Cobimetinib-R-enantiomer-GDC-0973-R-enantiomer-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECobimetinib R-enantiomerCat. No.: HY-13079CAS No.: 934660-94-3Synonyms: GDC-0973 R-enantiomer; XL-518 R-enantiomer分式: CHFINO分量: 531.31作靶點: MEK作通路: MAPK/ERK Pathway儲存式: Please store the product under the recommended conditions in

2、the COA.溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (188.21 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.8821 mL 9.4107 mL 18.8214 mL5 mM 0.3764 mL 1.8821 mL 3.7643 mL10 mM 0.1882 mL 0.9411 mL 1.8821 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇

3、適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (5.18 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (5.18 mM); Clear

4、 solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (5.18 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Cobimetinib R-enantiomerCobimetinib 的低活性 R 型對映體。Cobimetinib 種有效的選擇性 MEK 抑制劑。REFERENCES1. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis andtumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>