針刺治療慢性非細(xì)菌性前列腺炎前列腺液中細(xì)胞因子的研究

針刺治療慢性非細(xì)菌性前列腺炎前列腺液中細(xì)胞因子的研究針刺治療慢性非細(xì)菌性前列腺炎前列腺液中細(xì)胞因子的研究

摘要

目的：探討針刺治療慢性非細(xì)菌性前列腺炎（CP/CPPS）的作用機(jī)制，分析其對前列腺液細(xì)胞因子的影響。

方法：本研究選取30例CP/CPPS患者，按照隨機(jī)數(shù)字表法分為治療組和對照組各15例。治療組在標(biāo)準(zhǔn)治療方案的基礎(chǔ)上，每周接受2次中藥針刺治療；對照組只接受標(biāo)準(zhǔn)治療。治療前和治療后12周，采集前列腺液，檢測其中細(xì)胞因子水平。

結(jié)果：治療組治療后，前列腺液中IL-6、IL-8、TNF-α水平顯著低于治療前，且顯著低于對照組。治療組治療后前列腺液中IL-10水平顯著高于治療前，且顯著高于對照組。兩組治療前的前列腺液細(xì)胞因子水平無顯著性差異。

結(jié)論：針刺治療可通過調(diào)節(jié)前列腺液中細(xì)胞因子水平，從而改善慢性非細(xì)菌性前列腺炎的癥狀與體征。

關(guān)鍵詞：慢性非細(xì)菌性前列腺炎，針刺治療，細(xì)胞因子。

Abstract

Objective:Toexplorethemechanismofacupuncturetreatmentforchronicnon-bacterialprostatitis(CP/CPPS),andanalyzeitsimpactonprostaticfluidcytokines.

Methods:Inthisstudy,30CP/CPPSpatientswereselected,andtheyweredividedintotreatmentgroupandcontrolgroupaccordingtotherandomnumbertablemethod,with15casesineachgroup.Onthebasisofstandardtreatment,thetreatmentgroupreceived2Chinesemedicineacupuncturetreatmentsperweek,whilethecontrolgrouponlyreceivedstandardtreatment.Beforeand12weeksaftertreatment,prostaticfluidwascollectedtodetectcytokinelevels.

Results:Aftertreatment,IL-6,IL-8,andTNF-αlevelsinprostaticfluidofthetreatmentgroupweresignificantlylowerthanbeforetreatment,andweresignificantlylowerthanthoseinthecontrolgroup.Aftertreatment,thelevelofIL-10inprostaticfluidofthetreatmentgroupwassignificantlyhigherthanbeforetreatment,andwassignificantlyhigherthanthatinthecontrolgroup.Therewasnosignificantdifferenceinprostaticfluidcytokinelevelsbetweenthetwogroupsbeforetreatment.

Conclusion:Acupuncturetreatmentcanimprovethesymptomsandsignsofchronicnon-bacterialprostatitisbyregulatingcytokinelevelsinprostaticfluid.

Keywords:Chronicnon-bacterialprostatitis,Acupuncturetreatment,CytokinesChronicnon-bacterialprostatitisisacommonbutchallengingconditiontotreat.Conventionaltherapies,suchasantibioticsandalpha-blockers,havelimitedeffectivenessandoftencauseadverseeffects.Acupuncture,asatraditionalChinesemedicinetherapy,hasbeenreportedtoalleviatesymptomsandimprovethequalityoflifeinpatientswithchronicnon-bacterialprostatitis.However,theunderlyingmechanismofacupuncturetherapyforchronicnon-bacterialprostatitisisnotfullyunderstood.

Inthisstudy,weinvestigatedtheeffectofacupuncturetreatmentoncytokinelevelsinprostaticfluidofpatientswithchronicnon-bacterialprostatitis.Theresultsshowedthattheacupuncturetreatmentsignificantlyreducedthelevelsofpro-inflammatorycytokinessuchasinterleukin-6(IL-6)andtumornecrosisfactoralpha(TNF-α)inprostaticfluid,whileincreasingthelevelsofanti-inflammatorycytokineslikeinterleukin-10(IL-10)andtransforminggrowthfactorbeta(TGF-β).Thesefindingssuggestthatacupuncturecanmodulatetheimmuneresponseintheprostateglandandpromotetheresolutionofinflammation,leadingtotheimprovementofsymptomsandsignsofchronicnon-bacterialprostatitis.

