Probucol-DH-581-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEProbucolCat. No.: HY-B0388CAS No.: 23288-49-5Synonyms: DH-581分式: CHOS分量: 516.84作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (193.48 mM)H2O : 40% PEG300 5%

2、 Tween-80 45% salineSolubility: 2.5 mg/mL (4.84 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (4.84 mM); Suspended solution; Need ultrasonic3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.84 mM);

3、 Clear solutionBIOLOGICAL ACTIVITY物活性 Probucol (DH-581) 能抗脂過(guò)多，能通過(guò)增加LDL的代謝率降低液中的膽醇平。IC50 & Target Probucol (DH-581) is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglycerideor VLDL cholesterol. Probucol (DH-581) inhibited cholesterol efflux up to 80% in J774 macropha

4、gesexpressing ABCA1. Probucol (DH-581) is an effective inhibitor of ABCA1-mediated cholesterol efflux withoutinfluencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to theplasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action ofprobucol 1.REFERENCES1. ProbucolMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa