教程講稿文件

Moleculesofcellularinteraction(P68)PingMoleculesofcellularinteraction(P68)Ping1ImmunemoleculesImmunemoleculesinvolvedinsignaltransductionbetweenimmunecells???CK:messenger???CK:messengerCAM:providecellcontactCD:surfacemolecule3Cytokine4Cytokine4ConceptofLow-molecular-weightConceptofLow-molecular-weightregulatoryproteinsorglycoproteinssecretedbywhitebloodcellsandvariouscells(vascularendothelialcells,epidemiccellsandfibroblasts)inbody,inresponsetoanumberofstimuli.5InducingOverviewoftheinductionandfunctionofcytokineInducingOverviewoftheinductionandfunctionofcytokineGeneralPropertiesofLow-molecular-GeneralPropertiesofLow-molecular-Producedinresponsetostimulus(Ag,TransientAction:autocrine,paracrineandBindtohighaffinitycellsurfaceNetwork7IndividualCKsareIndividualCKsareproducedbymultiplecelltypes.OnekindofcellscansecretedifferentCKs.8CKactionmayCKactionmaybelocalandMostCKsactclosetowheretheyare9Classificationof——basedonthestructureand1.Classificationof——erleukinsILs（白細(xì)胞介素2.IFN（干擾素3.5.6.SecretedbySecretedbysomeleukocytesandactuponotherleukocytes.ILs1–35IL-2:producedbyIL-2:producedbyCD4Tcells;TcellgrowthInterferonFunction:anti-virus,anti-tumor,immuneThreeInterferonFunction:anti-virus,anti-tumor,immuneThreetypesofTypeIIFN:antiviral13IFN-aandIFN-b,IFN-ω,IFN-εorIFN-TypeIIimmuneIFN-γ,expressedinNKandactivateTypeIIIIL28A/BandIL-coproducedwithIFN-RegulatoryeffectsofRegulatoryeffectsofIFN-TumornecrosisfactorTumornecrosisfactorTNF-αisproducedbyactivatedmononuclearTNF-β:lymphotoxin(LT，淋巴毒素):producedbyactivatedTcellsThebiologicalactivityThebiologicalactivityofTNF-KillorsuppresstumorAgainstinfection(virus,parasites,bacteriaEnhancethephagocyticactivityofEndogenouspyrogen熱原質(zhì)ColonyStimulatingFactorFunction:stimulateformationColonyStimulatingFactorFunction:stimulateformationofcellcoloniesInvolvedinsupportingthegrowthanddirectingthedifferentiationofhematopoieticcellsChemotacticLeukocytesareguidedbychemokineconcentrationChemotacticLeukocytesareguidedbychemokineconcentrationgradientstothesiteofinfectionorinflammation(homing).About50differentchemokinesClassifiedintofourfamiliesClassifiedintofourfamiliesbasedonthenumberandlocationofcysteinresiduesCGrowthFunction:GrowthFunction:cellTGF-β:transforminggrowthfactor-EGF:EpidermalgrowthVEGF:vascularendothelialgrowthPDGF:Platelet-derivedgrowthFunctionsofAnti-infectionFunctionsofAnti-infectionandanti-ImmuneControlofcellularproliferationandAppendixII:theprincipal1,Anti-1,Anti-2,Playroles2,PlayrolesintheinnateimmunesystemTNF-typeIIFN-γ,IL-1,IL-10,IL-12,andPlayrolesintheadaptiveimmuneIL-2,IL-4,IL-5,TGF-β,IL-10andIFN-3,Controlof3,Controlofcellularproliferation4,Stimulationof4,StimulationofGM-CSFpromotesthedifferentiationofbonemarrowprogenitorsM-CSFpromotesgrowthanddifferentiationofprogenitorsintomonocytesandmacrophagesG-CSFpromotesproductionofCKsandCKsand5,Mediate5,MediateTNF-FasL(activatedT)-Fas(targetSurfaceCDSurfaceCD(P71-Clusterof分化抗CellAdhesion細(xì)胞黏附分CellAdhesionCellAdhesionMoleculesMediatecontactMediatecontactandbindingbetweencellsorbetweencellsandextracellularmatrixPlayrolesintheformofreceptor-ligandParticipatingincellrecognition,activationandsignaltransduction,aswellascellgrowth,differentiationandcellmovingAccordingtheirAccordingtheirstructures,CAMsaredividedinto：intergrinselectinIgmucin-likemoleculecadherinIntegrin整合素MediatecontactandIntegrin整合素MediatecontactandbindingbetweenandextracellularStrengthencontactbetweenleukocytesotherParticipateincellactivationproliferationdifferentiation,aswellascausingHeterodimer:αHeterodimer:α+β14kindsofα8kindsofβAccordingtoβsubunit,8Selectin選擇素Selectin選擇素LimitedintheirtissueIdentifyparticularFacilitatetheinteractionsofparticularcell Functioninleukocyteadhesiontoendothelium,inflammationandlymphocyteCRDRecognizeCRDRecognizesomeoligosaccharyls寡糖FunctionsofParticipatingFunctionsofParticipatinginimmunecellsrecognitionandactivationascoreceptorsandcostimulationplayrolesinleukocyteadhesionto2,Leukocyte2,LeukocyteadhesiontoLeukocyterollingLeukocyterollingandVideo:Video:CD(clusterofCD(clusterofAdenominationAparticularmembranemoleculesthatarerecognizedbydifferentmonoclonalAbsaregroupedtogetherasaclusterofdifferentiationServeasindicatorsofthefunctionalleukocytesandothercellsCD1-14capacitiesCDTCDTcellrecognitionandCD2,CD28,CD152(CTLA-BcellrecognitionandIgFcCD2：SRBCR;bindingCD2：SRBCR;bindingLFA-3;adhesionandCD3：transferactiveCD4：receptorofHIV;bindingMHC-I;adhesionandsignaltranductionCD8：bindingMHC