遺傳學(xué)A類(lèi)課程教學(xué)大綱

1、遺傳學(xué)（A類(lèi)）課程教學(xué)大綱Course Outline課程基本信息（Course Information）課程代碼（Course Code）BI310學(xué)時(shí)（Credit Hours）32學(xué)分（Credits）2.0課程名稱(chēng)（Course Name）遺傳學(xué)（A類(lèi)）Genetics課程性質(zhì)(Course Type)培養(yǎng)計(jì)劃課程授課對(duì)象（Target Audience）授課語(yǔ)言(Language of Instruction)中英雙語(yǔ)Chinese and English開(kāi)課院系（School）生命科學(xué)技術(shù)學(xué)院School of Life Sciences and Biotechnology先修課程

2、（Prerequisite）普通生物學(xué)General Biology授課教師（Teacher）喬中東課程網(wǎng)址(Course Webpage)*課程簡(jiǎn)介（Description）本課程將系統(tǒng)介紹經(jīng)典遺傳學(xué)、分子遺傳學(xué)和數(shù)量遺傳學(xué)的知識(shí)。通過(guò)對(duì)遺傳學(xué)的學(xué)習(xí)，使學(xué)生能了解當(dāng)前遺傳學(xué)的概貌、基本原理和遺傳學(xué)方法，及其與生命科學(xué)其他學(xué)科的聯(lián)系，從而使學(xué)生能夠正確理解生命現(xiàn)象的本質(zhì)，并為他們進(jìn)一步在更深入的層次上了解遺傳學(xué)的遺傳機(jī)制打下基礎(chǔ)。通過(guò)對(duì)遺傳學(xué)的學(xué)習(xí)，學(xué)生們應(yīng)該能夠系統(tǒng)地掌握遺傳學(xué)的學(xué)科前沿動(dòng)態(tài)和發(fā)展趨勢(shì)。*課程簡(jiǎn)介（Description）This course will systematic

3、ally introduce knowledges on classical genetics, molecular genetics and quantitative genetics. Through study, students are supposed to have an overview understanding of the principles and methods of genetics. Meanwhile, students should make clear the linkage between genetics and other subjects in li

4、fe science and get a good understanding of the essence of life phenomena. In all, the course laid the foundation for students to get a further understandingof the genetic mechanisms, and students are supposed to grasp the frontier developments and trends in genetics through this study.課程教學(xué)大綱（course

5、syllabus）*學(xué)習(xí)目標(biāo)(Learning Outcomes)1. 了解當(dāng)前遺傳學(xué)的概貌、基本原理和遺傳學(xué)方法，及其與生命科學(xué)其他學(xué)科的聯(lián)系。Have an overview understanding of the principles and methods of genetics, Make clear the linkage between genetics and other subjects in life science.2. 能夠正確理解生命現(xiàn)象的本質(zhì)，并為他們進(jìn)一步在更深入的層次上了解遺傳學(xué)的遺傳機(jī)制打下基礎(chǔ)。Have a good understanding of th

6、e essence of life phenomena,Lay foundations to get a further understandingof genetics.3.系統(tǒng)地掌握遺傳學(xué)的學(xué)科前沿動(dòng)態(tài)和發(fā)展趨勢(shì)。Grasp the frontier developments and trends in genetics.*教學(xué)內(nèi)容、進(jìn)度安排及要求(Class Schedule&Requirements)教學(xué)內(nèi)容學(xué)時(shí)教學(xué)方式作業(yè)及要求基本要求考查方式緒論2課堂講授1. 遺傳學(xué)中的三個(gè)里程碑，2. DNA是遺傳物質(zhì)，3. 遺傳和進(jìn)化，4. 遺傳分析的層次，5. 遺傳學(xué)在人類(lèi)生活中的應(yīng)用。掌握

7、遺傳物質(zhì)的基礎(chǔ)是核酸，掌握中心法則，掌握遺傳分析的方法，熟悉遺傳學(xué)研究中的三個(gè)里程碑，了解遺傳學(xué)在人類(lèi)生活中的應(yīng)用。作業(yè)Introduction2Lecture1: Three Milestones in Genetics, 2: DNA is the genetic material, 3: Genetics and evolution, 4: Stage of genetic analysis, 5: The application of genetics in human lifeGrasp that nucleic acid is genetic material; grasp the

