神經(jīng)傳導介質(zhì)抑制類勝肽專家講座

神經(jīng)傳導介質(zhì)抑制類勝肽（Neurotransmitter-inhibitingpeptides）acetyl-glutamyl-glutamyl-methyoxylglutaminyl-arginyl-arginylamide(Argireline)在細胞外藉由影響鈣離子調(diào)控胞吐作用（Calcium-dependentexocytosis）所需蛋白質(zhì)生成，進而抑制神經(jīng)介質(zhì)釋放。藉由減少肌肉收縮而減少細紋和皺紋SNAREcomplex是膜上蛋白質(zhì)調(diào)控神經(jīng)胞吐作用關鍵，因為此一複合物會導致（Catecholamine）釋放，假如Catecholamine釋放太多就會導致皺紋以及細紋形成；所以此類勝肽就是抑制SNAREcomplex生成

神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第1頁生長因子GrowthFactorEGF:EpidermalGrowthFactor表皮細胞生長因子刺激老化皮膚細胞再活化刺激表皮細胞生長刺激其它活細胞激素分泌刺激纖維母細胞分泌膠原蛋白及彈力蛋白刺激受傷組織血管增生，加速癒合傷口癒合過程中預防疤痕形成抗皺FGF:FibroblastGrowthFactor纖維母細胞生長因子皮膚再生刺激膠原蛋白及彈力蛋白合成刺激纖維母細胞生長刺激老化組織再生以及傷口癒合刺激表皮細胞生長及移動刺激毛髮生長，預防白頭髮形成刺激玻尿酸合成IGF:InsulinlikeGrowthFactor類胰島素生長因子飾演與生長荷爾蒙相同功效刺激骨骼、肌肉及神經(jīng)再生刺激受傷組織血管增生減緩腦下垂體老化刺激玻尿酸合成刺激毛髮生長並預防落髮VEGF:VascularEndothelialGrowthFactor血管內(nèi)皮細胞生長因子血管內(nèi)皮細胞生長因子是強力新血管生長因子刺激血管細胞增生刺激血管細胞移動TGF-β3:TransformingGrowthFactor-β3多功效細胞激素刺激細胞繁殖、生長及分化去除疤痕形成協(xié)助傷口癒合神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第2頁化粧品奈米科技風潮

奈米結構易滲透至皮膚內(nèi)層，讓化妝品效果再也不侷限在單純表面功夫奈米載體可使其成份滲透至真皮層與角質(zhì)層交界處，對需要深層吸收才得以發(fā)揮美白、防皺與塑身等功效，能夠得到更有效發(fā)揮神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第3頁化粧品與奈米科技奈米化原料粒子NanoparticleTitaniumdioxide、Zincoxide、IronoxideMicaandothermetaloxide奈米容器載體NanocarrierLiposomeandethosomeNanosomeandmicelleFullerene奈米化纖維材料NanofiberMaskcontainingchitin/chitosanfiber神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第4頁Happi

LindsayElkins,ContributingEditor,DecemberAgegracefully?Nottoday’sconsumer,whooftenseeksanti-agingadvicefromherdermatologistwho,moreoftenthaneverthesedays,marketshisorherownlineofproducts.Salesofprofessionalskincareproductsrose13%in,withanti-agingproductsleadingthecategory.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第5頁TheInternationalTop301.UnileverUnitedKingdom$25.48billion2.L’OréalFrance$23.3billion3.HenkelGermany$9.75billion4.KaoJapan$9.6billion5.ReckittBenckiserUnitedKingdom$9.42billion6.BeiersdorfGermany$6.38billion7.ShiseidoJapan$6.35billion8.LVMHFrance$3.74billion9.LionJapan$2.65billion10.ChanelFrance$2.5billion11.YvesRocherFrance$2.41billion12.NaturaBrazil$2.2billion13.GlaxoSmithKlineUnitedKingdom$2.1billion14.AmorePacificKorea$1.78billion15.KoséJapan$1.58billion神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第6頁TheInternationalTop3016.ClarinsFrance$1.38billion17.OriflameSweden$1.37billion18.LGKorea$1.26billion19.PuigSpain$1.21billion20.PierreFabreFrance$1.0billion21.YSLBeautéTheNetherlands$889million22.PolaJapan$878million23.PZCussonsUnitedKingdom$828million24.TheBoltonGroupTheNetherlands$739million25.SunstarJapan$637million26.TheColomerGroupSpain$598million27.MandomJapan$556million28.LornameadUnitedKingdom$537million29.MenardJapan$521million30.FanclJapan$430million神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第7頁1.Unilever

