(完整版)藥劑學(xué)知識(shí)點(diǎn)歸納總結(jié)(精華版)

1

3 4

3

5

2

1

2

4

5

6

1

2

3

5

3

4

2

4

3

4

1C 2

1 2 3

5SLS

W/O

6O/W

Span

1 BET 2

3

1

：B

2 0<300

3

4

5

100-200um 6

7

4

5

0W300 ，0400

4

12

3 SDS4

6

78

3

60C

1 HLB 34,2

3 45

3

HLB1.8-3.8W/0

4 Tween

4 5

7

Pluronic

PH

Myrij

Brij

0/W

0/W

Poloxamer

Poloxamer188

0/W

CMC

HLB

HLB3--6

W/0

HLB8--18

0/W

HLB7--9

HLB13-18

CMC

Krafft

Krafft

20>60>40>80

2 3

CMSNa

MCC

CA

CAP

CMC-Na

CC-Na

MC

HPC

L-HPC

HPMC

EC

HPMCP

Tg

60-70C

300

23 3

HPMCAS

1

4

5

2

3

1

2

3

4

2

A

2

B

340C

5

2

3

6

7

PVA

2

3

PVP

5

6

CPVP

EVA

8

9

PEG

2 600

3

PLA

5

1

4

1

5

1

4

7

1

4

4

5

1

TOC\o"1-5"\h\z

1PH2 3

56

12 34

6

1 2 3

1 23

45

6

7

8C

9 10

11 12

ArrheniusVan

tHoff

5mmw10mm

2

3

12

6

4

5

CD：3-CD

1

G-3-CD

2 -B-CD

2

11

1

3

7

4

3

1

4

1

2

1

2

3

4

5

TOC\o"1-5"\h\z

5 54

100400,5 10g/L 6

250C CD

PEG400060002PVP3

Poloxamer188

EC2

EudragitERLRS3

CAPHPMCPCMEC

50mg

1

1 2

4 5

2

3

2

1

2

3

137%

2

3

4

5

3

CMC-NaCAPECMCHPMC

PVA PLAPGA

60%Na2SO4

#

2

#

2 3 4

=[

/

/

*100%

+ ]*100%

1

1

2

30-35%

3

60-85%

45

1/4-1/9

15-20%

2

4

100

3-20um

24.5mm

100

1

2

3

30%

1

2

V

1

70-90%

30-40%

2

2

30%

1

#

F Z

30-60

100C

30-60

0.22um0.3umG6

FF0D

90%

10%

logD

1 1 2

1 2

#

4

11

13

121C

PH

10

PH

0.22um0.3um

Poiseuile

15

PEG300-600

PH4

10%

20%

30%

F0

2

1

6

9

12

14

2

2

2

3

1

2

1 2 3

Z

20-25mV

85%g/ml64.7%g/g

12

4

PH

MC

60-70C;

Stoke

1

2

1

21 2

3

F

01

B

0.1-10um <120nm

1 Tween

Span

2

3

O/W

W/O

4

1

MC

CMC-Na

2

1

2

3

4

3

5

4

74%

1

2

3

4

1

50%

2

3

4

1

2

3

4

1

2

3

1

2

345

6

1

2

<10ml3 V5ml4

V0.2ml

PH5.0-7-0

1 2

3

4

5

1

4

PH4-9

1-2ml5

3

2

3 1 2

TOC\o"1-5"\h\z

6 10C

1 1,2

PEG300400

<50%

PH

Tween80 188

MCCMC-Na

EDTACO2

>5ml

1 2

1

100C30min

5ml 10ml

120-140C

2 160-170C2-4

0.22um

2 0.65-0.8um

0.30um

1

2

PH

PH

3

4

5

4h

1

2

1

2

3

1%

PH3.8-4.0

112C30min

121C15min。

4-10C

PH

VC

15min

15um

5%

PH

>90%

0.5-1.5%

150C

10-20C，1

PH

G6

5.0-9.0

50um

<10ml

1 2 3

4

PH 1 2 3

30-50%

MCPVAPEGPVP

4h

100c

0.25%

30min24

12 12

CMC-Na HPC PVP CPVP

CC-Na

HPMC

PVA

CMSNa

HPMCP

MC

EC

PEG

〉

> >

〉

Noyes-Whitney

1 15%--20% 30-35%

75%

2

1 2 <9.0%3

CRH

CRH

CRHAB=CRHA*CRHB Elder

CRH

10

TOC\o"1-5"\h\z

0.1-0.01g 100

0.01-0.001g

1000 0.001g 1000

1 234 5

<0.2% 4

1

CMC-NaHPC10000

2

5%

PEG

12

31

1 2 <9.0%3

2.5mm

1

2

3

4

5

6

7

8

10

11

12

15

16

17

18

21

22

23

24

=71

25 26 27 28

2 9

1 2

3

30

MCC

31

32

33

34

30-70%

HPMC

PVP

10%

10%

10

11

10-70%

12

13

14

15

16

MCCMC-Na

EC

CMS-Na3

CCNa5

PVPP6

L-HPC

CMS-Na300

2%8

80,7

1 PEG2

8-

#

2

3

4

2

-15%