Brimonidine-tartrate-UK-14304-tartrate-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBrimonidine tartrateCat. No.: HY-B0659ACAS No.: 70359-46-5Synonyms: UK 14304 (tartrate); AGN190342 (tartrate)分式: CHBrNO分量: 442.22作靶點(diǎn): Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn

2、 solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 37 mg/mL (83.67 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2613 mL 11.3066 mL 22.6132 mL5 mM 0.4523 mL 2.2613 mL 4.5226 mL10 mM 0.2261 mL 1.1307 mL 2.2613 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存

3、式和期限。BIOLOGICAL ACTIVITY物活性 Brimonidine tartrate (UK 14304 tartrate)是_alpha_2-adrenergic receptor (_alpha_2-AR)受體激動(dòng)劑。IC50 & Target 2-adrenergic Receptor 1.體外研究3HBrimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. 3HBrimonidine (UK 14304)1/2 Master of Small Molecules 您邊的抑制劑師www.

4、MedChemElabels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies ateach site 1-3.REFERENCES1. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Spe

5、cific 3HUK 14,304 binding in human cortex occurs at multiple high affinity stateswith alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.2. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor

6、subtypes. Eur JPharmacol, 1981. 72(4): p. 413-5.3. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats withunilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40