8、 central dogma; master genetic analysis methods; familiar with three milestones; understand the application of genetics in human life.Homework細(xì)胞生殖2課堂講授1.細(xì)胞和染色體，2. 有絲分裂， 3. 減數(shù)分裂。掌握原核細(xì)胞與真核細(xì)胞的區(qū)別，掌握染色體的結(jié)構(gòu)和功能，掌握減數(shù)分裂的結(jié)構(gòu)，掌握聯(lián)會(huì)、交換、解聚等概念；熟悉有絲分裂和減數(shù)分裂的各個(gè)時(shí)相；了解各細(xì)胞器的結(jié)構(gòu)和功能。作業(yè)Cellreproduction2Lecture1: Cell and chro

9、mosome, 2: Mitosis, 3, Meiosis.Grasp the difference between prokaryotes and eukaryotes, master the structure and function of chromosome, grasp the structure of meiosis, master concepts of Federation, exchange and de-polymerization; familiar with the phases in mitosis and meiosis; understand the stru

10、cture and function of organelles.Homework孟德?tīng)柪碚摚哼z傳的基本原則2課堂講授1. 孟德?tīng)栠z傳的研究，2. 孟德?tīng)栐瓌t的應(yīng)用，3. 遺傳假說(shuō)的建立和測(cè)試，4. 孟德?tīng)栐碓谌祟?lèi)遺傳學(xué)中的應(yīng)用掌握孟德?tīng)柪碚摰娜齻€(gè)基本原則，掌握遺傳分析的基本方法，掌握家系圖譜中的各種符號(hào)的含義；熟悉各種遺傳分析方法的應(yīng)用范圍；了解遺傳咨詢(xún)的應(yīng)用范圍。作業(yè)Mendels theory: the basic principles of heredity2Lecture1: Research of Mendelian genetic, 2: Application of Mend

11、elian principles, 3: Build and test of genetic hypothesis, 4: Application of Mendel principles in human geneticsMaster the three basic principles of Mendelian theory, grasp the basic methods of genetic analysis, and grasp the meaning of various pedigree symbols; familiar with the range of applicatio

12、n of various methods of genetic analysis; understand the application of genetic counseling.Homework孟德?tīng)柪碚摰难由?課堂講授1. 等位基因變異和基因功能，2. 從基因型到表型掌握顯性、隱性、不完全顯現(xiàn)、共顯性、復(fù)等位基因、等位基因系列、外顯率和表達(dá)度、上位性等概念，掌握影響基因功能的因素；熟悉基因的交互作用、基因的多效性等，了解突變顯性和隱性的規(guī)律。作業(yè)Extending of Mendels theory4Lecture1: Allelic variation and gene functio

13、n, 2: From genotype to phenotypeGrasp concepts of dominant, recessive, not fully apparent, co-dominant, complex alleles series, penetrance, expression degree and epistasis, grasp factors that influence gene function; familiar gene interactions, understand the laws of dominant and recessive mutations

14、.Homework孟德?tīng)柪碚摰娜旧w基礎(chǔ)4課堂講授1. 染色體，2. 遺傳的染色體理論，3. 人類(lèi)的性連鎖基因，4. 性染色體和性別決定，5. X-連鎖基因的劑量補(bǔ)償。掌握基因與染色體的關(guān)系，掌握減數(shù)分裂時(shí)基因的重組和分離的規(guī)律，掌握性染色體和性別決定的基本理論，掌握性別決定過(guò)程中的X-連鎖基因劑量補(bǔ)償?shù)脑瓌t；熟悉人類(lèi)性染色體連鎖疾病的種類(lèi)和診斷原則；了解相關(guān)模式生物染色體的數(shù)量。作業(yè)Chromosome foundation of Mendels theory4Lecture1: chromosome, 2: Chromosome theory of heredity, 3: Human s

15、ex-linked genes, 4: Sex chromosomes and sex determination, 5: Dosage compensation X- linked genesGrasp the relationship between genes and chromosomes, master the law of recombinati0on and separation in meiotic, master the basic theory of sex chromosomes and sex determination, master the principles o

16、f dosage compensation ofX- linked gene in sex determination; familiar with types and principles of diagnosis of human sex chromosomes disease; understand the chromosome number of relevant model organisms.Homework染色體數(shù)量和結(jié)構(gòu)的變異4課堂講授1. 研究染色體的相關(guān)細(xì)胞學(xué)技術(shù)，2. 多倍性，3. 非整倍體，4. 染色體結(jié)構(gòu)的重排。掌握多倍性、非整倍體等概念，掌握染色體重排的方式以及對(duì)生

