(zhuān)業(yè)產(chǎn)品

Bio-technology

生物技術(shù)

WhatWeDo我們從事哪些業(yè)務(wù)CropSeeds

Majorproductbrands主要的產(chǎn)品品牌Herbicides

除草劑Professionalproducts

專(zhuān)業(yè)產(chǎn)品Fungicides

殺菌劑Insecticides

殺蟲(chóng)劑Seeds

種子阿克泰金雷世高阿米西達(dá)銳勝泰草達(dá)克無(wú)蹤功夫千層紅Majorproductbrands主要的產(chǎn)品品牌HeRank

排名2006R&Dspend

2006

研發(fā)投入$m1 Syngenta先正達(dá)

2 Bayer拜爾4 BASF巴斯夫5

DuPont

杜邦3

Monsanto

孟山都6 Dow

陶氏As%ofSales

銷(xiāo)售百分比％11%10%10%14%

11%10%Theleaderinresearchanddevelopment

先正達(dá)，研究與開(kāi)發(fā)的領(lǐng)導(dǎo)者Source:PhillipsMcDougall,SyngentaRank

排名2006R&Dspend

2006研發(fā)投MajorR&Dsites

locatedatthe

heartofscientificcommunitiesOthersitesMarker-assistedandseedbreedingcapabilitiesGlobalfieldstationnetworkGlobalR&Dcapabilities全球研發(fā)機(jī)構(gòu)美國(guó)格林斯博羅GREENSBOROFormulationEnvironmentalScience美國(guó)SBIBiotechnologyR&D英國(guó)集能山JEALOTT’SHILLChemicalDiscoveryWeedControlFormulationBioscienceEnvironmentalScience瑞士巴塞爾/斯坦恩BASEL/STEINFungicides,Insecticides&ProfessionalProducts印度果阿GOAChemistryMajorR&Dsites

locatedatthSyngentainChina先正達(dá)在中國(guó)CropProtection

作物保護(hù)Seeds

種子

ProfessionalProducts

專(zhuān)業(yè)產(chǎn)品R&D

研發(fā)SyngentainChina先正達(dá)在中國(guó)CropSAhistoryofmorethan100years

百多年合作歷史AssociatedinvestmentUS$200m目前總投資達(dá)2億美元

40%ofthetotaldirectforeigninvestmentinCPsection投資額占中國(guó)市場(chǎng)植保領(lǐng)域外商直接投資的40％InvestmentinChina

先正達(dá)在中國(guó)的投資Syngenta(Suzhou)CropProtectionCo.,Ltd.SyngentaSeeds

CompanyLtd.SyngentaNantongCropProtectionCo.,Ltd.Ahistoryofmorethan100yeaEnvironmentProtectionResponsibilityinChina

先正達(dá)在中國(guó)環(huán)保社會(huì)責(zé)任“Top100EnvironmentalFriendlyProjects”byStateEnvironmentalProtectionAdministration“—theonlyoneofitskindincropprotectionindustry“

國(guó)家環(huán)保局授予的“百佳環(huán)保工程”榮譽(yù)稱號(hào)－植保行業(yè)中唯一獲此殊榮

“Top10environmentalfriendlyenterprises”“江蘇省十大環(huán)保企業(yè)”

“High-techenterprises”inJiangsuprovince”“江蘇省高新技術(shù)企業(yè)”

Providetechnicalsupportforindustry/nationalstandardssetup

為行業(yè)標(biāo)準(zhǔn)設(shè)定提供技術(shù)支持

EnvironmentProtectionResponsChina’ssustainableagriculturedevelopmentthroughinnovativeresearchandtechnology

通過(guò)創(chuàng)新性的研究和技術(shù)，中國(guó)農(nóng)業(yè)的可持續(xù)性發(fā)展Improvecropproductivity,qualityandsafetythroughintegratedsolutions

通過(guò)完整的方案，提高和改善作物產(chǎn)量，質(zhì)量和安全性UpgradeChinesefarmer’sincomeandthequalityoflife

提升中國(guó)農(nóng)民的收入和生活質(zhì)量SyngentaChinaisCommittedTo

先正達(dá)中國(guó)忠于..China’ssustainableagriculturWhoisSyngenta

先正達(dá)介紹AgrochemicalFormulationTrends

農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents內(nèi)容WhoisSyngenta

先正達(dá)介紹ContentsFormulationTechnology制劑技術(shù)AgribusinessinvestsheavilyinFormulationScience

在制劑技術(shù)的上開(kāi)發(fā)上，農(nóng)化企業(yè)投入重金B(yǎng)othforfirstlaunchofnewActiveIngredientsandproductlife-cyclemanagement對(duì)新開(kāi)發(fā)的原藥及老的原藥在制劑技術(shù)上都會(huì)投入重金Why?

為什么？FormulationTechnology制劑技術(shù)AgrWhyFormulation?為什么要制成制劑使用？ActiveIngredientsdon’twork….

原藥本身沒(méi)有藥效…………..Untiltheyaremadeintoformulations

……除非原藥被做成制劑后使用

Ourcustomersbuyformulatedproductsinpacks我們的客戶購(gòu)買(mǎi)的是包裝好的農(nóng)藥制劑產(chǎn)品Solutions溶液Emulsions乳液Suspensions懸浮液Solids固體Capsules膠囊WhyFormulation?為什么要制成制劑使用？AcUntreated沒(méi)有使用過(guò)農(nóng)藥Untreated沒(méi)有使用過(guò)農(nóng)藥Un-FormulatedHerbicide

未經(jīng)制劑加工的除草劑Un-FormulatedHerbicide未經(jīng)制劑加工FormulatedHerbicide

經(jīng)過(guò)配制的除草劑FormulatedHerbicide經(jīng)過(guò)配制的除草劑LiquidFormulationSCSL,EC

液體制劑－水懸浮劑、可溶性液劑、乳油ConcentratedFlowable具流動(dòng)性的濃縮產(chǎn)品Ondilution稀釋過(guò)程(SC:suspensionconcentrate;SL:solubleconcentrate;EC:Emulsifiableconcentrate

LiquidFormulationSCSL,EC

液SolidFormulationsWPWG固體制劑－可濕粉、水分散粒劑WP:WettablePowder可濕性粉劑WG水分散粒劑

WG(Pepite)WPWG:WaterDispersibleGranule水分散粒劑

可濕性粉劑SolidFormulationsWPWG固體制劑RequirementsofaFormulation制劑產(chǎn)品的要求Basicrequirements基本要求Easy&safetohandle操作簡(jiǎn)單和安全Canbeapplied(sprayed,etc)方便使用（如噴灑等）Worksbiologically具有生物活性Stable(physicallyandchemically)穩(wěn)定性（物理、化學(xué)穩(wěn)定性）Canbemanufactured(tocost)合適的生產(chǎn)成本Addedvaluefromformulations

配成制劑的增值作用Attractiveandeasytohandle能吸引人并容易操作Improvedsafety提高其安全性Improvedefficacy提高其藥效RequirementsofaFormulationWettablepowder可濕性粉劑applicationinEgyptcirca1980應(yīng)用在埃及大約在1980Wettablepowder可濕性粉劑Agriculturalformulationscanbeverysophisticated

農(nóng)藥制劑具有悠久的歷史triggerrupturesweaklinkforfastreleaseatrightplace/timeTriggeredrelease觸發(fā)釋放Polymerlayers聚合物層Firstgeneration第一代Newsurfaceproperties新表面特性Anionic陰離子Cationic陽(yáng)離子Liquid液體+-Improvedhandling改善操作Targetedactivity活性目標(biāo)Differentiatedproducts

產(chǎn)品多樣化Newmarkets

新市場(chǎng)Extended

patentprotection

擴(kuò)大專(zhuān)利保護(hù)范圍ZeonisaReg.trademark觸發(fā)劑割裂脆弱處在合適的時(shí)間/地點(diǎn)釋放AgriculturalformulationscanCropProtectionIndustry:aviewfromtheWest

西方作物保護(hù)工業(yè)概覽Approx$30Billionperannumsales每年銷(xiāo)售額大約300億美元Marketdrivers市場(chǎng)驅(qū)動(dòng)Performanceenhancement增強(qiáng)藥效CostReduction降低成本Environment/regulations環(huán)境/法規(guī)Environmentalconcerns環(huán)境關(guān)注Fewernewactives/newmodesofaction新原藥較少/新作用模式Lifecyclemanagement產(chǎn)品的生命周期管理Howtoenhancevalueofmatureactiveingredients?

怎樣增加成熟原藥的價(jià)值？CropProtectionIndustry:aviWhatdoCompaniesthink?公司在考慮什么？

“Productinnovationusingexistingactiveingredients”

“運(yùn)用新技術(shù)對(duì)現(xiàn)有的原藥進(jìn)行創(chuàng)新”

Combiningactiveingredientsinnovelcombinationproductsdrivesinnovation.運(yùn)用新技術(shù)，對(duì)產(chǎn)品重新配制，以推動(dòng)創(chuàng)新。Novelformulationtechnologyenablesnewproductsfromexistingcompoundswhichhavenewlevelsofactivity,safetyandspectrum,bothassprayedproductsandincreasinglyasseedtreatments.

利用新的制劑技術(shù)可以使現(xiàn)有的原藥，無(wú)論是用于噴灑還是日益增長(zhǎng)的種子處理劑，成為高效、安全、廣譜的新產(chǎn)品。Bayerannualreview:拜爾年度回顧Formulationknow-howtranslatesintocompetitiveedge制劑技術(shù)成為競(jìng)爭(zhēng)的優(yōu)勢(shì)Differenttechnologiesareusedtoformulatetheactiveingredientintoaproductwithoptimalapplicationproperties采用的不同技術(shù)，將原藥配制成具有最佳應(yīng)用性能的產(chǎn)品SyngentaAnnualReview2005先正達(dá)2005年度回顧WhatdoCompaniesthink?公司在考慮FormulationTrends制劑的發(fā)展趨勢(shì)

Increasingcomplexity日益復(fù)雜mixtures,AIproperties,noveltechnology,混合制劑，原藥的性能，新型技術(shù)Continuedregulatorypressure(environment)

持續(xù)的法規(guī)壓力（環(huán)境）costpressures成本壓力Formulationdifferentiationincreasinglyimportanttoagribusiness制劑的多樣性對(duì)農(nóng)業(yè)行業(yè)日益重要FormulationTrends制劑的發(fā)展趨勢(shì)IncFormulationResearch:HistoricView

制劑技術(shù)研究：歷史回顧1970’s2000’s1990’s1980’sEC’sandWPs乳油和可濕性粉劑SC’sandEW’s水懸浮劑&乳液o/wMicrocapsules微膠囊WGs水分散顆粒Adjuvants助劑NovelPhysicalForms具有新性能的產(chǎn)品OilDispersions油分散產(chǎn)品Safety安全Safety,EnvironmentalandEfficacy安全，環(huán)境和有效Convenience/Safety/Environmental方便/安全/環(huán)境Efficacy有效Convenience方便Convenience/labileAIs方便/有效成份進(jìn)入植物組織FormulationResearch:HistoriFormulationBenefits配制成制劑的益處Casestudies:

實(shí)例研究Increasedbiologicalperformance(adjuvants)增強(qiáng)生物性能（助劑）Improvedhandlingandapplicationcharacteristics

改善操作和應(yīng)用特性Controlledrelease&enhancedsafety

控制釋放和增強(qiáng)安全性FormulationBenefits配制成制劑的益處CIncreasedbiologicalperformance

增強(qiáng)生物活性Theuseofadjuvantsmayimprovetheperformanceorallowareducedrateofmanyactiveingredients

助劑的使用可以改善應(yīng)用性能或可以降低使用原藥的用量IncreasedbiologicalperformanAdjuvants:ImprovedEfficacy助劑：改善功效Example:Adjuvantcanimproveactivityby:increasingdropletspreadincreasingleafuptake例如：助劑可以通過(guò)下列方式改善活性增加液滴的擴(kuò)散增加植物葉片的吸收Noadjuvant

沒(méi)有助劑Withadjuvant

有助劑Noveladjuvant新型助劑‘Standard’adjuvant標(biāo)準(zhǔn)助劑Noadjuvant無(wú)助劑時(shí)間Adjuvants:ImprovedEfficacy助Adjuvancy:the“on-off“switchforpinoxaden

當(dāng)天應(yīng)用未處理沒(méi)有助劑有助劑未處理沒(méi)有助劑有助劑應(yīng)用20天以后Adjuvancy:the“on-off“switchNotJustHerbicides!不只是除草劑

BayerWOO2098230-fattyalcoholalkoxylateswithinsecticides

拜爾WOO2098230－烷氧基脂肪醇與殺蟲(chóng)劑

WO2003/099012A1Syngenta先正達(dá)2003/09912A1

Useofphosphonateadjuvantswithinsecticides在殺蟲(chóng)劑中使用磷酸酯做助劑Exemplifiedbybis(2-ethylhexyl)-2-ethylhexylphosphonate(BEEP)例如：雙（2－乙基己基）－2－乙基己基磷酸酯％吸收/轉(zhuǎn)移24小時(shí)后吸收/轉(zhuǎn)移48小時(shí)后吸收/轉(zhuǎn)移死亡率％多殺菌素氯芬新

甲氨基阿維菌素苯甲酸鹽死亡率％死亡率％吸收/imidacloprid的轉(zhuǎn)移NotJustHerbicides!不只是除草劑BaImprovedHandlingandApplication

改善操作和應(yīng)用FormulaM,anewtechnologyinSeedTreatment配方M，在種子處理中的新技術(shù)ImprovedHandlingandApplicatTreatedseeds種子處理CelestExtra(current)CelestExtra（目前）CelestExtraFormulaMCelestExtra配方MFormulaMprovides配方M可以具有Improvedcoverage(homogeneityoftreatment)改善覆蓋層（處理均勻性）Improvedappearance(strongercolour)改善外觀（較強(qiáng)的色澤）

Reducedhumanexposure(lessdust-off)減少與人體接觸（較少脫落）Fasterprocessingoftreatedseed(fasterdrying)加快種子處理過(guò)程（快速干燥）Treatedseeds種子處理CelestExtraLessDust-off:saferproduct

更少的脫落：更安全的產(chǎn)品Dust-offfilter,A8533F@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/03粉塵濾膜，A8533F@200ml/100kg，用于小麥。用400ml水稀釋ST22TA828/03Dust-offfilter,A8533G@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/09

濾膜A8533G@200mL/100kg，用于小麥。用400ml水稀釋ST22TA828/09CelestExtra(current)目前CelestExtraFormulaM配方M脫落，克/100公斤小麥LessDust-off:saferproductHigherproductivityfortreatingcompanies

種子處理公司有更高的生產(chǎn)能力Celest025FS(current)目前Celest025FSformulaM配方MImprovementofbaggingtimeby15%!減少15％的包裝時(shí)間HigherproductivityfortreatiControlledReleaseandEnhancedSafety控制釋放和增強(qiáng)安全性KarateandDemand:microencapsulationprovidesmanybenefits功夫和大滅：微膠囊化可以提供很多好處ControlledReleaseandEnhanceMicroencapsulation

(1stGeneration)微膠囊化（第一代）polymericWall聚合物壁Water水Lambda

in

solvent高效氯氟氰菊脂在溶劑中UVprotectant

紫外線保護(hù)劑DemandHighloadcapacity;safening;environmental高容量；安全；環(huán)保Robust-designedforslowrelease

可靠-設(shè)計(jì)為緩慢釋放Microencapsulation(1stGeneraMicro-encapsulation(2ndGeneration)微乳膠囊化（第二代）氯氟氰菊酯微膠囊劑

Improvedsafety改善安全性Safermammaliantox對(duì)哺乳動(dòng)物更安全Lowersolventlevels更低的溶劑量Improvedperformance改善性能Efficacy>ECbyfastrelease功效>通過(guò)快速釋放的ECUVprotectant防紫外線保護(hù)劑LambdaDemandParathion-methylLambdaZeonMicro-encapsulation(2ndGenerCapsuleSuspensions懸浮劑Capsulessuspendedinaliquidbasegivingaflowablesuspensionconcentrate.

膠囊懸浮在液體中，生產(chǎn)出具有流動(dòng)性的懸浮劑CapsuleSuspensions懸浮劑CapsuMicrocapsules微膠囊Typically1-20micronhollowspheresfilledwithAI通?；钚猿煞直惶钊?～20微米的空心球中Highloadcapacity高容量Aqueous(CS)ordryproducts水溶液（懸浮液）或固體產(chǎn)品Reservoir儲(chǔ)存囊Matrix母體Microcapsules微膠囊Typically1-Controlofparameterstovaryreleaserate:控制參數(shù)以控制釋放速率：particlesize顆粒大小monomercomposition單體成分cross-linkdensity鉸鏈密度wallthickness壁厚Stabiliser穩(wěn)定劑polymeric

wall聚合物墻壁continuousPhase連續(xù)相

ActiveIngredient活性成分r’r”c'c"ConventionalMicrocapsulesReleasebyDiffusionControl

常規(guī)的微膠囊釋放是由控制擴(kuò)散完成的釋放速率表面積擴(kuò)散濃度墻壁厚度滲透性擴(kuò)撒系數(shù)分配系數(shù)ControlofparameterstovaryApplicationsBeyondConventionalTechnology

新技術(shù)的應(yīng)用Reducedmammaliantox降低哺乳動(dòng)物毒性TargetingagainstpestPressure將害蟲(chóng)作為目標(biāo)的壓力seasonlongcontrolfromoneapplication一次施藥可長(zhǎng)期有效Reducedantagonism降低抗性Hours/days/monthsTriggers;觸發(fā)劑pH,light,temp，pH，光線，溫度

Hours/days/monthsAIseenbytarget農(nóng)藥有效成份到達(dá)標(biāo)靶EC浮油Microcap微膠囊Hrs/days/mthsExtendedreleaseforestablishedbenefits延長(zhǎng)有效成份釋放到受藥體researchchallenges!研究挑戰(zhàn)Beneficialinsectprotection保護(hù)益蟲(chóng)ApplicationsBeyondConventionChemicallyTriggeredReleaseStrategy

化學(xué)方法觸發(fā)法customdesignedweaklinksareincorporatedintothewallduringpolymerisation在聚合過(guò)程中將結(jié)合力較弱的物質(zhì)嵌入內(nèi)壁triggerisactivatedatchosenmoment-rupturesweaklink在合適的時(shí)間，觸發(fā)劑被激活，結(jié)合力較弱處斷裂puncturesreducewallthickness(r’-r”)tozero,circumventingthenormaldiffusionprocess

滲透物使壁厚變小(r’-r”)到0，打破常規(guī)的正常的擴(kuò)散過(guò)程triggerrupturesweaklinkallowingfastreleaseweaklinkAIAI觸發(fā)劑可以快速釋放結(jié)合力較弱處裂開(kāi)釋放率結(jié)合力較弱的物質(zhì)ChemicallyTriggeredReleaseSAcidTriggeredCapsules酸觸發(fā)膠囊Non-triggered沒(méi)有被觸發(fā)的Triggered觸發(fā)的AcidTriggeredCapsules酸觸發(fā)膠囊NoFutureVision:FromaWesternperspective

未來(lái)前景：西方展望Furtherrestrictionsintheregulatoryenvironment

環(huán)境法規(guī)更加嚴(yán)格Continuedneedforsafer,moreeffectiveproducts持續(xù)需要更安全，更有效的產(chǎn)品Increasedaccessibilitytousefultriggeredsystemsfortargeteddelivery

利用有用的觸發(fā)機(jī)制，增強(qiáng)（藥物）達(dá)到目標(biāo)受體能力Improvedadjuvantsofferreducedapplicationrates改善助劑以降低施用量Increasedroleofpolymericsystemstodeliverbettercontrolledreleasesystems(includingnanotechnologies)

增加聚合系統(tǒng)的作用，更好地控制釋放系統(tǒng)（包括納米技術(shù)，10-9）Greaterunderstandingofcrystallisationprocesses更好地了解結(jié)晶過(guò)程Changingpesticidechemistrieswillprovidecontinuallychangingchallengestotheformulator不斷變化的農(nóng)藥化學(xué)將會(huì)對(duì)制劑開(kāi)發(fā)人員帶來(lái)持續(xù)的挑戰(zhàn)FutureVision:FromaWesternFormulationResearch:Future制劑研究：未來(lái)1990’s???2010’s2000’sNewEC’sandsolvents新型乳油及溶劑SC’sandEW’s-morerobusttechnology懸浮劑和乳液－更多的完備技術(shù)Controlleddelivery控制傳遞Newdryproductstechnology新型固體制劑技術(shù)Adjuvantsanduptakeunderstanding輔劑和吸收的認(rèn)識(shí)NovelPhysicalForms

改變物理性能新技術(shù)Newdeliverytechnology新型傳遞技術(shù)FormulationResearch:FutureFormulationFailure?

配方會(huì)失??？Riskfactors:風(fēng)險(xiǎn)因素-Developmentwastoofast

發(fā)展太快-Poorrawmaterials

原料貧乏-Nottestedinproperconditions

未在合適的條件進(jìn)行測(cè)試Impactoffailure:

失敗帶來(lái)的影響-Poorhandling(sediment,blockedscreens)

施用困難（沉淀，堵塞）-Cropinjury(toomuchproductapplied)傷害作物（用藥量太大）-Lackofefficacy(notenoughproductapplied)

缺乏藥效（產(chǎn)品的應(yīng)用不充分）-Humanexposure(cleaningupthemess!)人體暴露（處理廢物）-Reducedcropyield(impropertreatment)

降低作物產(chǎn)量（不恰當(dāng)?shù)氖褂茫〧ormulationFailure?配方會(huì)失?。縍isConclusions

結(jié)論Formulationsprovidemanybenefits

制劑可以再來(lái)很多好處Improvedefficacy

改善藥效Improvedapplication

改善應(yīng)用Saferhandling

更安全的操作Improvedenvironmentalprofile

改善環(huán)境Etc.

等等Properformulationdevelopmentcantakeyearsofresearchinthelaboratory

一個(gè)合適的制劑通常需要在實(shí)驗(yàn)室里經(jīng)過(guò)數(shù)年的研究Doitright!Reducetheriskoffailure

正確的方法可以降低失敗的風(fēng)險(xiǎn)Addedbenefits&developmenttimecostsmoney!

增加產(chǎn)品的價(jià)值及花費(fèi)的研發(fā)時(shí)間是需要投資的！Conclusions結(jié)論FormulationsprTHANKYOU!謝謝THANKYOU!AgrochemicalFormulationTrends

農(nóng)藥制劑的發(fā)展趨勢(shì)CCPIAGuilin,Guangxi,China中國(guó)–桂林KeithParker,Ph.D.SyngentaAsiaPacificPte.Ltd.AgrochemicalFormulationTrendWhoisSyngenta

先正達(dá)介紹AgrochemicalFormulationTrends

農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents內(nèi)容WhoisSyngenta

先正達(dá)介紹ContentsOurindustryfamilytree國(guó)際農(nóng)化公司發(fā)展概況CibaSandozICIISKBiosciencesMonsantoDuPontShellCyanamidBASFBayerRhone-PoulencHoechstScheringDowRohm&HaasMerck1992199319941995199619971998199920002001NovartisAHPAventis2002AgrevoZenecaOurindustryfamilytree國(guó)際農(nóng)化公Excellentcomplementaryandleadingproductportfolio

卓越全面、領(lǐng)先的產(chǎn)品線Aleaderincropprotection植保領(lǐng)域的領(lǐng)先者Thirdinhigh-valuecommercialseeds高價(jià)值商業(yè)種子排名第三Firstclassresearchanddevelopmentresources一流的研發(fā)資源

Investmentofaround$800mannually

每年投入約八億美元Strongworldwidepresence

業(yè)務(wù)遍布全球Around21,000employeesinover90countries在90多個(gè)國(guó)家擁有2萬(wàn)1千名雇員RichpipelineofCropProtectionandSeedsproducts

豐富的植保和種子產(chǎn)品產(chǎn)銷(xiāo)渠道Syngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司ExcellentcomplementaryandleSyngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司

milliontonnesofcottonisgrownusingourcropprotectionproducts

全球440萬(wàn)噸棉花種植過(guò)程中使用先正達(dá)植保產(chǎn)品

That’stheequivalentof20billionT-Shirts

這相當(dāng)于200億件T恤的用料4.4Syngenta–aleadingglobalagSyngenta–aleadingglobalagribusiness

先正達(dá)－全球領(lǐng)先的農(nóng)業(yè)科技公司70%

ofScotchWhiskyisproducedbySyngentabarley70%蘇格蘭威士忌是用先正達(dá)大麥制造的Syngenta–aleadingglobalagWhatWeDo

我們從事哪些業(yè)務(wù)CropProtection

作物保護(hù)Seeds

種子

ProfessionalProducts

專(zhuān)業(yè)產(chǎn)品

Bio-technology

生物技術(shù)

WhatWeDo我們從事哪些業(yè)務(wù)CropSeeds

Majorproductbrands主要的產(chǎn)品品牌Herbicides

除草劑Professionalproducts

專(zhuān)業(yè)產(chǎn)品Fungicides

殺菌劑Insecticides

殺蟲(chóng)劑Seeds

種子阿克泰金雷世高阿米西達(dá)銳勝泰草達(dá)克無(wú)蹤功夫千層紅Majorproductbrands主要的產(chǎn)品品牌HeRank

排名2006R&Dspend

2006

研發(fā)投入$m1 Syngenta先正達(dá)

2 Bayer拜爾4 BASF巴斯夫5

DuPont

杜邦3

Monsanto

孟山都6 Dow

陶氏As%ofSales

銷(xiāo)售百分比％11%10%10%14%

11%10%Theleaderinresearchanddevelopment

先正達(dá)，研究與開(kāi)發(fā)的領(lǐng)導(dǎo)者Source:PhillipsMcDougall,SyngentaRank

排名2006R&Dspend

2006研發(fā)投MajorR&Dsites

locatedatthe

heartofscientificcommunitiesOthersitesMarker-assistedandseedbreedingcapabilitiesGlobalfieldstationnetworkGlobalR&Dcapabilities全球研發(fā)機(jī)構(gòu)美國(guó)格林斯博羅GREENSBOROFormulationEnvironmentalScience美國(guó)SBIBiotechnologyR&D英國(guó)集能山JEALOTT’SHILLChemicalDiscoveryWeedControlFormulationBioscienceEnvironmentalScience瑞士巴塞爾/斯坦恩BASEL/STEINFungicides,Insecticides&ProfessionalProducts印度果阿GOAChemistryMajorR&Dsites

locatedatthSyngentainChina先正達(dá)在中國(guó)CropProtection

作物保護(hù)Seeds

種子

ProfessionalProducts

專(zhuān)業(yè)產(chǎn)品R&D

研發(fā)SyngentainChina先正達(dá)在中國(guó)CropSAhistoryofmorethan100years

百多年合作歷史AssociatedinvestmentUS$200m目前總投資達(dá)2億美元

40%ofthetotaldirectforeigninvestmentinCPsection投資額占中國(guó)市場(chǎng)植保領(lǐng)域外商直接投資的40％InvestmentinChina

先正達(dá)在中國(guó)的投資Syngenta(Suzhou)CropProtectionCo.,Ltd.SyngentaSeeds

CompanyLtd.SyngentaNantongCropProtectionCo.,Ltd.Ahistoryofmorethan100yeaEnvironmentProtectionResponsibilityinChina

先正達(dá)在中國(guó)環(huán)保社會(huì)責(zé)任“Top100EnvironmentalFriendlyProjects”byStateEnvironmentalProtectionAdministration“—theonlyoneofitskindincropprotectionindustry“

國(guó)家環(huán)保局授予的“百佳環(huán)保工程”榮譽(yù)稱號(hào)－植保行業(yè)中唯一獲此殊榮

“Top10environmentalfriendlyenterprises”“江蘇省十大環(huán)保企業(yè)”

“High-techenterprises”inJiangsuprovince”“江蘇省高新技術(shù)企業(yè)”

Providetechnicalsupportforindustry/nationalstandardssetup

為行業(yè)標(biāo)準(zhǔn)設(shè)定提供技術(shù)支持

EnvironmentProtectionResponsChina’ssustainableagriculturedevelopmentthroughinnovativeresearchandtechnology

通過(guò)創(chuàng)新性的研究和技術(shù)，中國(guó)農(nóng)業(yè)的可持續(xù)性發(fā)展Improvecropproductivity,qualityandsafetythroughintegratedsolutions

通過(guò)完整的方案，提高和改善作物產(chǎn)量，質(zhì)量和安全性UpgradeChinesefarmer’sincomeandthequalityoflife

提升中國(guó)農(nóng)民的收入和生活質(zhì)量SyngentaChinaisCommittedTo

先正達(dá)中國(guó)忠于..China’ssustainableagriculturWhoisSyngenta

先正達(dá)介紹AgrochemicalFormulationTrends

農(nóng)業(yè)化學(xué)配方的發(fā)展趨勢(shì)Contents內(nèi)容WhoisSyngenta

先正達(dá)介紹ContentsFormulationTechnology制劑技術(shù)AgribusinessinvestsheavilyinFormulationScience

在制劑技術(shù)的上開(kāi)發(fā)上，農(nóng)化企業(yè)投入重金B(yǎng)othforfirstlaunchofnewActiveIngredientsandproductlife-cyclemanagement對(duì)新開(kāi)發(fā)的原藥及老的原藥在制劑技術(shù)上都會(huì)投入重金Why?

為什么？FormulationTechnology制劑技術(shù)AgrWhyFormulation?為什么要制成制劑使用？ActiveIngredientsdon’twork….

