加拿大奶牛肉牛沙門氏菌

1、沙門氏菌Neonatal SalmonellosisPrepared by: Dr. Terry Hunt病因/發(fā)病機(jī)理 Cause & Pathogenesis都柏林沙門氏菌、豬傷寒沙門氏菌和其他種 Salmonella Dublin, S. typhimurium and others 內(nèi)毒素造成分泌過度、吸收降低、炎癥Endotoxins causing hyper secretion, decreased absorption and inflammation細(xì)胞內(nèi)存活、進(jìn)而全身癥狀，可以發(fā)展為細(xì)菌攜帶者 Live in cells and become systemic and ma

2、y progress to carrier state由糞便和口途徑傳播Transmission is by fecal/oral route 危險(xiǎn)因素Risk Factors注意：這是人畜共患病(公眾健康) This is a Zoonotic Disease (Public Health)臨床癥狀Clinical Findings通常為產(chǎn)后1-2月Calves are usually 1-2 months of age發(fā)熱Fever頑固性腹瀉-帶血或纖維粘膜Intractable diarrhea may be blood and/or fibrin脫水Dehydration虛弱Weakn

3、ess敗血癥Terminal septicemia 高死亡率High mortality瘦弱Emaciation 尸解和診斷 Post Mortem & Diagnosis大小腸的Pseudodiptheretic membrane in both small and large intestine 腸系膜淋巴結(jié)分離細(xì)菌Isolate organism from mesenteric lymph nodes鑒別診斷Differential Diagnosis腸桿菌病Colibacillosis輪狀病毒Rotavirus冠狀病毒Corona virus產(chǎn)氣莢膜梭菌Clostridium perf

4、ringens球蟲病Coccidiosis隱孢子蟲病后遺癥 Sequelae敗血癥和死亡Septicemia and death 細(xì)菌攜帶者Carrier state 治療Treatment糾正脫水和酸中毒Dehydration - 皮膚皺折和眼球凹陷來確定體重%脫水比例 = 補(bǔ)充的液體量(L) Body weight * % dehydration = litres of fluids required Acidosis - 依據(jù)敏感性/警覺性確定 補(bǔ)充等滲溶液 Add to isotonic solutions 碳酸氫鈉 13gm/L 13 gm of Na bicarbonate in a litre of fluid (1.3%)不能吸吮者Depressed calves that do not suckle靜注液體加碳酸鹽細(xì)心護(hù)理病牛 Nursing calves & mildly affected calves多次口服電解液若喂牛奶，用非碳酸鹽類電解液 抗菌藥 Antimicrobials 僅對(duì)細(xì)菌性腹瀉有效全身使用光譜抗生素連續(xù)口服抗生素時(shí)間僅為3天預(yù)防Prevention & Control出生后2