MajorProducts:Personalcare—Axe/Lynx,Rexona/SureandDegreedeodorants;Dove,Caress,LuxandLifebuoysoaps;Pond’sandVaselineskincareproducts;Organics,SalonSelectives,SunSilk,SuaveandThermaSilkhaircareproducts;Close-upandSignaloralcareproducts.Household—Ala,All,Omo/PersilandSurflaundrydetergents;ComfortandSnugglefabricsofteners;Sunlightdishdetergent,Domestosbleach,Cifcleaners.NewProducts:VaselineCocoaButterrange,Clearanti-dandruffshampoo,DomestosZeroLimescalebleach.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第8頁2.L’Oréal

MajorProducts:L’OréalParis,Garnier,MaybellineNewYork,SoftSheenCarson.L’OréalProfessionnel,Kérastase,Redken,Matrix,Mizani,PureologyLuxury—Lanc?me,Biotherm,HelenaRubinstein,Kiehl’s,ShuUemura,GiorgioArmani,ParfumsCacharel,RalphLaurenFragrances,PalomaPicasso,ParfumsGuyLaroche,Diesel,Victor&Rolf,Yue-Sai.ActiveCosmetics—Vichy,LaRoche-Posay,Skinceuticals,Sanoflore.L’Oréal’soperationsalsoincludeTheBodyShopandGalderma,and50%stakesinLeClubdesCréateursdeBeautéandLaboratoiresInnéov.NewProducts:L’OréalProfessionnelColorSupreme,L’OréalProfessionnelHommeCover5greyhaircover,

L’OréalParisGlamShine,DermaGenesis/SkinGenesis,Lanc?meRénergieMorpholiftRareline,L’OréalProfessionnelAgeDensiforce,LaRoche-PosaySubstianeanti-agingreplenishingcare,MaybellineDefine-A-Lash,Lanc?meVirtuosemascara,ShuUemuraArtofHair,MizaniButterBlend.

神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第9頁3.Henkel

MajorProducts:LaundryandhomecaresoldunderbrandssuchasPersil,Purex,Dixan,Vernal,MirColueurs,Pril,Bref,SpeeWei?er,RieseandSomat.CosmeticsandtoiletrybrandsincludeSchwarzkopf,Fa,RightGuard,Dial,Igora,Palette,Gliss,Kur,Schauma,Taft,TheramedandDiadermine.NewProducts:Laundry—PurexNaturalElements,Persil20°Cformulation;Haircare—PaletteGoldenGlossBrowns,GlissKurOilNutritive,SchuamaKiwiGlanz,TaftVolumePower,DreiWetterTaftSensitive,BlondMePersonalcare—FaNaturalsshowergelanddeodorant,DialYogurt;Skincare—DiadermineAgeExcelliumOralcare—Theramed2-in-1freshness,TheramedTitanFresh.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第10頁4.Kao

www.kao.co.jpMajorProducts:?Householdproducts,personalcareproductsandcolorcosmetics.NewProducts:Sofinabeauté,SofinaPrimavistabasemakeup,Asiencehaircare(relaunchedglobally),Megurismsteameyemask,AttackBiogelliquidlaundrydetergent,Men’sBioreline(relaunchedinJapan).

神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第11頁5.ReckittBenckiser

MajorProducts:Surfacecare—CillitBang,Lysol,Dettol,Harpic.Fabriccare—Calgon,Vanish,Resolve,Spray‘nWash,Woolite.Dishwashing—Finish,ElectrasolHomecare–Airwik,MorteinHealthandPersonalcare—Veet,Dettols,Clearasil.NewProducts:CillitBangGrease&Floor,DettolHerbalsoapandshowergel,VeetPumpPack,MorteinwithDettol,MorteinNaturgardrange,AirwickFreshmaticMini.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第12頁6.Beiersdorf

MajorProducts:Skincare,beautycareandtoiletriessoldunderbrandnamesthatincludeNivea,Eucerin,LaPrairie,Slek,Labello,8x4,Florena.NewProducts:NiveaDiamondGlosshairproducts;NiveaMySilhouette

bodyshapinggel;NiveaforMenExtremeComfort;NiveaForMenwhiteningoilcontrol(India);NiveaforMenDNAgeanti-wrinklemoisturizer;NiveaGood-ByeCellulitedietarysupplementcapsules(U.S.only);EucerinHyaluron-Fillereyecare.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第13頁7.Shiseido

www.shiseido.co.jpMajorProducts:Skincare,colorcosmetics,suncare,fragrances,haircareandtoiletries.MajorbrandsincludeShiseido,Carita,Decleor,IPSA,Ettusais,D’icilaParfumsIsseyMiyake,ParfumsJeanPaulGaultier,ParfumsNarcisoRodriguez,Nars,CledePeauBeauteZa,ParfumsSergeLutens,UraraandSupremeAupres.NewProducts:ClédePeauBeautéLaCrèmes,Revital,AquaLabelskincare,Acne&skinlighteningseries,Unomen’sskincare,TsubakiGoldenRepairhaircare,UraraMakeup,ShiseidoBOPintensiveskincollectiveprogram,ShiseidoZenfragrance(relaunch).神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第14頁8.LVMH

MajorProducts:FragrancesandcosmeticsoldunderbrandssuchasChristianDior,Guerlain,Givenchy,Kenzo,AcquadiParma,ParfumsLoewe,Benefit,FreshandMakeupForever.LVMHalsoownsSephora,thebeautyproductsretailer.NewProducts:Dior—Fahrenheit32formen,MidnightPoisonAddictShinefragrances,CaptureL’OredeVie,Diorskinfoundation,Backstage.Guerlain—L’InstantMagic,EaudeShalimar,AquaAllegoriaFigueIrisandAquaAllegoria

LaurierRéglisse,

CruelGardénia,CherryBlossomdelight,MyInsolence.ParfumsGivenchy—OrganzaJasmin,VeryIrresistibleRosaDamascena,AmarigeMimosa,Vetyver,RougeInterditlipstick.ParfumsKenzo—TokyobyKenzoformen,VintageEdition.Benefit—LoveYourLook,ThatGalfacebrighteningprimer.MakeupForever—AquaEyeswaterproofeyeliners.AcquadeParma—ColoniaIntensa.ParfumsLoewe—Quizas,QuizasQuizas.FendiPalazzoandPucciVivarafragrances.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第15頁9.Lion

www.lion.co.jpMajorProducts:Oralcare(toothpastes,toothbrushesmouthwashes,breathfresheners,dentalneeds);beautycare(shampoos,conditioners,treatments,hairstylingproducts,men’shaircare,soap,bodywashes,skincare,antiperspirantsanddeodorants);fabriccare(laundrydetergentsandadditives,bleaches,fabricsofteners);homecare(dishwashingdetergents,disinfectants,householdcleaners,kitchen-relatedproducts)andinsecticides.NewProducts:Household—SoflanwithFragranceandDeodorantfabricsoftener,TopKaoriTsuzukuchamomile-scentedliquidlaundrydetergentwithfabricsoftener,LookO2Cleaner(jointproductwithHenkel),Charmygel-baseddishwashercleaner/detergent.Oralcare—DentorSystemaEXExtraHerb,Medishoralcaregum.Personalcare—BanDeodorantMist,BanRefreshPowderSheets,Bathologyskincare,ProTecHeadmen’shaircare.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第16頁10.Chanel

