Hydroxycitric-acid-tripotassium-hydrate-Potassium-citrate-monohydrate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEHydroxycitricacidtripotassiumhydrateCat.No.:HY-W009156CASNo.:6100-05-6Synonyms:Potassiumcitratemonohydrate分?式:C?H?K?O?分?量:324.41作?靶點:ATPCitrateLyase;HIF/HIFProlyl-Hydroxylase作?通路:MetabolicEnzyme/Protease儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗H2O:120mg/mL(369.90mM;Needultrasonic)DMSO:<1mg/mL(insolubleorslightlysoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.0825mL15.4126mL30.8252mL5mM0.6165mL3.0825mL6.1650mL10mM0.3083mL1.5413mL3.0825mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性Hydroxycitricacidtripotassiumhydrate(Potassiumcitratemonohydrate)藤果的主活性成分，也檸檬酸的衍?物。Hydroxycitricacidtripotassiumhydrate可競爭性抑制檸檬酸裂解酶(ATPcitratelyase)，并具有減肥效果。Hydroxycitricacidtripotassiumhydrate有效抑制結(jié)?形成并抑制HIF，具有抗氧化，抗炎和抗腫瘤作?。1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE體外研究HydroxycitricacidshowsanHIFinhibitoryeffectcomparedwiththecontrolgroupinARPE19cellsand661Wcells.HydroxycitricacidcandownregulateHif1aandthedownstreamgenesinARPE19cellsand661Wcells.HydroxycitricacidsuppressesHIF-1αproteinexpressionincreasedbyCoCl2administrationinARPE19cellsand661Wcells[2].Inchickenhepatocytes,Hydroxycitricaciddecreasestheaccumulationoflipiddropletsandacceleratedenergymetabolism.HydroxycitricacidprotectsthecellsfromERstressbyincreasingtheantioxidantstatusandmitochondrialfunctions[2].體內(nèi)研究Hydroxycitricacid(100-200mg/kg)treatmentcouldreducemarkersofrenalimpairment(BloodUreaNitrogenandserumcreatinine).Thereissignificantlylesscalciumoxalatecrystaldepositioninmice(maleC57BL/6Jmice)treatedwithHydroxycitricacid.Hydroxycitricacidattenuatestheoxidativestressinducedbycalciumoxalatecrystallization.Hydroxycitricacidhasinhibitoryeffectsoncalciumoxalate-inducedinflammatorycytokines,suchasMCP-1,IL-1β,andIL-6.Inaddition,Hydroxycitricacidalleviatestubularinjuryandapoptosiscausedbycalciumoxalatecrystals[1].TheadministrationofHydroxycitricacidcansuppressbodyweightgainandfataccumulationinanimals[3].REFERENCES[1].LiuX,etal.Hydroxycitricacidinhibitsrenalcalciumoxalatedepositionbyreducingoxidativestressandinflammation.CurrMolMed.2020Jan3.[2].IbukiM,etal.TherapeuticEffectofGarciniacambogiaExtractandHydroxycitricAcidInhibitingHypoxia-InducibleFactorinaMurineModelofAge-RelatedMacularDegeneration.IntJMolSci.2019Oct11;20(20).pii:E5049.[3].HanS,etal.HydroxycitricAcidTripotassiumInhibitsCalciumOxalateCrystalFormationintheDrosophilaMelanogasterModelofHyperoxaluria.MedSciMonit.2019May17;25:3662-3667.[4].HeymsfieldSB,etal.Garciniacambogia(hydroxycitricacid)asapotentialantiobesityagent:arandomizedcontrolledtrial.JAMA.1998Nov11;280(18):1596-600.McePdfHeightCaution:Producthasnotbeenfullyvalidate