Clavulanate-lithium-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEClavulanate lithiumCat. No.: HY-A0256BCAS No.: 61177-44-4分式: CHLiNO分量: 205.09作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealedstorage, away from mois

2、ture)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 50 mg/mL (243.80 mM; Need ultrasonic)DMSO : 5 mg/mL (24.38 mM; ultrasonic and warming and heat to 80C)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.8759 mL 24.3795 mL 48.7591 mL5 mM 0.9752 mL 4.8759 mL 9.7518 mL10 mM 0.4876 mL 2.4380 mL 4.8759 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)

3、備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Clavulanate lithium種效的 -lactamase 抑制劑，可作為抗素 1 2。IC50 & Target -lactamase 1體外研究Clavulanate lithium has weak antibacterial activity against most organisms when administered alone, butgiven in combination with beta-lactam antibiotics prevents antibiotic inactiva

4、tion by microbial lactamase 1.Clavulanate lithium (0.25, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE(1 mg/L) is only marginally more effective than 0.5 mg/L 2.Cell Viability Assay 2Cell Line: L. pneumophila NCTC

5、 1119Concentration: 0.25 mg/L, 0.5 mg/L, 1 mg/LIncubation Time: 0-35 hoursResult: Caused a relatively slow inhibition of growth.REFERENCES1. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob AgentsChemother. 1977 May; 11(5): 852857.

6、2. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies.J Antimicrob Chemother. 1989 Apr;23(4):547-56.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820