MajorProducts:Skincare,colorcosmeticsandfinefragrances.NewProducts:Skincare—SublimageEssentialRegeneratingCream,Hydramax+ActivemoisturetintedlotionSPF15Colorcosmetics—Facettesd’ornailcolor;RobertsonBoulevardlimitededitionnailcollectionFragrance—AllurepourHommeEditionBlanche,

ChanceEauFra?che,AllureHommeSportCologneSport,No.5EauPremière.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第17頁11.YvesRocher

MajorProducts:Skincare,cosmeticsandfinefragrancesmarketedunderthebrandnamesofYvesRocher,DanielJouvance,Dr.PierreRicaudandKiotis.NewProducts:Fragrance—Naturelle,CommeuneévidenceHomme.Personalcare—PlaisirsNatureKiwieaudetoiletteandshowergelSkincare—CultureBio.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第18頁12.Natura

MajorProducts:NaturaEkos,NaturaTododia,NaturaChronos,NaturaMam?eeBebê,NaturaDiversa,NaturaAmorAmérica.NewProducts:NaturaAmorAmérica,NaturaNaturé,NaturaTododia,NaturaDiversaHidrata??oProlongada,NaturaChronosPolitensordeSoja,NaturaAguas,NaturaFixplant,NaturaFaces,NaturaMam?eeBebe,NaturaEkosCacau,NaturaHomemChromo,NaturaErvaDoceHidratanteFacial,NaturaCrerParaVerBolsaAmigadoMeioAmbiente.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第19頁13.GlaxoSmithKline

MajorProducts:Toothpasteandmouthwash—Aquafresh,Dr.Best,Macleans,Odol,OdolMed2,Polident,Polygrip,SensodyneDenturecare—Polident,Polygrip,Corega.NewProducts:Aquafreshiso-activefoaminggel神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第20頁14.AmorePacific

www.amorepacific.co.krMajorProducts:Skincareandmakeup—Laneige,Iope,Mamonde,Innisfree,Hera,Lirikos.Fragrances—Lolita,Lempika,CastelBajac,Espoir.NewProducts:SulwhasoosuEssence,ioPEWhitegenRXC,V=BYeginseng,premiummakeupfromLaneige,HappyBathBlueSpaEssentialBodyCleanser.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第21頁15.Kosé

www.kose.co.jpMajorProducts:Skincare,cosmeticsandtoiletries.NewProducts:Junkisuiskincare.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第22頁16.Clarins

MajorProducts:Skincare,finefragrance,colorcosmeticsandsuncaresoldunderbrandnamessuchasClarins,ThierryMugler,Azzaro,StellaCadenteandMyBlend.NewProducts:MyBlendcustomizableskincare神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第23頁17.Oriflame

MajorProducts:Skincare,fragrances,colorcosmetics,toiletriesandaccessories.NewProducts:EnigmaandRadiantLightsfragrances,OptimalsRadianceGlowselftanner,LiftExpert,PerfectBody,LashExtreme,RoyalVelvetIntensiveRevitalizingClothMask.Also,DiamondMusk,SilkyKisslipstick,DiamondCellularAnti-agingcreamandDermoprofessionalBio-PeelingKit(allinSeptember).神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第24頁18.LGHousehold&?Healthcare

MajorProducts:Household—laundryanddishwasherdetergent,fabricsoftener,kitchencleaners.Personalcare—toothpaste,shampoo,soap,babycare,skincare,colorcosmeticsandtoiletries.NewProducts:su:m37fermentedcosmetics,BorrowingEarthhouseholdproducts.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第25頁19.Puig

MajorProducts:Fragrances—AdolofoDominguez,AgathaRuízdelaPrada,AgueBrava,Anouk,AntonioBanderas,Barbie,CarmenSevilla,DonAlgodon,Maja,Mango,MassimoDutti,Pachá,Quorom,RoasiroFlores,Sportman,Victori&Lucchino,Zara,BostonMan,1916,AntonioMiro,AzurdePuig,Brummel,Eaud’Ete,Equinox,Farala,Springfield,YachtManBlue,Zinnia.PersonalCare—Payot,Dennenes,HenodePravia,Lactovit,Vitese,

