常見藥物中間體

常見藥物中間體Entecavir恩替卡韋中間體：第1步：Cyclopenten-1-ol,2-[(phenylmethoxy)methyl]-,(1R-trans)CASNo:188399-48-6第2步：(1S,2R,3S,5R)-2-(benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-olCASNo:117641-39-1第3步：6-Oxabicyclo[3.1.0]hexane,3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-,(1S,2R,3S,5R)CASNo110567-22-1第4步：(1S,2S,3S,5S)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanolcas:142217-77-4第5步：(2R,3S,5S)-3-(benzyloxy)-5-(6-(benzyloxy)-2-((4-methoxyphenyl)diphenylmethylamino)-9H-purin-9-yl)-2-(benzyloxymethyl)cyclopentanolCASNo：142217-78-5第6步：(2R,3S,5S)-3-(benzyloxy)-5-(6-(benzyloxy)-2-((4-methoxyphenyl)diphenylmethylamino)-9H-purin-9-yl)-2-(benzyloxymethyl)cyclopentanoneCASNo142217-79-6第7步：6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amineCASNo142217-80-9第8步：6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-9H-purin-2-amineCASNo204845-95-4釓雙胺一水物122795-43-1阿折地平中間體阿折地平中間體CAS：18621-17-5阿折地平中間體CAS：116574-14-2阿折地平中間體CAS：170749-59-4阿折地平中間體CAS：39562-25-9Anagrelide阿那格雷中間體N-（6-硝基-2.3-二氯芐基）甘氨酸乙酯鹽酸鹽N-（2.3-dichloro-6-nitrobenzyl）glycineHCl 含量：98%以上99%N-（6-氨基-2.3-二氯芐基）甘氨酸乙酯EthylN-（6-amino-2.3-dichlorobenzyl）glycine70406-92-7Prasugrel普拉格雷側(cè)鏈（中間體）150322-73-9含量：98%以上Adapalene阿達(dá)帕林中間體：2-（1-Adamantyl）-4-bromophenol2-（1-金剛烷基）-4-溴苯酚（1-Adamantyl）-4-bromoanisole2-（1-金剛烷基）-4-溴苯甲醚Methyl6-[3-（1-adamantyl）-4-methoxyphenyl]-2-naphthoate6-[3-（1-金剛烷基）-4-甲氧基苯基]-2-萘甲酸甲酯（5-Bromo-2-Methoxyphenyl）-adamantaneCASNO.104224-63-71-（5-溴-2-甲氧基苯基）金剛烷Methyl6-bromo-2-naphthoate6-溴－2－萘甲酸甲酯AdefovirDipivoxil阿徳福韋酯中間體：9-[2-（Diethylphosphonomethoxy）ethyl]adenine9-[2-（二乙基膦酸基甲氧基）乙基]腺嘌呤9-（2-Phosphonylmethoxyethyl]adenine（Adefovir）9-[2-（膦酸基甲氧基）乙基]腺嘌呤（阿德福韋）AmorolfineHCl鹽酸阿莫羅芬中間體：3-[1,1-Dimethylphenyl-4-]-2-methyl-propionicacid3-[1,1-二甲基苯基-4-]-2-甲基-丙酸Anagrelide阿那格雷中間體：EthylN-（2,3-dichloro-6-aminobenzyl）glycineN—（2,3—二氯一6—氨基一芐基）甘氨酸乙酯Aripiprazole阿立哌唑中間體:（2,3-Dichloro-phenyl）-piperazinehydrobromide1-（2,3-二氯苯基）-哌嗪氫溴酸鹽7-(4-Bromo-butoxy)-3,4-dihydro-2(1H)-quinolinone7-(4-溴丁氧基)-3,4-二氫-2(1H)-喹啉酮BrompheniramineMaleate馬來酸溴苯那敏中間體：a-(p-Bromophenyl)-a-(B-dimethylaminoethyl)-2-pyridylacetonitrilemaleatea-對(duì)溴苯基-a-(B-二甲基氨基乙基)-2-吡啶乙腈馬來酸鹽CandesartanCilexetil坎地沙坦酯中間體：Cyclohexyl1-chloroethylcarbonate環(huán)己基1-氯乙基碳酸酯Ethoxy-1-[[2'-(1H-tetrezol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylicacid(Candesartan)1-[[2'-(1-H-四氮唑-5-基)聯(lián)苯-4-基]甲基卜2-乙氧基-苯并咪唑-7-羧酸(坎地沙坦)Cefepime頭抱吡肟中間體：(6R,7R)-7-Amino-3-[(1-methyl-1-pyrrolidino)methyl]ceph-3-em-4-carboxylatehydriodicacid7-氨基-3-[(1-甲基-1-吡咯烷基)甲基]頭抱-3-烯基-4-羧基氫碘酸鹽(頭抱吡肟母核)Cefutibuten頭抱布烯中間體：(E/Z)(4-2-Methyl-buten)4-(2-benzyloxycarbonyolaminothiazol-4-yl)-4-carboxy-3-butyrate(Cefutibutensidechain)(順/反)4－(2－芐氧羰基氨基噻唑－4－基)－4－羧基－3－丁烯酸(4－2－甲基－2－丁烯)酯(頭抱布烯側(cè)鏈)Dofetilide多非利特中間體：[4-Nitrophenoxy]ethylchloride4-(2-氯乙氧基)硝基苯N-Methyl-4-nitrophenethylaminehydrochlorideCAS:166943-39-14-硝基-B-苯乙胺鹽酸鹽N-Methyl-N-[2-(4-nitrophenoxy)ethyl]-4-nitrophenylamineN-甲基-N-[2-(4-硝基苯氧基)乙基]-4-硝基苯乙胺EscitalopramOxalate草酸依地普侖中間體：(-)-4-[4-(Dimethylamino)-1-(4'-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile,Tosyltartaricacidsalt(-)-4-[4-二甲氨基-1-(4-氟苯基)-1-羥基-1-丁基]-3-羥甲基苯乙腈，苯甲?；剖猁}Finasteride非那雄胺中間體:Oxo-4-androstene-17p-carboxylicacid3-氧代-4-雄甾烯-17^-羧酸Fluoxetine氟西汀中間體：N-Methyl-3-phenyl-3-hydroxypropylamineN-甲基-3-苯基-3-羥基丙胺Lafutidine拉咲替丁/拉夫替丁中間體：Bromo-4-(1-piepridinomethyl)pyridine2-溴-4-(1-哌啶基甲基)吡啶p-nitrophenyl2-[(furanylmethyl)sulfinyl]aceticacid(ForLafutidine)a-(2-咲喃甲基亞磺?；?乙酸-(4-硝基苯酚)酯CAS號(hào)為123855-55-0N-{4-[4-(1-Piperidinomethyl)pyridyl-2-oxy]-cis-2-buten}phthalimidemaleateCASNo.146447-26-9N-{4-[4-(1-哌啶甲基)吡啶-2-氧卜順-2-丁烯基}鄰苯二甲酰胺，馬來酸鹽(Furfurylsulfinyl)aceticacidp-nitrophenylester2-咲喃甲基亞磺?；宜?p-硝基苯Levetiracetam左乙拉西坦中間體：L-2-AminobutanamideL—2—氨基丁酰胺Levosimendan左西孟旦中間體：6-(4-Aminophenyl)-4，5-dihydro-5-methyl-3(2H)-pyridazinoneCAS:36725-28-76-(4-氨基苯基)-5-甲基-4,5-二氫-3(2H)-噠嗪酮2，7-dichloro-9H-FluoreneCAS: [7012-16-0](-)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone(-)-6-(4-氨基苯基)-5-甲基-4,5-二氫-3(2H)-噠嗪酮Liranaftate利拉萘酯中間體：Methoxy-6-methylaminopyridine2-甲氧基-6-甲氨基吡啶Tetrahydro-2-naphthol四氫-2-萘酚Nevirapine奈韋拉平中間體：Chloro-3-amino-4-methylpyridine2－氯－3－氨基－4－甲基吡啶Nifekalant尼非卡蘭中間體：6-Chloro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione1,3-二甲基-6-氯尿嘧啶N-(2-Hydroxyethyl)-N-[3-(4-nitrophenyl)propyl]amineN-(2-羥乙基)-3-(4-硝基苯基)丙胺Pramipexole普拉克索中間體：[(N-Benzoyl)amino]-cyclohexanone4-[(N-苯甲?；?-氨基卜環(huán)己酮(S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole(S)-2-氨基-6-丙胺基-4,5,6,7-四氫苯并噻唑Prulifloxacin普盧利沙星中間體：Ethyl6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate6,7-二氟一1—甲基一4—氧代一4H—[1,3]硫氮雜環(huán)丁烷[3,2-a]喹啉一3—甲酸乙酯Ethyl6-fluoro-7-(1-piperazinyl)-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate6—氟一7—(1—哌啶基)一1—甲基一4—氧代一4H—[1,3]硫氮雜環(huán)丁烷[3,2-a]喹啉一3—甲酸乙酯6-Fluoro-7-(1-piperazinyl)-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylicacid6—氟一7—(1—哌啶基)一1—甲基一4—氧代一4H—[1,3]硫氮雜環(huán)丁烷[3,2-a]喹啉一3—甲酸Racecadotril消旋卡多曲中間體：Acetylthio-2-benzylpropanoicacid芐基-3-硫代乙酰基丙酸Glycinebenzylesterp-tosylate甘氨酸芐酯對(duì)甲苯磺酸鹽Risperidone利培酮中間體：6-Fluoro-3-(tetrahydropyridine-4-yl)benzo[b]isoxazol6-氟-3-(4-哌啶基)-1,2-苯并異噁唑(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidine-4-one(2-氯乙基)-6,7,8,9-四氫-2-甲基-4H吡啶并[1,2-a嘧啶-4-酮Rosiglitazone羅格列酮中間體：{4-{2-[Methyl—(2—pyridyl)amino]ethoxy}benzal}-2,4-thiazole-dione5-{4-{2-[甲基-(2-吡啶基)氨基]乙氧基}芐叉}-2,4-噻唑二酮Thiazolidinedione噻唑二酮RoxatidineAcetateHCl鹽酸羅沙替丁醋酸酯中間體：(1-Piperidinylmethyl)phenol3—(1—哌啶基甲基)苯酚N-{3-[3-(1-Piperidinylmethyl)phenoxy]propyl}amineN-{3-[3-(1-哌啶基甲基)苯氧基]}丙胺Telmisartan替米沙坦中間體：N-Methyl-O-phenylenediaminedihydrochlorideN-甲基鄰苯二胺鹽酸鹽N-Propyl-4-methyl-6-carboxybenzimidazole2-丙基-4-甲基-6-羧基苯并咪唑tert-Buthyl4'-methylbiphenyl-2-carboxylate4'-甲基聯(lián)苯-2-甲酸叔丁酯tert-Buthyl4'-(bromomethyl)biphenyl-2-carboxylate4'-溴甲基聯(lián)苯-2-甲酸叔丁酯TrospiumChloride曲司氯銨中間體：a-Hydroxy-a-phenylbenzeneaceticacida-羥基-a-苯基苯乙酸Voriconazole伏立康唑中間體：(1-Bromo-ethyl)-4-chloro-5-fluoropyrimidine6-(1-溴乙烷)-4-氯-5-氟嘧啶(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone(2,4-二氟苯基)-2-(1H-1,2,4-三唑)-1-基)乙酮(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-yl)-2-butanolhydrochloride(2R,3S/2S,3R)-3-(4-氯-5-氟嘧啶-6-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇鹽酸鹽(2R,3S/2S,3R)-3-(5-Fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol(2R,3S/2S,3R)-3-(5—氟嘧啶一4—基)一2—(2,4—二氟苯基)一1—(1H—1,2,4—三唑一1—基)?。?－醇乙prasidone齊拉西酮中間體：(1-Piperazinyl)-1,2-benzisothiazolehydrochloride3-(1-哌嗪基)-1,2-苯并異噻唑鹽酸鹽Zolmitriptan佐米曲坦/佐米曲普坦中間體：(S)-4-(4-Nitrobenzyl)-1,3-oxazolidin-2-one(S)-4-(4-硝基芐基)-1.3-噁唑-2-酮Memantine美金剛中間體：1-bromo-3,5-dimethyladamantane1-溴-3,5-二甲基金剛烷甲磺酸伊馬替尼及中間體甲磺酸伊馬替尼220127-57-1Imatinibbase152459-95-5[(4-methyl-1-piperaziny)methyl]benzoicacid106261-49-8[(4-methyl-1-piperaziny)methyl]benzoicaciddihydrochloride106261-48-7N-(5-amino-2-methylphenl)-4-(3-pyridyl)-2-pyrimidine-amine152460-10-1舒尼替尼及中間體舒尼替尼341031-54-7Sunitinibbase557795-19-4Fluoro-1,3-dihydro-indol-2-one56341-41-4tert-butyl4-ethyl3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate86770-31-2(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylicacid5442-91-1ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate2199-51-1ethyl5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate2199-59-9Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylicacid253870-02-9((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid356068-93-4拉帕替尼及中間體拉帕替尼388082-78-8Lapatinibbase231277-92-2Amino-5-iodo-benzoicacid5326-47-6Iodoquinazolinone16064-08-7Chloro-6-iodo-quinazoline98556-31-1Chloro-1-(3-fluoro-benzyloxy)-4-nitro-benzene443882-99-3Chloro-4-(3-fluoro-benzyloxy)-phenylamine202197-26-0N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine231278-20-9[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)quinazolin-6-yl]-2-furaldehyde231278-84-5尼羅替尼及中間體尼羅替尼641571-10-0Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid641569-94-0Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacidethylester[(Aminoiminomethyl)amino]-4-methyl-benzoicacidethylestermononitrate641569-96-2(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline641571-11-1達(dá)沙替尼及中間體達(dá)沙替尼863127-77-92-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide302964-24-52-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide302964-08-5吉非替尼及中間體吉非替尼184475-35-2methyl2-amino-4,5-dimethoxybenzoate26759-46-66,7-dimethoxyquinazolin-4(3H)-one13794-72-4hydroxy-7-methoxyquinazolin-4(3H)-one179688-52-93,4-dihydro-7-methoxy-4-oxoquinazolin-6-ylacetate179688-53-0chloro-7-methoxyquinazolin-6-ylacetate179688-54-1(HCl)230955-75-6(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylacetate184475-70-5(HCl)788136-89-0(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol184475-71-64-(3-chloropropyl)morpholine7357-67-7埃羅替尼及中間體埃羅替尼/厄羅替尼183319-69-9Erlotinibbase183321-74-6ethyl3,4-dihydroxybenzoate3943-89-3ethyl3,4-bis(2-methoxyethoxy)benzoate183322-16-9ethyl4,5-bis(2-methoxyethoxy)-2-nitrobenzoate179688-26-7ethyl4,5-bis(2-methoxyethoxy)-2-aminobenzoate179688-27-86,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one179688-29-04-Chloro-6,7-(2-methoxyethoxy)-quinazoline183322-18-1卡那替尼289499-45-2凡德他尼443913-73-3索拉非尼索拉非尼475207-59-14-CHLORO-(2-(METHYLAMINO)-CARBONYL)-PYRIDINE220000-87-34-(4-aminophenoxy)-N-methylpicolinamide284462-37-9免疫抑制劑FTY720475207-59-1抗糖尿病藥西他列汀486460-32-6維達(dá)列汀274901-16-5鹽酸度洛西汀及中間體鹽酸度洛西汀136434-34-9(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine132335-46-7(HCl)阿利吉侖及中間體阿利吉侖173334-58-2Aliskirenbase173334-57-1(2S,4S,5S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4,5-dihydroxy-2-isopropylpentanamide(R)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine110117-71-02-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene)172900-69-52-(aminomethyl)-2-methylpropanamide324763-51-1(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one145589-03-31-(((S)-2-(bromomethyl)-3-methylbutoxy)methyl)benzene172901-00-7卡巴拉汀及中間體酒石酸卡巴拉汀129101-54-8卡巴拉汀堿123441-03-2N-Ethyl-N-Methylcarbamoylchloride42252-34-6[1-(Dimethylamino)ethyl]phenol105601-04-5(s)-3-(1-(dimethylamino)ethyl)phenol139306-10-8羅庫溴銨及中間體羅庫溴銨119302-91-95a-androsta-2-en-17-one963-75-72-(4-morpholinyl)-16-(1-pyrrolidinyl)-5-androstane-3,17-diol119302-20-4艾拉莫德及中間體艾拉莫德123663-49-03-硝基-4-苯甲氧基茴香醚82780-78-73-氨基-4-苯甲氧基茴香醚82780-77-63-甲基磺酰胺基-4-苯氧基茴香醚88381-56-7a-氨基-2-甲氧基-4-甲磺酰胺基-5-苯氧苯乙酮鹽酸鹽149436-41-9氨來占諾及其中間體6-異丙基-4-氧代-4H-1-苯并吡喃-3-甲醛（取代苯并吡喃一3—甲醛）CASNO:49619-58-16-異丙基-4-氧代-4H-1-苯并吡喃-3-甲腈（取代苯并吡喃一3—甲腈）CASNO:50743-32-3氨來占諾乙酯瑞舒伐他汀鈣及其中間體4—（4-氟苯基）一6—異丙基一2—（N—甲基一N—甲磺酰氨基）