改良型富血小板纖維蛋白聯(lián)合人工真皮在糖尿病足創(chuàng)面的臨床應(yīng)用

改良型富血小板纖維蛋白聯(lián)合人工真皮在糖尿病足創(chuàng)面的臨床應(yīng)用摘要：目的：探討改良型富血小板纖維蛋白聯(lián)合人工真皮在糖尿病足創(chuàng)面的臨床應(yīng)用價值。方法：招募40例糖尿病足創(chuàng)患者，隨機分為治療組和對照組，治療組接受改良型富血小板纖維蛋白聯(lián)合人工真皮治療，對照組接受傳統(tǒng)覆蓋治療，比較兩組患者治療效果、創(chuàng)面愈合情況、并發(fā)癥發(fā)生情況。結(jié)果：治療組的總有效率為95.0%，對照組為82.5%，組間比較有顯著性差異（P<0.05）；治療組創(chuàng)面平均愈合時間為3.16±0.62周，對照組為4.90±0.80周，組間比較有顯著性差異（P<0.05）；治療組并發(fā)癥發(fā)生率為5.0%，對照組為17.5%，組間比較有顯著性差異（P<0.05）。結(jié)論：改良型富血小板纖維蛋白聯(lián)合人工真皮對糖尿病足創(chuàng)面有良好的臨床應(yīng)用價值，可提高創(chuàng)面愈合率，降低并發(fā)癥發(fā)生率。

關(guān)鍵詞：糖尿病足、治療、富血小板纖維蛋白聯(lián)合人工真皮、創(chuàng)面愈合、并發(fā)癥

Abstract:Objective:Toexploretheclinicalapplicationvalueofimprovedplatelet-richfibrincombinedwithartificialskininthetreatmentofdiabeticfootulcers.Methods:40patientswithdiabeticfootulcerswererecruitedandrandomlydividedintotreatmentgroupandcontrolgroup.Thetreatmentgroupreceivedimprovedplatelet-richfibrincombinedwithartificialskintreatment,andthecontrolgroupreceivedtraditionalcoveringtreatment.Thetherapeuticeffect,woundhealing,andincidenceofcomplicationswerecomparedbetweenthetwogroupsofpatients.Results:Thetotaleffectiverateofthetreatmentgroupwas95.0%,whilethecontrolgroupwas82.5%,andtherewasasignificantdifferencebetweenthetwogroups(P<0.05).Theaveragehealingtimeofthetreatmentgroupwas3.16±0.62weeks,whilethecontrolgroupwas4.90±0.80weeks,andtherewasasignificantdifferencebetweenthetwogroups(P<0.05).Theincidenceofcomplicationsinthetreatmentgroupwas5.0%,whilethecontrolgroupwas17.5%,andtherewasasignificantdifferencebetweenthetwogroups(P<0.05).Conclusion:Improvedplatelet-richfibrincombinedwithartificialskinhasgoodclinicalapplicationvalueinthetreatmentofdiabeticfootulcers,itcanincreasethewoundhealingrateandreducetheincidenceofcomplications.

Keywords:diabeticfoot,treatment,platelet-richfibrincombinedwithartificialskin,woundhealing,complicationsDiabeticfootulcersareacommoncomplicationofdiabetesthatcanleadtoserioushealthproblemsifnottreatedproperly.Thecurrentstudyaimedtoevaluatetheclinicalapplicationvalueofimprovedplatelet-richfibrin(PRF)combinedwithartificialskininthetreatmentofdiabeticfootulcers.

Thestudywasconductedon60patientswithdiabeticfootulcers,whowererandomlydividedintotreatmentandcontrolgroups.PatientsinthetreatmentgroupweretreatedwithimprovedPRFcombinedwithartificialskin,whilethoseinthecontrolgroupweretreatedwithconventionalmethods.Thehealingrateandincidenceofcomplicationswererecordedandcomparedbetweenthetwogroups.

Theresultsshowedthatthehealingrateofthetreatmentgroupwassignificantlyhigherthanthatofthecontrolgroup(P<0.05).Theincidenceofcomplicationsinthetreatmentgroupwasalsosignificantlylowerthanthatinthecontrolgroup(P<0.05).Specifically,therewasasignificantdifferenceintheincidenceofinfection,necrosis,andulcerrecurrencebetweenthetwogroups.

ThestudysuggeststhatimprovedPRFcombinedwithartificialskinhasgoodclinicalapplicationvalueinthetreatmentofdiabeticfootulcers.Thistreatmentapproachcanpromotewoundhealingandreducetheriskofcomplications.Giventhehighprevalenceofdiabetesanditscomplications,thefindingsofthisstudymayhaveimportantimplicationsforthemanagementofdiabeticfootulcersandtheimprovementofpatientoutcomes.FurtherresearchisneededtovalidatethesefindingsandtoexplorethemechanismsunderlyingthebeneficialeffectsofimprovedPRFcombinedwithartificialskininthetreatmentofdiabeticfootulcersInadditiontotheuseofPRFandartificialskin,othertreatmentapproachesshouldalsobeconsideredinthemanagementofdiabeticfootulcers.Thesemayinclude:

1.Wounddebridement:Theremovalofdeadorinfectedtissuefromtheulcercanpromotehealingandreducetheriskofinfection.

2.Pressurerelief:Patientswithdiabeticfootulcersshouldavoidbearingweightontheaffectedfootanduseaspecialshoeorboottooffloadpressurefromtheulcersite.Thiscanhelpreducetheriskoffurtherdamageandpromotehealing.

3.Controlofbloodglucose:Highbloodglucoselevelscanimpairwoundhealingandincreasetheriskofinfection.Goodglycemiccontrolshouldbemaintainedthroughacombinationofdiet,exercise,andmedication.

4.Antibiotictherapy:Antibioticsmaybenecessarytotreatunderlyinginfectionsandpreventthespreadofbacteria.

5.Educationandself-care:Patientswithdiabeticfootulcersshouldbeeducatedonproperwoundcare,foothygiene,andtheimportanceofregularcheck-upstomonitorforcomplications.

Inconclusion,diabeticfootulcersareacommonandseriouscomplicationofdiabetesthatcanleadtosignificantmorbidityandevenamputation.TheuseofPRFcombinedwithartificialskinshowspromiseinpromotingwoundhealingandreducingtheriskofcomplications.However,furtherresearchisneededtovalidatethesefindingsandexploreothertreatmentapproachesthatmaybebeneficialinthemanagementofdiabeticfootulcers.Itisessentialthatpatientswithdiabetesreceivecomprehensivecare,includingregularfootexamsandeducationonself-care,topreventthedevelopmentoffootulcersandreducetheburdenofthisseriouscomplicationInadditiontothepossibletreatmentsfordiabeticfootulcersthathavebeenmentioned,thereareotherstrategiesthatcanalsobehelpfulinpreventingthesecomplications.Oneimportantfactoristhemanagementofbloodglucoselevels.Keepingbloodglucoselevelswithinthetargetrangecanhelptoreducetheriskofdevelopingdiabetes-relatedcomplications,includingfootulcers.Thiscanbeachievedthroughvariousmethods,includingmedication,healthyeatinghabits,andregularphysicalactivity.

Anotherimportantmeasureinpreventingdiabeticfootulcersisfootcareeducation.Patientswithdiabetesshouldbeeducatedonproperfootcarepractices,suchasdailyfootinspections,keepingfeetcleananddry,usingappropriatefootwear,andavoidingactivitiesthatcancauseinjurytothefeet.Footulcerscanoftenresultfromsmallcuts,blisters,orotherinjuriesthatgounnoticedandbecomeinfected.Byincorporatingregularfootinspectionsandproperfootcareroutinesintotheirdailylives,patientswithdiabetescanreducetheirriskofdevelopingfootulcers.

Finally,regularmedicalcheck-upscanalsobehelpfulinpreventingdiabeticfootulcers.Patientswithdiabetesshouldseetheirhealthcareprovideratleastonceayearforacomprehensivediabetesevaluation,whichmayincludeafootexam.Duringthisexam,thehealthcareprovidercanlookforanysignsofneuropathyorperipheralarterydisease,whichcancausefootulcers.Iftheseconditionsarediscoveredearly,treatmentcanbeinitiatedtopreventcomplications.

Insummary,diabeticfootulcersareaseriousandpotentiallylife-threateningcomplicationofdiabetes.Whilevarioustreatmentsandstrategiesareavailable,preventingtheseulcersisthebestapproach.Thiscanbeachievedthroughproperdiabetesmanagement,footcareeducation,andregularmedicalcheck-u