Methylnaltrexone-Bromide-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMethylnaltrexoneBromideCat.No.:HY-75766CASNo.:73232-52-7分?式:C??H??BrNO?分?量:436.34作?靶點(diǎn):OpioidReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥31mg/mL(71.05mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.2918mL11.4590mL22.9179mL5mM0.4584mL2.2918mL4.5836mL10mM0.2292mL1.1459mL2.2918mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)Methylnaltrexonebromideisdissolvedinsaline[3].BIOLOGICALACTIVITY?物活性MethylnaltrexoneBromide納曲酮的四元衍?物，具有?服活性和選擇性的(mu-opioid)阿?受體拮抗劑，在胃腸道組織中作為外周作?受體拮抗劑發(fā)揮作?。MethylnaltrexoneBromide穿越?腦屏障的能?有限。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體內(nèi)研究At2.0mg/kgMethylnaltrexoneBromide(morphine-inducedmalealbinoHartleystrainguineapigs;injection),numberofcoughsreturnedtobaselinevalueandnociceptionremainedunaffected[2].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?AdvSci(Weinh).2020May27;7(13):1902402.?SciSignal.2017Jul11;10(487).pii:eaam5345.?Anesthesiology.2016Oct;125(4):765-78.?FrontMolNeurosci.2017Nov9;10:350.?Xenobiotica.2018Aug;48(8):804-808.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ChandrasekaranA,TongZ,LiH,etal.Metabolismofintravenousmethylnaltrexoneinmice,rats,dogs,andhumans.DrugMetabDispos.2010;38(4):606-616.[2].FossJF,OrelindE,GoldbergLI.Effectsofmethylnaltrexoneonmorphine-inducedcoughsuppressioninguineapigs.LifeSci.1996;59(15):PL235-PL238.[3].RauckR,etal.Randomized,Double-BlindTrialofOralMethylnaltrexonefortheTreatmentofOpioid-InducedConstipationinPatientswithChronicNoncancerPain.PainPract.2017Jul;17(6):820-828.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4