Pralidoxime-iodide-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEPralidoximeiodideCat.No.:HY-B1738ACASNo.:94-63-3分?式:C?H?IN?O分?量:264.06作?靶點(diǎn):AChE作?通路:NeuronalSignaling儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:250mg/mL(946.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.7870mL18.9351mL37.8702mL5mM0.7574mL3.7870mL7.5740mL10mM0.3787mL1.8935mL3.7870mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性Pralidoximeiodide?酰膽堿酯酶(AChE)的活化劑。Pralidoximeiodide能激活神經(jīng)毒劑，抑制?酰膽堿酯酶的活性，其途徑通過結(jié)合神經(jīng)毒劑磷中?的肟部分直接親核攻擊。Pralidoximeiodide有機(jī)磷中毒的解毒劑。體內(nèi)研究Pralidoximeiodide(10-150mg/kg;i.m.)reversesparaoxon-inducedrespiratorytoxicityinmice[3].1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEAnimalModel:MaleF1B6D2mice(toxicbutnon-lethalmodelofdiethylparaoxoninawake,unrestrainedmice)[3]Dosage:10,50,100and150mg/kgAdministration:IntramuscularlyResult:Reversalofdiethylparaoxon-inducedrespiratorytoxicityat150mg/kg.REFERENCES[1].CadieuxCL,etal.Probingtheactivityofanon-oximereactivatorforacetylcholinesteraseinhibitedbyorganophosphorusnerveagents.ChemBiolInteract.2016;259(PtB):133‐141.[2].EyerP,BuckleyN.Pralidoximefororganophosphatepoisoning.Lancet.2006;368(9553):2110‐2111.[3].HouzéP,etal.HighDoseofPralidoximeReversesParaoxon-InducedRespiratoryToxicityinMice.TurkJAnaesthesiolReanim.2018;46(2):131‐138.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589