原藥本身沒(méi)有藥效…………..Untiltheyaremadeintoformulations

……除非原藥被做成制劑后使用

Ourcustomersbuyformulatedproductsinpacks我們的客戶購(gòu)買(mǎi)的是包裝好的農(nóng)藥制劑產(chǎn)品Solutions溶液Emulsions乳液Suspensions懸浮液Solids固體Capsules膠囊WhyFormulation?為什么要制成制劑使用？AcUntreated沒(méi)有使用過(guò)農(nóng)藥Untreated沒(méi)有使用過(guò)農(nóng)藥Un-FormulatedHerbicide

未經(jīng)制劑加工的除草劑Un-FormulatedHerbicide未經(jīng)制劑加工FormulatedHerbicide

經(jīng)過(guò)配制的除草劑FormulatedHerbicide經(jīng)過(guò)配制的除草劑LiquidFormulationSCSL,EC

液體制劑－水懸浮劑、可溶性液劑、乳油ConcentratedFlowable具流動(dòng)性的濃縮產(chǎn)品Ondilution稀釋過(guò)程(SC:suspensionconcentrate;SL:solubleconcentrate;EC:Emulsifiableconcentrate

LiquidFormulationSCSL,EC

液SolidFormulationsWPWG固體制劑－可濕粉、水分散粒劑WP:WettablePowder可濕性粉劑WG水分散粒劑

WG(Pepite)WPWG:WaterDispersibleGranule水分散粒劑

可濕性粉劑SolidFormulationsWPWG固體制劑RequirementsofaFormulation制劑產(chǎn)品的要求Basicrequirements基本要求Easy&safetohandle操作簡(jiǎn)單和安全Canbeapplied(sprayed,etc)方便使用（如噴灑等）Worksbiologically具有生物活性Stable(physicallyandchemically)穩(wěn)定性（物理、化學(xué)穩(wěn)定性）Canbemanufactured(tocost)合適的生產(chǎn)成本Addedvaluefromformulations

配成制劑的增值作用Attractiveandeasytohandle能吸引人并容易操作Improvedsafety提高其安全性Improvedefficacy提高其藥效RequirementsofaFormulationWettablepowder可濕性粉劑applicationinEgyptcirca1980應(yīng)用在埃及大約在1980Wettablepowder可濕性粉劑Agriculturalformulationscanbeverysophisticated

農(nóng)藥制劑具有悠久的歷史triggerrupturesweaklinkforfastreleaseatrightplace/timeTriggeredrelease觸發(fā)釋放Polymerlayers聚合物層Firstgeneration第一代Newsurfaceproperties新表面特性Anionic陰離子Cationic陽(yáng)離子Liquid液體+-Improvedhandling改善操作Targetedactivity活性目標(biāo)Differentiatedproducts

產(chǎn)品多樣化Newmarkets

新市場(chǎng)Extended

patentprotection

擴(kuò)大專(zhuān)利保護(hù)范圍ZeonisaReg.trademark觸發(fā)劑割裂脆弱處在合適的時(shí)間/地點(diǎn)釋放AgriculturalformulationscanCropProtectionIndustry:aviewfromtheWest

西方作物保護(hù)工業(yè)概覽Approx$30Billionperannumsales每年銷(xiāo)售額大約300億美元Marketdrivers市場(chǎng)驅(qū)動(dòng)Performanceenhancement增強(qiáng)藥效CostReduction降低成本Environment/regulations環(huán)境/法規(guī)Environmentalconcerns環(huán)境關(guān)注Fewernewactives/newmodesofaction新原藥較少/新作用模式Lifecyclemanagement產(chǎn)品的生命周期管理Howtoenhancevalueofmatureactiveingredients?

怎樣增加成熟原藥的價(jià)值？CropProtectionIndustry:aviWhatdoCompaniesthink?公司在考慮什么？

“Productinnovationusingexistingactiveingredients”

“運(yùn)用新技術(shù)對(duì)現(xiàn)有的原藥進(jìn)行創(chuàng)新”

Combiningactiveingredientsinnovelcombinationproductsdrivesinnovation.運(yùn)用新技術(shù)，對(duì)產(chǎn)品重新配制，以推動(dòng)創(chuàng)新。Novelformulationtechnologyenablesnewproductsfromexistingcompoundswhichhavenewlevelsofactivity,safetyandspectrum,bothassprayedproductsandincreasinglyasseedtreatments.

利用新的制劑技術(shù)可以使現(xiàn)有的原藥，無(wú)論是用于噴灑還是日益增長(zhǎng)的種子處理劑，成為高效、安全、廣譜的新產(chǎn)品。Bayerannualreview:拜爾年度回顧Formulationknow-howtranslatesintocompetitiveedge制劑技術(shù)成為競(jìng)爭(zhēng)的優(yōu)勢(shì)Differenttechnologiesareusedtoformulatetheactiveingredientintoaproductwithoptimalapplicationproperties采用的不同技術(shù)，將原藥配制成具有最佳應(yīng)用性能的產(chǎn)品SyngentaAnnualReview2005先正達(dá)2005年度回顧WhatdoCompaniesthink?公司在考慮FormulationTrends制劑的發(fā)展趨勢(shì)

Increasingcomplexity日益復(fù)雜mixtures,AIproperties,noveltechnology,混合制劑，原藥的性能，新型技術(shù)Continuedregulatorypressure(environment)

持續(xù)的法規(guī)壓力（環(huán)境）costpressures成本壓力Formulationdifferentiationincreasinglyimportanttoagribusiness制劑的多樣性對(duì)農(nóng)業(yè)行業(yè)日益重要FormulationTrends制劑的發(fā)展趨勢(shì)IncFormulationResearch:HistoricView

制劑技術(shù)研究：歷史回顧1970’s2000’s1990’s1980’sEC’sandWPs乳油和可濕性粉劑SC’sandEW’s水懸浮劑&乳液o/wMicrocapsules微膠囊WGs水分散顆粒Adjuvants助劑NovelPhysicalForms具有新性能的產(chǎn)品OilDispersions油分散產(chǎn)品Safety安全Safety,EnvironmentalandEfficacy安全，環(huán)境和有效Convenience/Safety/Environmental方便/安全/環(huán)境Efficacy有效Convenience方便Convenience/labileAIs方便/有效成份進(jìn)入植物組織FormulationResearch:HistoriFormulationBenefits配制成制劑的益處Casestudies:

實(shí)例研究Increasedbiologicalperformance(adjuvants)增強(qiáng)生物性能（助劑）Improvedhandlingandapplicationcharacteristics

改善操作和應(yīng)用特性Controlledrelease&enhancedsafety

控制釋放和增強(qiáng)安全性FormulationBenefits配制成制劑的益處CIncreasedbiologicalperformance

增強(qiáng)生物活性Theuseofadjuvantsmayimprovetheperformanceorallowareducedrateofmanyactiveingredients

助劑的使用可以改善應(yīng)用性能或可以降低使用原藥的用量IncreasedbiologicalperformanAdjuvants:ImprovedEfficacy助劑：改善功效Example:Adjuvantcanimproveactivityby:increasingdropletspreadincreasingleafuptake例如：助劑可以通過(guò)下列方式改善活性增加液滴的擴(kuò)散增加植物葉片的吸收Noadjuvant

沒(méi)有助劑Withadjuvant

有助劑Noveladjuvant新型助劑‘Standard’adjuvant標(biāo)準(zhǔn)助劑Noadjuvant無(wú)助劑時(shí)間Adjuvants:ImprovedEfficacy助Adjuvancy:the“on-off“switchforpinoxaden

當(dāng)天應(yīng)用未處理沒(méi)有助劑有助劑未處理沒(méi)有助劑有助劑應(yīng)用20天以后Adjuvancy:the“on-off“switchNotJustHerbicides!不只是除草劑

BayerWOO2098230-fattyalcoholalkoxylateswithinsecticides

拜爾WOO2098230－烷氧基脂肪醇與殺蟲(chóng)劑

WO2003/099012A1Syngenta先正達(dá)2003/09912A1

Useofphosphonateadjuvantswithinsecticides在殺蟲(chóng)劑中使用磷酸酯做助劑Exemplifiedbybis(2-ethylhexyl)-2-ethylhexylphosphonate(BEEP)例如：雙（2－乙基己基）－2－乙基己基磷酸酯％吸收/轉(zhuǎn)移24小時(shí)后吸收/轉(zhuǎn)移48小時(shí)后吸收/轉(zhuǎn)移死亡率％多殺菌素氯芬新

甲氨基阿維菌素苯甲酸鹽死亡率％死亡率％吸收/imidacloprid的轉(zhuǎn)移NotJustHerbicides!不只是除草劑BaImprovedHandlingandApplication

改善操作和應(yīng)用FormulaM,anewtechnologyinSeedTreatment配方M，在種子處理中的新技術(shù)ImprovedHandlingandApplicatTreatedseeds種子處理CelestExtra(current)CelestExtra（目前）CelestExtraFormulaMCelestExtra配方MFormulaMprovides配方M可以具有Improvedcoverage(homogeneityoftreatment)改善覆蓋層（處理均勻性）Improvedappearance(strongercolour)改善外觀（較強(qiáng)的色澤）

Reducedhumanexposure(lessdust-off)減少與人體接觸（較少脫落）Fasterprocessingoftreatedseed(fasterdrying)加快種子處理過(guò)程（快速干燥）Treatedseeds種子處理CelestExtraLessDust-off:saferproduct

更少的脫落：更安全的產(chǎn)品Dust-offfilter,A8533F@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/03粉塵濾膜，A8533F@200ml/100kg，用于小麥。用400ml水稀釋ST22TA828/03Dust-offfilter,A8533G@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/09

濾膜A8533G@200mL/100kg，用于小麥。用400ml水稀釋ST22TA828/09CelestExtra(current)目前CelestExtraFormulaM配方M脫落，克/100公斤小麥LessDust-off:saferproductHigherproductivityfortreatingcompanies

種子處理公司有更高的生產(chǎn)能力Celest025FS(current)目前Celest025FSformulaM配方MImprovementofbaggingtimeby15%!減少15％的包裝時(shí)間HigherproductivityfortreatiControlledReleaseandEnhancedSafety控制釋放和增強(qiáng)安全性KarateandDemand:microencapsulationprovidesmanybenefits功夫和大滅：微膠囊化可以提供很多好處ControlledReleaseandEnhanceMicroencapsulation

(1stGeneration)微膠囊化（第一代）polymericWall聚合物壁Water水Lambda

in

solvent高效氯氟氰菊脂在溶劑中UVprotectant

紫外線保護(hù)劑DemandHighloadcapacity;safening;environmental高容量；安全；環(huán)保Robust-designedforslowrelease

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