Leukadherin-1-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELeukadherin-1Cat.No.:HY-15701CASNo.:344897-95-6分?式:C??H??NO?S?分?量:421.49作?靶點(diǎn):Integrin;ComplementSystem作?通路:Cytoskeleton;Immunology/Inflammation儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:5mg/mL(11.86mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3725mL11.8627mL23.7254mL5mM0.4745mL2.3725mL4.7451mL10mM0.2373mL1.1863mL2.3725mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性L(fǎng)eukadherin-1特異性的?細(xì)胞表整合素CD11b/CD18的激動(dòng)劑。Leukadherin-1可增加CD11b/CD18依賴(lài)性細(xì)胞對(duì)?纖蛋?原的粘附，EC50為4μM。Leukadherin-1增強(qiáng)?細(xì)胞對(duì)配體(如ICAM-1)和?管內(nèi)?的粘附，從?減少?細(xì)胞跨內(nèi)?遷移和流?損傷部位。Leukadherin-1抑制先天性炎癥信號(hào)轉(zhuǎn)導(dǎo)。體外研究Leukadherin-1isaspecificagonistoftheleukocytesurfaceintegrinCD11b/CD18(αMβ2;CR3;Mac-1).1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemELeukadherin‐1pretreatmentreducessecretionofinterferon(IFN)‐γ,tumournecrosisfactor(TNF)andmacrophageinflammatoryprotein(MIP)‐1βbymonokine‐stimulatedNKcells.Leukadherin‐1pretreatmentalso

reducessecretionofIL‐1β,IL‐6andTNFbyToll‐likereceptor(TLR)‐2andTLR‐7/8‐stimulatedmonocytes[3].體內(nèi)研究Leukadherin-1(1mg/kg;i.p.;twicedailyfor14days)isbeneficialinpreventinghyperoxia-inducedneonatallunginjury,anexperimentalmodelofbronchopulmonarydysplasia(BPD)[1].AnimalModel:NewbornSpragueDawleyratpups[1]Dosage:1mg/kgAdministration:I.p.;twicedailyfor14daysResult:Beneficialonpreventingthelunginflammatoryresponse,improvedalveolarizationandvasculardevelopment,andreducedpulmonaryvascularremodelingandPHinahyperoxia-inducedexperimentalmodelofBPD.REFERENCES[1].JagarapuJ,etal.EfficacyofLeukadherin-1inthePreventionofHyperoxia-InducedLungInjuryinNeonatalRats.AmJRespirCellMolBiol.2015;53(6):793-801.[2].MaiguelD,etal.Smallmolecule-mediatedactivationoftheintegrinCD11b/CD18reducesinflammatorydisease.SciSignal.2011;4(189):ra57.[3].RobertsAL,etal.Thecomplementreceptor3(CD11b/CD18)agonistLeukadherin-1suppresseshumaninnateinflammatorysignalling.ClinExpImmunol.2016;185(3):361-371.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearc