最新流行病學(xué)文獻(xiàn)評(píng)價(jià)報(bào)告

1、幻燈片1臨床流行病學(xué)幻燈片2學(xué)生姓名:班級(jí)： 學(xué)號(hào)：本（專）科專業(yè)：臨床醫(yī)學(xué)現(xiàn)攻讀專業(yè)：老年醫(yī)學(xué)導(dǎo)師：幻燈片3幻燈片4評(píng)價(jià)論文題目： Associati on betwee n low-dose folic acid suppleme ntati on and blood lipids concen trati ons in male and female subjects with atherosclerosis risk factors.出處： Med Sci Mon it. 2013; 19: 733刁39.設(shè)計(jì)類型：DRUG CONTROLLED STUDIES藥物對(duì)照研究論文性質(zhì)：預(yù)

2、防幻燈片5幻燈片6The aim of this study was to an alyze the associati on of low-dose folic acidsuppleme ntati on with blood lipids concen trati ons in subjects with atherosclerosis risk factors.Material/MethodsThe study en rolled 124 Caucasian in dividuals (60 M, ages 20-39; and 64 F, ages19 -39) with athero

3、sclerosis risk factors (family history of premature ischemicstroke, arterial hyperte nsion, dyslipidemia, overweight and obesity, cigarettesmok ing, and low level of physical activity). The participa nts were asked to takeFA at a low dose of 0.4 mg/24 h for 12 weeks.ResultsFA levels in creased in fe

4、males (6.3 vs. 12.5 n g/dL; p=0.001) and males (6.4 vs.11.4 n g/dL; p=0.001) and Hcy levels decreased (10.6 vs. 8.3呵ol/L; p=0.001and 11.5 vs. 9.3; p=0.001, respectively). A sig ni fica nt reducti on in meancon ce ntration of total cholesterol in females (203.4 vs. 193.1 mg/dL; p=0.001)and in males (

5、209.5 vs. 201.9; p=0.002) was observed. The low-de nsitylipoprote in cholesterol (LDL-C) levels decreased in females and in males (107.4vs. 99.9 mg/dL; p=0.001 and 121.5 vs. 115.1; p=0.002, respectively). The apoAI concen trati ons in creased in smok ing wome n and in men with BMI>25 kg/m2(p=0.03

6、2 and p=0.024, respectively).Con clusi onsLow-dose FA suppleme ntati on has a ben eficial effect on blood lipids through decreas ing concen trati ons of total cholesterol and LDL-C and in creas ing concen trati ons of apoAI.幻燈片7幻燈片8However, the preve ntive effect of FA on cardiovascular disease rema

7、 ins un clear.Large-scale cli nical trials failed to show a ben efit from Hcy-loweri ng treatme nt in in dividuals with established cardiovascular disease or with history of myocardial in farctio n. However, those studies evaluated high-dose FA suppleme ntatio n as sec on dary preve nti on and were

8、not in vestigati ng low-dose FA suppleme ntati on as primary preve nti on of cardiovascular disease .文章的提出有科學(xué)性，有創(chuàng)新性，可行性，與臨床密切相關(guān) 幻燈片9類型：藥物對(duì)照(自身前后對(duì)照)，臨床試驗(yàn)性研究樣本選擇：In itially, FA suppleme ntati on was offered to 147 subjects, 23 of whom (15.6%) were excluded in the course of the study due to non-complia

9、 nee (irregular tak ing of FA, stopp ing it altogether, or not report ing for the follow-up exam in ati on at the end of the treatme nt period).未做樣本含量估算?；脽羝?0The study was approved by the Bioethics Committee of the Pomera nian Medical Un iversity in Szczeci n, Pola nd and a writte n consent was obta

10、 ined from all participa nts.經(jīng)倫理委員會(huì)同意，患者知情同意，未使用盲法幻燈片11The study en rolled 124 Caucasian in dividuals (60 M, ages 20-39; and 64 F, ages19 -39) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hyperte nsion, dyslipidemia, overweight and obesity, cigarette smok

11、ing, and low level of physical activity).樣本選取合適幻燈片12所用名詞定義明確，診斷指標(biāo)，測(cè)量方法，結(jié)局指標(biāo)清晰，可靠性高幻燈片13共5個(gè)表，結(jié)果清晰，資料詳盡，內(nèi)部符合性高幻燈片14采用統(tǒng)計(jì)方法合理，按男女分層分析，再按不同危險(xiǎn)因素分析，控制和調(diào)整了混雜因素幻燈片15In view of our results, it seems that low-dose FA suppleme ntati on, used asprimary preve ntio n, has a ben eficial effect on blood lipids through decreas ingconcen trati ons of total cholesterol and LDL and in creas ing concen trati ons of apoAI. To determ ine the value of FA in primary cardiovascular disease preve nti