Tamoxifen-Citrate-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemETamoxifenCitrate(Standard)Cat.No.:HY-13757RCASNo.:54965-24-1分子式:C??H??NO?分子量:563.64作用靶點:EstrogenReceptor/ERR;HSP;Autophagy;Apoptosis作用通路:VitaminDRelated/NuclearReceptor;CellCycle/DNADamage;MetabolicEnzyme/Protease;Autophagy;Apoptosis儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Tamoxifen(Citrate)(Standard)是Tamoxifen(Citrate)的分析標準品。本產(chǎn)品用于研究及分析應用。TamoxifenCitrate(ICI46474)是一種口服有效的，選擇性雌激素受體調(diào)節(jié)劑(SERM)，可阻斷乳腺細胞中的雌激素作用，并可激活其他細胞，如骨骼，肝臟和子宮細胞中的雌激素活性。TamoxifenCitrate是一種有效的Hsp90激活劑，可增強Hsp90分子伴侶ATPase的活性。TamoxifenCitrate還可以有效抑制傳染性EBOVZaire和Marburg(MARV)，IC50分別為0.1μM和1.8μM。TamoxifenCitrate可以激活自噬(autophagy)，誘導凋亡(apoptosis)。TamoxifenCitrate還可以誘導CreER(T2)轉(zhuǎn)基因小鼠的基因敲除。REFERENCESOsborneCK.Tamoxifeninthetreatmentofbreastcancer.NEnglJMed.1998Nov26;339(22):1609-18.HawariahA,etal.Invitroresponseofhumanbreastcancercelllinestothegrowth-inhibitoryeffectsofstyrylpyronederivative(SPD)andassessmentofitsantiestrogenicity.AnticancerRes.1998Nov-Dec;18(6A):4383-6.JiaY,etal.Cardiomyocyte-SpecificAblationofMed1SubunitoftheMediatorComplexCausesLethalDilatedCardiomyopathyinMice.PLoSOne.2016Aug22;11(8):e0160755.ZhaoR,etal.TamoxifenenhancestheHsp90molecularchaperoneATPaseactivity.PLoSOne.2010Apr1;5(4):e9934.LauraCooper,etal.ScreeningandReverse-EngineeringofEstrogenReceptorLigandsasPotentPan-FilovirusInhibitors.JMedChem.2020Sep4.FeilS,et,al.InducibleCremice.MethodsMolBiol.2009;530:343-63.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02