Oxantel-pamoate-Oxantel-embonate-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOxantel pamoateCat. No.: HY-B1344CAS No.: 68813-55-8Synonyms: Oxantel embonate分式: CHNO分量: 604.65作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (82.

2、69 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (4.55 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.75 mg/mL (4.55 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (4.

3、55 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Oxantel pamoate種泛使的驅(qū)劑，有效針對(duì)Trichuris muris 和鉤。IC50 & Target Antiparasitic 1體內(nèi)研究 The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostomaceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Ox

4、antel pamoate against T.muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically(combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin usingratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.2

5、7, respectively). A highlysynergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necatoramericanus 1.REFERENCES1. Keiser J, et al. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revivalof an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37