藥物化學英文版-抗腫瘤藥

MedicinalChemistry

AntineoplasticAgents班級：制藥一班學生：張航AntineoplasticAgentsTumorformation

1introduction2BasictheoryAntineoplasticAgents

1AgentsDirectlyActingonDNA

2AgentsInterferingwithDNASynthesis3AntimitoticAgents4AgentsonSignalTransductionPathway

MechanismofTunor(Erlotinib)Tumorprevention1Primarypreventionoftumor

2Secondarypreventionoftumor

3Tertiarypreventionoftumor

AntineoplasticAgentsTumorformation1、IntroductionAntineoplasticAgents1)BasiccharacteristicsofTumorcells——cellularatypia2)Biologicalbehavioroftumors——heterogeneityAntineoplasticAgentsNormalcellCarcinogen-inducedchangeTumorcellvariantAntineoplasticAgentsTumorformation

2Basictheory

1)Cancerisageneticdisease

2)MonoclonalexpansionofTumorcells3)Oncogeneactivationortumorsuppressorgeneinactivation4)Long-term,phased,multiplemutationsaccumulatedintheprocess5)TheresultoflossoffunctionofimmunesurveillanceAntineoplasticAgentsAntineoplasticAgents

1)AgentsDirectlyActingonDNAAlkylatingAgentsPlatinumComplexesTopoisomeraseInhibitors2)AgentsInterferingwithDNASynthesisAntifolatesPyrimidineAntimetabolitesPurineAntimetabolitesAntineoplasticAgents3)AntimitoticAgentsAntitumorAgentsHavingOneBinding-PointonTubulinAntitumorAgentsHavingTwoBinding-PointonTubulinAntitumorAgentsActingonthePolymerizationStateofMicrotube4)AgentsonSignalTransductionPathwayMechanismofTunor

ProteinKinaseInhibitorsProteasomeInhibitorsAntineoplasticAgentsErlotinibandGefitinibAntineoplasticAgentsAntineoplasticAgentsErlotinib

Tarceva?(erlotinib),aonce-a-daypill,wasoneofthefirsttargetedtreatmentsapprovedbytheU.S.FoodandDrugAdministration(FDA)specificallydesignedtotargettheepidermalgrowthfactorreceptor(EGFR)pathway.TarcevahasbeenshowntohelpsomepeoplewithadvancedNSCLCandadvancedpancreaticcancerlivelonger.

NSCLC(Non-small-cellcarcinoma)AntineoplasticAgentsEr