抑郁癥研究的動(dòng)物模型

抑郁癥研究的動(dòng)物模型基礎(chǔ)01級(jí)陳瑤瑤Iamdepressed.

Metoo.Whyweneedanimalmodels?Thesortsofanimalmodels.Thefuturedevelopmentofanimalmodels.Theusesofanimalmodels

Antidepressantsscreening.

Mechanismstudying神經(jīng)生化功能改變模型應(yīng)激模型條件性飼養(yǎng)模型基因工程動(dòng)物模型獲得性無助模型

(learnedhelpless)慢性溫和應(yīng)激模型

(chronicmildstress)行為絕望模型

(behavioraldespair)Gene-engineeringmiceConventionaltransgenicmiceConditionalgene-targetingmethodsAntisensetargeting5-HT1A受體敲除抗抑郁表型糖皮質(zhì)激素受體基因損傷抗抑郁表型，焦慮相關(guān)的行為減少(有待進(jìn)一步確定)5-HT1B受體敲除拮抗抗抑郁表型，對(duì)SSRI類抗抑郁藥敏感性增加谷氨酸脫羧酶基因敲除抗抑郁表型DA-β-羥化酶基因敲除拮抗抗抑郁表型神經(jīng)細(xì)胞黏附分子基因敲除抗抑郁表型α2A-腎上腺素能受體基因敲除抑郁表型，并拮抗抗抑郁表型TNFα基因敲除抗抑郁表型α2C-腎上腺素能受體基因敲除抗抑郁表型血管緊張素基因敲除抗抑郁表型α2C-腎上腺素能受體基因過表達(dá)抑郁表型腺苷受體基因敲除抗抑郁表型NE轉(zhuǎn)運(yùn)子基因敲除抗抑郁表型速激肽NK1受體基因敲除抗抑郁表型單胺氧化酶A基因敲除抗抑郁表型IL-6基因敲除拮抗抗抑郁表型單胺氧化酶B基因敲除抗抑郁表型多巴胺D5受體基因敲除抗抑郁表型μ阿片受體基因敲除抗抑郁表型DARPP基因敲除對(duì)鹽酸氟西汀敏感性降低δ阿片受體基因敲除抑郁表型CREB突變抗抑郁表型Gα-G-蛋白敲除拮抗抗抑郁表型BDNF條件性基因敲除抗抑郁表型，對(duì)電擊敏感性降低5-HT1A受體敲除抗抑郁表型TrkB基因敲除抗抑郁表型，對(duì)抗抑郁藥敏感性降低展望

實(shí)驗(yàn)動(dòng)物模型是研究抑郁癥必不可少的工具。隨著基因工程技術(shù)的出現(xiàn)，實(shí)驗(yàn)?zāi)Ｐ偷目刹僮餍院投鄻有远即蟠蟾纳屏?。雖然轉(zhuǎn)基因技術(shù)仍存在很多問題，但其仍有著光明的前景。

Reference___________________________________________________________________________________________1．Janne

Gr?nlia,.,RobertMurisonb,d,Bj?rn

Bjorvatnc,d,EliS?rensena,ChiaraM.Portasa,Reidun

Ursina,d，Chronicmildstressaffectssucroseintakeandsleepinrats，BehaviouralBrainResearch150(2004)139–1472．JohnF.Cryan,DanielHoyer,andAthina

Markou，WithdrawalfromChronicAmphetamineInducesDepressive-LikeBehavioralEffectsinRodents，BIOLPSYCHIATRY2003;54:49–583．AndrewHarkin*,JohnP.Kelly,BrianE.Leonard，Areviewoftherelevanceandvalidityofolfactorybulbectomyasamodelofdepression，ClinicalNeuroscienceResearch3(2003)253–2624.Vijayakumar

Mavanjia,b,Subimal

Dattaa,*，Clomipraminetreatmentinneonatalratsaltersthebrainacetylcholinesteraseactivityinadulthood，NeuroscienceLetters330(2002)119–1215.RuthE.Grahna,*,S.E.Hammacka,M.J.Willb,K.A.O’Connora,T.Deakc,P.D.Sparksa,L.R.Watkinsa,S.F.Maiera,Blockadeofalpha1adrenoreceptorsinthedorsalraphenucleuspreventsenhancedconditionedfearandimpairedescapeperformancefollowinguncontrollablestressorexposureinrats,BehaviouralBrainResearch134(2002)387_/3926.PeterGassa,*,HolgerM.Reichardtb,Tatyana

Strekalovaa,FritzHenna,FrancoisTroncheb,Micewithtargetedmutationsofglucocorticoidandmineralocorticoidreceptors:Modelsfordepressionandanxiety?Physiology&Behavior73(2001)811–8257.Alexandre

Urani,SabineChourbaji,FritzA.Henn,PeterGass*，Modelingdepressionwithtransgenicmice:theneurotrophinhypothesisrevisited，ClinicalNeuroscienceResearch3(2003)263–2698．MarianneB.Mu¨

ller*,MartinE.Keck，Geneticallyengineeredmiceforstudiesofstress-relatedclinicalconditions，JournalofPsychiatricResearch36(2002)53–769．EricJ.Nestler,ElizabethGould,Husseini

Manji,Maja

Bucan,RonaldS.Duman,HowardK.Gershenfeld,ReneHen,SusanKoester,IsraelLederhendler,MichaelJ.Meaney,TrevorRobbins,LoisWinsky,andSteveZalcman,PreclinicalModels:StatusofBasicResearchinDepression,BIOLPSYCHIATRY2002;52:503–52810．OvermierJB,SeligmanME.Effectsofinescapableshockuponsubsequentescapeandavoidanceresponding.JCompPhysiol

Psychol1967;63:28–33.neurotransmitterreleaseinananimalmodelofdepression.Neurochem

Int1992;21:29–35.11．BarbaraVollmayr*,FritzA.Henn，Stressmodelsofdepression，ClinicalNeuroscienceResearch3(2003)245–25112．KatzRJ,SchmaltzK.Dopaminergicinvolvementinattention.Anovelanimalmodel.Prog

Neuropsychopharmacol1980;4:585–90.Psychopharmacology13．WillnerP,TowellA,SampsonD,SophokleousS,MuscatR.Reductionofsucrosepreferencebychronicunpredictablemildstressanditsrestorationbyatricyclicantidepressant.Psychopharmacology(Berl)1987;93:358–64.14．WillnerP,MuscatR,PappM.Chronicmildstress-inducedanhedonia:arealisticanimalmodelofdepression.Neurosci

BiobehavRev1992;16:525–34.15．許晶

,李曉秋，慢性應(yīng)激抑郁模型的建立及其評(píng)價(jià)，

ChineseJournalofBehavioralMedicalScience12(1),200316.MoreauJL,ScherschlichtR,JenckF,MartinJR.Chronicmildstressinducedanhedoniamodelofdepression;sleepabnormalitiesandcurativeeffectsofelectroshocktreatment.Behav

Pharmacol1995;6:682–7.17．呂俊華,鐘玲，實(shí)驗(yàn)性抑郁癥動(dòng)物模型的評(píng)價(jià)，中國病理生理雜志ChineseJournalofPathophysiology

2001,17(9):916-91918.JohnF.Cryan,Athina

MarkouandIrwinLucki，Assessingantidepressa