CDDO-2P-Im-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemECDDO-2P-ImCat.No.:HY-126379CASNo.:1883650-96-1分?式:C??H??N?O?分?量:618.81作?靶點(diǎn):Apoptosis作?通路:Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(404.00mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.6160mL8.0800mL16.1600mL5mM0.3232mL1.6160mL3.2320mL10mM0.1616mL0.8080mL1.6160mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.36mM);ClearsolutionBIOLOGICALACTIVITY?物活性CDDO-2P-ImCDDO咪唑胺類似物，具有化學(xué)預(yù)防作?。CDDO-2P-Im可降低??肺癌模型肺腫瘤的??和1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE嚴(yán)重程度[1]。體外研究CDDO-2P-Im(100nM;4days)inducesdifferentiationofU937cellsat100nM[1].CDDO-2P-ImsuppressesNOproductioninRAW264.7cellswithanIC50of5.8nM[1].ApoptosisAnalysis[1]CellLine:U937cellsConcentration:30nM,100nMIncubationTime:4daysResult:InduceddifferentiationofU937cellsat100nM.體內(nèi)研究CDDO-2P-ImismorestablethanCDDO-Iminpharmacokineticstudies[1].CDDO-2P-Imsignificantlyelevateshemeoxygenase-1(HO-1)andquinonereductase(NQO1)mRNAandproteinlevelsinvariousmousetissuesinvivo[1].CDDO-2P-Im(50-200mg/kg;diet;for16weeks)decreasesthenumber,thesizeandtheseverityoftumorsinA/Jmice[1].AnimalModel:Sevenweek-oldfemaleA/Jmice[1]Dosage:50mg/kg,200mg/kgAdministration:Diet;for16weeksResult:Decreasedthenumber,thesizeandtheseverityoftumors.REFERENCES[1].CaoM,etal.NovelsyntheticpyridylanaloguesofCDDO-Imidazolideareusefulnewtoolsincancerprevention.PharmacolRes.2015Oct;100:135-47.[2].CaoM,etal.NovelsyntheticpyridylanaloguesofCDDO-Imidazolideareusefulnewtoolsincancerprevention.PharmacolRes.2015Oct;100:135-47.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T