Dehydroepiandrosterone-sulfate-DHEA-sulfate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDehydroepiandrosteronesulfateCat.No.:HY-113416CASNo.:651-48-9Synonyms:DHEAsulfate;Prasteronesulfate分?式:C??H??O?S分?量:368.49作?靶點:Others作?通路:Others儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(271.38mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.7138mL13.5689mL27.1378mL5mM0.5428mL2.7138mL5.4276mL10mM0.2714mL1.3569mL2.7138mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(6.78mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.78mM);ClearsolutionBIOLOGICALACTIVITY?物活性Dehydroepiandrosteronesulfate具有神經(jīng)活性的神經(jīng)類醇，通過響神經(jīng)元的遷移、樹突的分枝化和新突觸的形成，在?腦發(fā)育和衰?中發(fā)揮重作?。體外研究Dehydroepiandrosteronesulfate(DHEAS)selectivelyincreasedthelengthofneuritescontainingthedendriticmarkerMAP-2[1].Dehydroepiandrosteronesulfate(DHEAS)hasbeenreportedtoincreaseneuronalexcitability(firingrate)whendirectlyappliedtoseptal-preopticneurons[1].Dehydroepiandrosterone(DHEA)isproducedinprodigiousquantitiesbythehumanadrenal,principallyasthe3-sulfoconjugateDHEAsulfate(DS)duringintrauterinelife[2].Dehydroepiandrosteronesulfate(DHEAS)isgenerallynontoxicandlacksadversesideeffectsevenwhenitisadministeredchronically[3].體內(nèi)研究DHEASchronicadministrationproducesadose-dependenteffectonperformance[3].AnimalModel:Sixty-fourmaleSprague-Dawleyrats,approximately90daysofage(300-400g)[3].Dosage:5,10,or20mg/kg.Administration:Subcutaneousinjectionstarting7dayspost-surgeryand1hpriortoallbehavioraltesting.Result:Significantlyeffectiveinimprovinglatencytoreachtheplatformascomparedtoinjuredratsreceivingvehicle.REFERENCES[1].EEBaulieu,etal.Dehydroepiandrosterone(DHEA)anddehydroepiandrosteronesulfate(DHEAS)asneuroactiveneurosteroids.ProcNatlAcadSciUSA.1998Apr14;95(8):4089-91.[2].CRParkerJr,etal.Dehydroepiandrosteroneanddehydroepiandrosteronesulfateproductioninthehumanadrenalduringdevelopmentandaging.Steroids.1999Sep;64(9):640-7.[3].StuartWHoffman,etal.Thedelayedadministrationofdehydroepiandrosteronesulfateimprovesrecoveryoffunctionaftertraumaticbraininjuryinrats.JNeurotrauma.2003Sep;20(9):859-70.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedical