Decursin-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDecursin(Standard)Cat.No.:HY-18981RCASNo.:5928-25-6分?式:C??H??O?分?量:328.36作?靶點(diǎn):PKC;Apoptosis;CXCR作?通路:Epigenetics;TGF-beta/Smad;Apoptosis;GPCR/GProtein;Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Decursin(Standard)Decursin的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Decursin((+)-Decursin)?種有效的抗腫瘤劑。Decursin還?種細(xì)胞毒劑和有效的蛋?激酶C(proteinkinaseC)激活劑。Decursin誘導(dǎo)細(xì)胞凋亡(apoptosis)和細(xì)胞周期停滯在G1期。Decursin在48?時(shí)降低CDK2、CDK4、CDK6、cyclinD1蛋?的表達(dá)。Decursin抑制細(xì)胞增殖和遷移。Decursin具有抗腫瘤、抗炎和鎮(zhèn)痛活性[1][2][3][4]。REFERENCES[1].YimD,etal.Anovelanticanceragent,decursin,inducesG1arrestandapoptosisinhumanprostatecarcinomacells.CancerRes.2005Feb1;65(3):1035-44.[2].JungSY,etal.Decursininhibitsvasculogenesisinearlytumorprogressionbysuppressionofendothelialprogenitorcelldifferentiationandfunction.JCellBiochem.2012May;113(5):1478-87.[3].SonDB,etal.DecursinAlleviatesMechanicalAllodyniainaPaclitaxel-InducedNeuropathicPainMouseModel.Cells.2021Mar4;10(3):547.[4].AhnKS,etal.Decursin:acytotoxicagentandproteinkinaseCactivatorfromtherootofAngelicagigas.PlantaMed.1996Feb;62(1):7-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021