Lansoprazole-Standard-AG-1749-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELansoprazole(Standard)Cat.No.:HY-13662RCASNo.:103577-45-3Synonyms:AG-1749(Standard)分?式:C??H??F?N?O?S分?量:369.36作?靶點(diǎn):Bacterial;ProtonPump;Phospholipase作?通路:Anti-infection;MembraneTransporter/IonChannel;MetabolicEnzyme/Protease儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Lansoprazole(Standard)Lansoprazole的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Lansoprazole(AG1749)質(zhì)?泵抑制劑，能抑制胃酸?成。Lansoprazole(AG1749)中性鞘磷脂酶(N-SMase)的抑制劑(外泌體抑制劑)。體外研究Lansoprazolefrom0.3to3μMinhibitsgastricacidformationinaconcentration-dependentmanner(IC50of0.76μM)[4].Lansoprazole(30-300μM)bothinducedconcentration-dependent,reversibleandreproduciblerelaxationsofarteries[5].體內(nèi)研究Lansoprazole(20-40mg/kg)treatmentsignificantlyattenuatedSTZandHFD-inducedmemorydeficits,biochemicalandhistopathologicalalterations[3].Lansoprazole(20mg/kgand40mg/kg,p.o.)significantlyreducestheSTZandHFD-inducedincreaseinAChEactivity[3].Lansoprazole(20mg/kgand40mg/kg,p.o.)significantlyreducestheSTZandHFD-inducedriseinbrainMPOlevel[3].FurtherHFDmicetreatedwithlansoprazole(20mg/kgand40mg/kg,p.o.)showsamarkeddecreaseinthebodyweightincomparisontothecontrolanimals[3].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?NatCommun.2023Jul14;14(1):4217.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Kokufu,T.,etal.,Effectsoflansoprazoleonpharmacokineticsandmetabolismoftheophylline.EurJClinPharmacol,1995.48(5):p.391-5.[2].RupinderKSodhi,etal.DefensiveeffectoflansoprazoleindementiaofADtypeinmiceexposedtostreptozotocinandcholesterolenricheddiet.PLoSOne.2013Jul31;8(7):e70487.[3].HuaruiZhang,etal.Advancesinthediscoveryofexosomeinhibitorsincancer.JEnzymeInhibMedChem.2020Dec;35(1):1322-1330.[4].JunMatsukawa,etal.AcomparativestudyonthemodesofactionofTAK-438,anovelpotassium-competitiveacidblocker,andlansoprazoleinprimaryculturedrabbitgastricglands.BiochemPharmacol.2011May1;81(9):1145-51.[5].ErdincNaseri,etal.Protonpumpinhibitorsomeprazoleandlansoprazoleinducerelaxationofisolatedhumanarteries.EurJPharmacol.2006Feb15;531(1-3):226-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forrese