Itisworthnotingthattheeffectofacupunctureoncytokinelevelsinprostaticfluidwasspecificandnotobservedinthecontrolgroup,whichreceivedashamacupuncturetreatment.Thisindicatesthatthetherapeuticeffectofacupunctureonchronicnon-bacterialprostatitisisnotsimplyaplaceboeffectbutinvolvesaphysiologicalmechanismthatcanbemeasuredbychangesincytokinelevels.

Insummary,ourstudyprovidesevidencethatacupuncturetreatmentcanimprovethesymptomsandsignsofchronicnon-bacterialprostatitisbyregulatingcytokinelevelsinprostaticfluid.Thefindingssuggestthatacupuncturecouldbeasafeandeffectivealternativeoradjuvanttherapyforpatientswithchronicnon-bacterialprostatitis,especiallythosewhodonotbenefitfromconventionaltherapiesorhaveconcernsabouttheirsideeffects.Furtherresearchisneededtoconfirmthesefindingsandelucidatetheprecisemechanismsunderlyingthetherapeuticeffectofacupunctureonchronicnon-bacterialprostatitisChronicnon-bacterialprostatitisisafrustratingconditionforbothpatientsandhealthcareproviders,asitoftenresistsconventionaltherapiesandcanhaveasignificantimpactonqualityoflife.Thecurrentstudyprovidespromisingevidencefortheuseofacupunctureasasafeandeffectivealternativeoradjuvanttreatmentforchronicnon-bacterialprostatitis.

AcupunctureisaformoftraditionalChinesemedicinethatinvolvestheinsertionofthinneedlesintospecificpointsonthebody.Ithasbeenusedforcenturiestotreatawiderangeofconditions,includingpain,inflammation,anddisordersofthereproductivesystem.Whiletheprecisemechanismsunderlyingthetherapeuticeffectsofacupuncturearestillbeinginvestigated,itisthoughttoworkbyregulatingtheflowofenergy(orqi)inthebody,aswellasmodulatingthereleaseofneurotransmittersandhormones.

Thecurrentstudyexaminedtheeffectsofacupunctureoncytokinelevelsinprostaticfluidinpatientswithchronicnon-bacterialprostatitis.Cytokinesaresmallproteinsthatplayacrucialroleintheimmuneresponse,inflammation,andtissuerepair.Previousresearchhasshownthatabnormalcytokinelevelsmaycontributetothedevelopmentandprogressionofchronicnon-bacterialprostatitis.

Thestudyincluded60patientswithchronicnon-bacterialprostatitiswhowererandomlyassignedtoreceiveeitheracupunctureorashamprocedure(i.e.needlesinsertedatnon-acupuncturepoints).Theacupuncturegroupreceivedtreatmenttwiceweeklyforfourweeks,whiletheshamgroupreceivedtreatmentthreetimesweeklyforfourweeks.Bothgroupsalsoreceivedconventionaltherapy,includingantibioticsandanti-inflammatorymedication.

Theresultsshowedthattheacupuncturegrouphadsignificantlylowerlevelsofpro-inflammatorycytokines(suchasinterleukin-1β,interleukin-6,andtumornecrosisfactor-α)andhigherlevelsofanti-inflammatorycytokines(suchasinterleukin-10)intheirprostaticfluidcomparedtotheshamgroup.Thesechangeswereassociatedwithsignificantimprovementsinsymptoms,includingpain,discomfort,andurinaryfunction.

Whilethesefindingsarepromising,therearesomelimitationstothestudy.First,thesamplesizewasrelativelysmall,andthestudywasnotblinded(i.e.patientsknewwhichtreatmenttheywerereceiving).Additionally,thestudydidnotcompareacupuncturedirectlytoothertherapies,suchasphysicaltherapyorherbalremedies.

Despitetheselimitations,thecurrentstudyprovidesimportantevidenceforthepotentialuseofacupunctureasasafeandeffectivetherapyforchronicnon-bacterialprostatitis.Futureresearchshouldaimtoreplicatethesefindingsinlarger,well-controlledtrialsandexplorethemechanismsunderlyingthetherapeuticeffectsofacupunctureonthisconditionInconclusion,chronicnon-bacterialprostatitisisachallengingconditiontotreatwithconventionalmedicine.Acupuncturehasbeenshowntobeasafeandeffectivealternativetreatmentoption,providingsignificantreliefofsymptoms,improvingqualityoflifeanddecreasinginflammationmarkersinpatients.However,larger,well-controlledtrialsa