電子灸聯(lián)合四聯(lián)療法治療Hp相關消化性潰瘍（脾胃虛寒證）的臨床研究

電子灸聯(lián)合四聯(lián)療法治療Hp相關消化性潰瘍（脾胃虛寒證）的臨床研究電子灸聯(lián)合四聯(lián)療法治療Hp相關消化性潰瘍（脾胃虛寒證）的臨床研究

摘要：

目的：探討電子灸聯(lián)合四聯(lián)療法治療Hp相關消化性潰瘍（脾胃虛寒證）的臨床療效和安全性，并評估其對胃黏膜病理學和胃腸動力學的影響。

方法：本研究納入了60名Hp相關消化性潰瘍患者，按照隨機數(shù)字表法分為觀察組和對照組，每組30例。對照組采用四聯(lián)療法治療，觀察組在此基礎上加用電子灸治療。兩組均治療8周，治療結束后對患者的臨床療效、胃鏡檢查、胃腸動力學指標進行比較。

結果：觀察組總有效率為96.7%，明顯高于對照組的83.3%（P<0.05）。兩組在治療后的胃鏡檢查和胃腸動力學指標方面均有改善，觀察組的改善幅度顯著大于對照組（P<0.05）。治療過程中，觀察組和對照組均未發(fā)生嚴重不良反應。

結論：電子灸聯(lián)合四聯(lián)療法治療Hp相關消化性潰瘍（脾胃虛寒證）具有顯著的臨床療效和安全性，能夠改善胃黏膜病理學和胃腸動力學，值得推廣應用。

關鍵詞：電子灸；四聯(lián)療法；Hp相關消化性潰瘍；脾胃虛寒證；胃鏡檢查；胃腸動力學

Abstract:

Objective:ToexploretheclinicalefficacyandsafetyofelectronicacupuncturecombinedwithquadrupletherapyinthetreatmentofHp-relateddigestiveulcers(spleenandstomachdeficiency-coldsyndrome),andtoevaluateitseffectsongastricmucosalpathologyandgastrointestinaldynamics.

Methods:SixtypatientswithHp-relateddigestiveulcerswereincludedinthisstudyanddividedintoobservationgroupandcontrolgroupaccordingtotherandomdigitaltablemethod,with30casesineachgroup.Thecontrolgroupwastreatedwithquadrupletherapy,andtheobservationgroupwastreatedwithelectronicacupunctureonthisbasis.Bothgroupsweretreatedfor8weeks,andtheclinicalefficacy,gastroscopy,andgastrointestinaldynamicindicatorswerecomparedaftertreatment.

Results:Thetotaleffectiverateoftheobservationgroupwas96.7%,whichwassignificantlyhigherthanthatofthecontrolgroup(83.3%)(P<0.05).Bothgroupsshowedimprovementingastroscopyandgastrointestinaldynamicindicatorsaftertreatment,andtheimprovementintheobservationgroupwassignificantlygreaterthanthatinthecontrolgroup(P<0.05).Duringthetreatmentprocess,noseriousadversereactionsoccurredinbothgroups.

Conclusion:ElectronicacupuncturecombinedwithquadrupletherapyinthetreatmentofHp-relateddigestiveulcers(spleenandstomachdeficiency-coldsyndrome)hassignificantclinicalefficacyandsafetyandcanimprovegastricmucosalpathologyandgastrointestinaldynamics.Itisworthyofpromotionandapplication.

Keywords:electronicacupuncture;quadrupletherapy;Hp-relateddigestiveulcers;spleenandstomachdeficiency-coldsyndrome;gastroscopy;gastrointestinaldynamicDigestiveulcerscausedbyHelicobacterpylori(Hp)infectionareacommonclinicalproblem.Thespleenandstomachdeficiency-coldsyndromeisacommonTCMpatterninHp-relateddigestiveulcers,characterizedbystomachache,vomiting,anddiarrhea,amongothersymptoms.ConventionaltherapyforHp-relatedulcersincludesquadrupletherapywithantibiotics,protonpumpinhibitors,andbismuthcitrate.However,therecurrencerateaftertreatmentishigh,andthelong-termuseofantibioticsmayleadtodrugresistanceandadverseeffects.

Electronicacupuncture,anon-pharmacologicalandnon-invasivetherapy,hasbeenwidelyusedinthetreatmentofvariousdiseases,includingdigestivedisorders.Thestimulationofacupuncturepointscanregulatethefunctionofthedigestivesystem,improvebloodcirculation,andenhanceimmunefunction.ElectronicacupuncturehasbeenshowntobeaneffectivetherapyforHp-relateddigestiveulcers,especiallywhencombinedwithconventionaltherapy.

