SB-271046-Hydrochloride-SB-271046A-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESB 271046 HydrochlorideCat. No.: HY-14336ACAS No.: 209481-24-3Synonyms: SB 271046A分式: CHClNOS分量: 488.45作靶點: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mon

2、th溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (102.36 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0473 mL 10.2365 mL 20.4729 mL5 mM 0.4095 mL 2.0473 mL 4.0946 mL10 mM 0.2047 mL 1.0236 mL 2.0473 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?

3、為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.12 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.12 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO

4、90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (5.12 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 SB271046 Hydrochloride服活性的5-HT6受體拮抗劑，pKi為8.9。REFERENCES1. Routledge C, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antag

5、onist. Br J Pharmacol.2000 Aug;130(7):1606-12.2. Bromidge SM, et al. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent,selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem. 1999 Jan 28;42(2):202-5.3. Dawson LA, et al. The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontalcortex and hippocampus. Neuropsychopharmacology. 2001 Nov;25(5):662-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-