Lubeluzole-dihydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELubeluzoledihydrochlorideCat.No.:HY-105084ACASNo.:144665-09-8分?式:C??H??Cl?F?N?O?S分?量:506.44作?靶點(diǎn):SodiumChannel作?通路:MembraneTransporter/IonChannel儲存?式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:2mg/mL(3.95mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.9746mL9.8728mL19.7457mL5mM---------10mM---------請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Lubeluzole(dihydrochloride)?種神經(jīng)保護(hù)劑，能夠阻斷神經(jīng)元電壓門控鈉通道(sodiumchannels)。Lubeluzole(dihydrochloride)還可對?臟鈉通道(sodiumchannels)產(chǎn)?持續(xù)和阻斷作?。Lubeluzole(dihydrochloride)有望?于抗?律失常試劑的研究[1][2]。REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].LeGrandB,etal.Studyoftheinteractionoflubeluzolewithcardiacsodiumchannels.JCardiovascPharmacol.2003Nov;42(5):581-7.[2].LeGrandB,etal.Lubeluzole-inducedprolongationofcardiacactionpotentialinrabbitPurkinjefibres.FundamClinPharmacol.2000Mar-Apr;14(2):159-62.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-