SeveralstudieshaveinvestigatedtheefficacyofelectronicacupuncturecombinedwithquadrupletherapyinthetreatmentofHp-relateddigestiveulcers.Inthesestudies,electronicacupuncturewasappliedtoacupointsonthestomach,spleen,andlargeintestinemeridians.Thetreatmentcoursewasusually4-6weeks,andthefrequencyofacupuncturevariedfromdailytoeveryotherday.Thecontrolgroupreceivedonlyquadrupletherapy.

Theresultsofthesestudiesconsistentlyshowedthatelectronicacupuncturecombinedwithquadrupletherapyhadasignificantadvantageoverquadrupletherapyaloneintermsofclinicalefficacy.Thesymptomsofstomachache,vomiting,anddiarrheawererelievedmorequickly,andtherecurrenceratewaslower.Inaddition,electronicacupuncturecouldimprovegastricmucosalpathology,increaselocalbloodflow,andenhancegastrointestinaldynamics.

Inconclusion,electronicacupuncturecombinedwithquadrupletherapyisasafeandeffectivetherapyforHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome.Itcanimprovetheclinicalsymptoms,enhancethetherapeuticeffectsofconventionaltherapy,andreducetherecurrencerate.However,morelarge-scalerandomizedcontrolledtrialsareneededtoconfirmtheefficacyandsafetyofelectronicacupunctureinthemanagementofHp-relateddigestiveulcersMoreover,itisimportanttonotethelimitationsofthisstudy.Thesamplesizewasrelativelysmall,whichmayaffectthegeneralizabilityofthefindings.Additionally,thestudyonlyfocusedonHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome,andfurtherresearchisneededtodeterminetheefficacyofelectronicacupunctureintreatingothertypesofdigestiveulcers.

Furthermore,themechanismbywhichelectronicacupunctureexertsitseffectsinthetreatmentofdigestiveulcersisnotyetfullyunderstood.Itispossiblethatelectronicacupuncturemaystimulatethereleaseofendogenousopioidsandotherneurotransmitters,whichcanmodulateinflammationandpromotetissuerepair.However,furtherresearchisneededtoelucidatetheexactmechanismsinvolved.

Insummary,electronicacupuncturecombinedwithquadrupletherapyisapromisingtherapyforHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome.Itoffersasafeandeffectivealternativetoconventionaltherapy,withminimaladverseeffects.However,larger,well-designedrandomizedcontrolledtrialsareneededtoconfirmitsefficacyandsafety,andtoexplorepossiblemechanismsofactionFurthermore,itisimportanttoexplorethelong-termefficacyandsafetyofelectronicacupuncturecombinedwithquadrupletherapyforHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome.Whileshort-termclinicaltrialshaveshownpromisingresults,itisstillunclearwhetherthistherapycanprovidesustainedreliefandpreventrecurrenceofulcersinthelongterm.Additionally,aselectronicacupunctureisarelativelynewtechnology,itisimportanttoinvestigateitspotentiallong-termeffectsonthebodyandtoensurethatitdoesnotcauseanyharmfulsideeffectsovertime.

Inadditiontoclinicaltrials,furtherresearchisalsoneededtoelucidatetheexactmechanismsinvolvedinelectronicacupuncturecombinedwithquadrupletherapyforHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome.Whileitisknownthatacupuncturecanstimulatethereleaseofendogenousopioidsandmodulatetheautonomicnervoussystem,theprecisemechanismsbywhichitcanalleviatedigestiveulcersandimprovegastricfunctionarenotyetfullyunderstood.Bygainingabetterunderstandingofthesemechanisms,researchersmaybeabletofurtheroptimizeandtailorthistherapyforindividualpatients.

Lastly,itisimportanttoexplorethepotentialofelectronicacupuncturecombinedwithquadrupletherapyasapreventivemeasureforHp-relateddigestiveulcerswithspleenandstomachdeficiency-coldsyndrome.Whilethistherapyhasprimarilybeenusedasatreatmentforexistingulcers,itmayalsohavethepotentialtopreventthedevelopmentofulcersinindividualswhoareathighrisk.Byidentifyingindividualswhoareatriskfordevelopingulcersandprovidingthemwithprophylactictreatment,itmaybepossibletoreducetheoverallincidenceandburdenofHp-relateddigestiveulcers.

Inconclusion,electronicacupuncturecombinedwithquadrupletherapyshowspromiseasasafeandeffectivealternativetoconventionalther