O-O-Dimethyl-cannabigerol-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEO,O-Dimethyl-cannabigerolCat.No.:HY-137960CASNo.:29106-16-9分?式:C??H??O?分?量:344.53作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:55mg/mL(159.64mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.9025mL14.5125mL29.0250mL5mM0.5805mL2.9025mL5.8050mL10mM0.2903mL1.4513mL2.9025mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:2.75mg/mL(7.98mM);Suspendedsolution;Needultrasonic2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.75mg/mL(7.98mM);Suspendedsolution;Needultrasonic3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.75mg/mL(7.98mM);ClearsolutionBIOLOGICALACTIVITY?物活性O(shè),O-Dimethyl-cannabigerol?種可從??中提取的天然物質(zhì)。O,O-Dimethyl-cannabigerol對(duì)??葡萄球耐藥株具有抗作?(MIC范為1-2μg/mL)。O,O-Dimethyl-cannabigerol屬于?精神活性物質(zhì)[2][3]。體外研究O,O-Dimethyl-cannabigerol(compound1)inhibitsKBcellsgrowthwithIC50sof44.55μM(MTTassay)and69.4μM(SRBassay)[2].O,O-Dimethyl-cannabigerol(0-100μM;48hours)inducescellcytotoxicinNIH3T3fibroblasts,withCD50sof60.46μM(MTTassay)and82.98μM(SRBassay)[2].O,O-Dimethyl-cannabigerolshowsantitumorefficacyagainstmelanomacellsofamouse'sskinwithanIC50of31.3μM[2].CellCytotoxicityAssay[2]CellLine:NIH3T3fibroblastsConcentration:0,1,25,50,100μMIncubationTime:48hoursResult:InducedcellcytotoxicwithCD50sof60.46μM(MTTassay)and82.98μM(SRBassay)REFERENCES[1].HanDS,etal.Synthesisandcytotoxiceffectsofdeoxy-tomentellin.ArchPharmRes.2000;23(2):121-127.[2].CaprioglioD,etal.O-MethylPhytocannabinoids:Semi-synthesis,AnalysisinCannabisFlowerheads,andBiologicalActivity.PlantaMed.2019;85(11-12):981-986.[3].AppendinoG,etal.AntibacterialcannabinoidsfromCannabissativa:astructure-activitystudy.JNatProd.2008;71(8):1427-1430.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr