SR0987 - RORγt Agonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESR0987Cat. No.: HY-101454CAS No.: 303126-97-8分式: CHClFNO分量: 397.7作靶點: ROR作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 150 mg/mL (377.17 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5145 mL 12.5723 mL 25.1446 mL5 mM 0.5029 mL 2.5145 mL 5.0289 mL10 mM 0.2514 mL 1.2572 mL 2.5145 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清

3、的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.29 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.29 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small M

4、olecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.29 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 SR0987RORt 的個激動劑，其 EC50 值為800 nM。IC50 & Target EC50: 800 nM (RORt) 1.體外研究 SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of800nM. SR0987 treatment resu

5、lts in a statistically significant reduction of the surface expression of PD-1whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trendtowards increased IL17 production 1.REFERENCES1. Chang MR, et al. Synthetic RORt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0