Posovolone-Co-134444-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPosovoloneCat.No.:HY-141795CASNo.:256955-84-7Synonyms:Co134444分?式:C??H??N?O?分?量:428.61作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(233.31mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3331mL11.6656mL23.3312mL5mM0.4666mL2.3331mL4.6662mL10mM0.2333mL1.1666mL2.3331mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(5.83mM);ClearsolutionBIOLOGICALACTIVITY?物活性Posovolone(Co134444)?種具有?服活性的有助于睡眠的神經(jīng)活性類醇。Posovolone具有抗驚厥和抗焦慮樣活性以及共濟(jì)失調(diào)作?。體外研究Inmice,Co134444(0.5-10mg/kg,IP,15min;1-60mg/kg,PO;30min)demonstratesefficacyagainstpentylenetetrazol(PTZ)-inducedseizureswithanED50of3.3mg/kgafterIPadministrationand9.8mg/kgorally.Similarly,protectionagainstmaximalelectroshock(MES)isobservedwithanED50of4.8mg/kgIPand20.6mg/kgPO.Inrats,Co134444(10-40mg/kg;PO;30min)protectsagainstPTZ-inducedseizuresandMES-inducedseizureswithanED50of23.6mg/kgand25.3mg/kg,respectively[1].REFERENCES[1].VanoverKE,etal.BehavioralcharacterizationofCo134444(3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnan-20-one),anovelsedative-hypnoticneuroactivesteroid.Psychopharmacology(Berl).2001;155(3):285-291.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37