Kinesia,Maja,AguaLavandaPuig,Maderas,Misslyn,Nelia,VF.NewProducts:BlueSeductionforWomen神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第26頁20.PierreFabre

MajorProducts:SkincareandhaircareproductssoldundertheAvéne,Ducray,PierreFabricDermatologie,Klorane,GalénicandRéneFurtererbanners.Comments:PierreFabre’sDermo-Cosmeticsunitearmarks5%ofitssalesforresearchprojects,whichareconductedatitscentersinVigoulet-AuzilandSaint-JacquesHospitalinToulouse.ResearchconductedinToulouseismadepossiblethroughan

agreementbetweenthePierreFabregroup,thelocaluniversityhospitalandToulouseUniversity.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第27頁21.YSLBeauté

MajorBrands:Fragrances,cosmeticsandskincareproducts.BrandsincludeYvesSaintLaurent,Roger&Gallet,StellaMcCartney,AlexanderMcQueen,BoucheronandErmenegildoZegna.

NewProductsFragrance—YvesSaintLaurentElle,ParisNuitdeFete,ParisPontdesAmours,OpiumPoesiedeChineEauxd’Orient,L’HommeYvesSaintLaurentEaud’été,ElleYvesSaintLaurentsummerfragrance,CinémaScénariod’été,BabyDollMagic;ErmenegildoZegnaZZegnaFresh;StellaMcCartneyStellaSheer.Cosmetics—LipTwins.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第28頁22.Pola

www.pola.co.jpMajorProducts:

SkinCare—Alvita,Whitissimo,Day+DayVitax,Botanex,1/f,Plenna,Polissima,BA,SignsSolution28Carats,SignsSolutionWrinkleShot,EvangileCosmetics—Whitissimo,Silfique,Vivoke,Aniak,Maquifard,SuperSuncare,SouthernCallBodyCare—Feel&Heal;HairCare—IdeaStyle,SimfreeHairColorMen’sCare—Galantom,GRShotS.NewProducts:Whitissimobasemakeup.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第29頁23.PZCussons

MajorProducts:PersonalcareproductssoldunderbrandsincludingImperialLeather,Joy,CussonsKids,Premier,Carex,Baby,Luksja,Makler,SweetSeventeen,VenusHair,OriginalSource.HouseholdproductbrandsincludingMorningFresh,Elephant,E,Radiant,Robb,DuckandMinerva.NewProducts:ImperialLeatherSkinBliss.神經(jīng)傳導介質(zhì)抑制類勝肽專家講座第30頁24.TheBoltonGroup

MajorProducts:Laundrycareproducts—OminoBianco,Merito,NibroBathroom/kitchencareandcleaners—WCNet,

Fornet,Last,

Dubro,SolivaisselleSurface&FloorCare—Carolin,SMAC,Overlay,

Vetril,WCEendHouseholdsoapproducts—Cyclon,D’orn.PersonalCare—NeutroRoberts,Borotalco,RogéCavaillès,Sanogyl,Somatoline,

RobertsFragrance,AcqueAlleRoseRobert,Citrosil,Botot,Wetties,Soapy,SilxBeauty—Collistarskincare,makeup,haircare.NewProducts:Collistar—LongLastingColorLineandNourishmentandLustreLinesforhaircare,BodyEnergizingTreatmentformen,GlobalAnti-AgeProtectionTanningFaceCreamSPF30-50+,SupertanningMoisturizingDryOilSPF15,SunEffectMake-Upline,TopglossStickReflex,MagnificaPatch-Lifting-DermalFillingRepairingFaceandNeckMask,PerfectaActiveNeckandDécolletéCream,MagicDropsself-tanningconcentrate,BrighteningTouchhighlightingconcealer,EyeContourLiftingTreatmentformen,PerfectAdherenceShavingFoam,MoisturizingSoothingSensitiveSkins,PerfectAdherenceShavingFoam,MoisturizingSofteningToughBeards,ExtremeSupermascara,Anti-Time360°forMen.RogéCavaillès—DermatologicalDeo-