CH-0793076-TFA-TP3076-TFA-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemECH-0793076TFACat.No.:HY-107096BSynonyms:TP3076TFA分?式:C??H??F?N?O?分?量:572.53作?靶點(diǎn):Topoisomerase作?通路:CellCycle/DNADamage儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:66.67mg/mL(116.45mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7466mL8.7332mL17.4663mL5mM0.3493mL1.7466mL3.4933mL10mM0.1747mL0.8733mL1.7466mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:5mg/mL(8.73mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性CH-0793076(TP3076)TFA，喜樹堿的六環(huán)類似物，TP300的活性藥物和主代謝物。CH-0793076TFA抑1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE制DNA拓?fù)洚悩?gòu)酶I(DNAtopoisomeraseI)，IC50為2.3μM。CH-0793076TFA對(duì)表達(dá)BCRP(乳腺癌耐藥蛋?)的細(xì)胞也有活性。IC50&TargetTopoisomeraseI2.3μM(IC50)體外研究CH0793076(TP3076)TFA(6daysat37°C)showsantiproliferativeactivityagainstPC-6/BCRPandPC-6/pRCcells,withIC50sof0.35and0.18nM,respectively[1].REFERENCES[1].EndoM,etal.Awatersolubleprodrugofanovelcamptothecinanalogisefficaciousagainstbreastcancerresistanceprotein-expressingtumorxenografts.CancerChemotherPharmacol.2010Jan;65(2):363-71.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559