all-trans-4-Oxoretinoic-acid-all-trans-4-Keto-Retinoic-Acid-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEall-trans-4-Oxoretinoic acidCat. No.: HY-107494ACAS No.: 38030-57-8Synonyms: all-trans 4-Keto Retinoic Acid分式: CHO分量: 314.42作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80

2、C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (477.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1805 mL 15.9023 mL 31.8046 mL5 mM 0.6361 mL 3.1805 mL 6.3609 mL10 mM 0.3180 mL 1.5902 mL 3.1805 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配?/p>

3、前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.95 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.95 mM); Clear solution3.

4、 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.95 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 all-trans-4-Oxoretinoic acid，維素A 的活性代謝物，可通過作核維甲酸受體 (RARs) 來誘導(dǎo)基因轉(zhuǎn)錄。IC50 & Target Human Endogenous Metabolite體外研究 all-trans-4-Oxoretinoic acid, an act

5、ive metabolite of vitamin A, induces gene transcription via binding tonuclear retinoic acid receptors (RARs) 1. all-trans-4-Oxoretinoic acid is a biologically active geometricisomer of retinoic acid (RA) 2.REFERENCES1. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence

6、 that CYP26A1 is an important enzyme in theelimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.2. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2cells. Adv Exp Med Biol. 1996;387:121-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400