17、物表型的影響，熟悉染色體數(shù)量和結(jié)構(gòu)異常造成的疾病，了解研究染色體的相關(guān)細(xì)胞學(xué)技術(shù)。作業(yè)Variation of number and structure of chromosome4Lecture1: Related cytological methods in researchingchromosome, 2: Polyploidy, 3: Aneuploidy, 4: Rearrangement of chromosome structureGrasp the concepts of polyploidy, aneuploidy and others, master the princip

18、les of chromosomal rearrangements and its impact on biological phenotype, familiar with the diseases caused by chromosome number and structural abnormalities, understanding related cytological methods in researching chromosome.Homework真核生物的連鎖、交換和染色體作圖4課堂講授1. 連鎖、重組和交換，2. 染色體作圖，3. 細(xì)胞遺傳性作圖，4. 人類(lèi)連鎖分析， 5

19、. 重組和進(jìn)化。掌握連鎖、重組和交換與染色體圖距的關(guān)系，掌握利用基因連鎖、重組和交換作圖的方法，掌握人類(lèi)基因連鎖分析的方法；熟悉重組與進(jìn)化的關(guān)系。作業(yè)law of linkage and crossing-over in Eukaryotes and chromosomal mapping4Lecture1: Linkage, restructuring and exchange, 2: Chromosome mapping, 3: Cell genetic mapping, 4: Human Linkage Analysis, 5: Restructuring and evolutionMa

20、ster relationship between linkage, restructuring, exchange and chromosome map distance, master the use of genetic linkage, recombination, and method of exchanging mapping, grasp the human genome linkage analysis methods; familiar with the relationship between restructuring and evolution.Homework微生物遺

21、傳學(xué)4課堂講授1. 病毒的遺傳學(xué)，2. 細(xì)菌的遺傳學(xué)， 3. 細(xì)菌的遺傳物質(zhì)交換的機(jī)制，4. 細(xì)菌遺傳交換的進(jìn)化特征，5. 酵母的遺傳學(xué)。掌握噬菌體溶厡與溶菌交換的遺傳機(jī)制，掌握轉(zhuǎn)化、接合、轉(zhuǎn)導(dǎo)等概念，掌握利用F因子或性質(zhì)粒進(jìn)行遺傳分析的方法，掌握利用四分子進(jìn)行酵母作圖的方法；熟悉噬菌體和細(xì)菌的分子生物學(xué)特征；了解細(xì)菌的遺傳交換與進(jìn)化的關(guān)系。作業(yè)Microbial Genetics4Lecture1: Virus Genetics, 2: Bacterial genetics, 3: Mechanisms of exchange of genetic material in bacteria,

22、 4: Evolution characteristics of genetic exchange in Bacteria, 5: Yeast genetics Master the genetic mechanisms of lysogenic and lyticexchange in phage, master concepts of transformation, conjugation, transduction, master the use of F factor or plasmid genetic analysis methods, master the use of four

23、 molecules of yeast mapping method; familiar with the molecular biological characteristics of phage and bacteria, understand the relationship between bacterial genetic exchange and evolution.Homework復(fù)雜性狀的遺傳2課堂講授1. 遺傳的復(fù)雜形式，2. 數(shù)量遺傳學(xué)的統(tǒng)計(jì)學(xué)方法，3. 數(shù)量性狀的分析，4. 近親繁殖和共同祖先的分析，5.親緣關(guān)系間的相關(guān)性，6. 人類(lèi)行為性狀的數(shù)量遺傳學(xué)。掌握遺傳因素與環(huán)

24、境因素互作對(duì)表型的影響，掌握數(shù)量性狀的特征；熟悉分析復(fù)雜性狀的統(tǒng)計(jì)學(xué)方法；了解人類(lèi)行為性狀的數(shù)量遺傳學(xué)。作業(yè)Heredity of complex traits2Lecture1 Complex genetic forms, 2statistical methods of quantitative genetics, 3 analysis of quantitative traits, 4 analysis inbreeding and common ancestor, 5 relevance between kinship, 6 quantitative genetics in human

25、behavior traits.Master the effect of genetic and environmental Interactions on phenotype, master quantitative characters; familiar with statistical methods to analyze complex traits; understand quantitative genetics in human behavior traits.Homework群體遺傳學(xué)2課堂講授1. 等位基因頻率理論，2. 自然選擇，3. 隨機(jī)遺傳漂流，4. 遺傳平衡中的群體。掌握等位基因頻率的遺傳學(xué)分析方法，掌握Hardy-Weinberg原理，掌握突變、選擇和漂流對(duì)等位基因頻率的影響；熟悉基因頻率變化對(duì)群體生殖和死亡的影