SN-38-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESN-38(Standard)Cat.No.:HY-13704RCASNo.:86639-52-3分子式:C??H??N?O?分子量:392.4作用靶點(diǎn):DrugMetabolite;Topoisomerase;ADCCytotoxin;Autophagy作用通路:MetabolicEnzyme/Protease;CellCycle/DNADamage;Antibody-drugConjugate/ADCRelated;Autophagy儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性SN-38(Standard)是SN-38的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。SN-38是拓?fù)洚悩?gòu)酶I(TopoisomeraseI)抑制劑伊立替康的活性代謝產(chǎn)物。SN-38抑制DNA合成和RNA合成的IC50分別為0.077和1.3μM。SN-38是sacituzumabgovitecan(HY-132254)的有效載荷。IC50&TargetTopoisomeraseI[1]REFERENCESWallinA,etal.AnticancereffectofSN-38oncoloncancercelllineswithdifferentmetastaticpotential.OncolRep.2008Jun;19(6):1493-8.JensenNF,etal.CharacterizationofDNAtopoisomeraseIinthreeSN-38resistanthumancoloncancercelllinesrevealsanewpairofresistance-associatedmutations.JExpClinCancerRes.2016Mar31;35:56.KawatoY,etal.IntracellularrolesofSN-38,ametaboliteofthecamptothecinderivativeCPT-11,intheantitumoreffectofCPT-11.CancerRes.1991;51(16):4187-4191.AaronTJacobs,etal.Targetedtherapyforbreastcancer:Anoverviewofdrugclassesandoutcomes.BiochemPharmacol.2022Oct:204:115209.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021