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1、第一頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Fetal Cardiology Cardiac anomalies are the most frequently overlooked group of abnormalities Congenital heart disease = 0.8% of all pregnancies4% one sibling affected; 10% two siblings affected9% father affected12% mother affected Causes 50% deaths from congenital disease第二頁,共七
2、十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Fetal Cardiology Risk Factors for congenital heart disease: Family history Recurrence risk (hypoplastic left heart as high as 13.5%) Nongestational DM Maternal infection (rubella) Lupus Drugs (anticonvulsants, etoh, amphetamines, ocp, vit A, steroids, etc.)第三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Fetal
3、 Cardiology AIUM / ACR standards in the 2nd and 3rd trimesters include: Four chamber view Position of fetal heart in the thorax LVOT and RVOT not yet part of standards 4 chamber view alone: 33-63% sensitive With outflow tracts: 83-85% sensitive 2第四頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)GOALS Review normal cardiac anat
4、omy and its sonographic appearance (four chamber, LVOT, RVOT) Explore diagnostic pitfalls Review the appearance of more common structural cardiac defects第五頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)The Four Chamber View Heart fills one third of the chest第六頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)The Four Chamber View Apex points to the left (
5、45 degree angle)第七頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)The Four Chamber View Size of right chambers approximates left chambers第八頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)The Four Chamber View MV and TV move on real time imaging Ventricular septum symmetric第九頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)The Four Chamber View Portion of the atrial septum present (c
6、rus)第十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Left Ventricular Outflow TractIdentify: LV, RV, IV septum, aorta (normal caliber), +/- LA, +/- RAMedial wall of the ascending aorta merges with the top of the IV septum (most frequent location for VSD)Pathology: VSD, tetralogy of Fallot, transposition, truncus arteriosus第十一
7、頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Right Ventricular Outflow Tract Identify: branching of the main PA into right PA and ductus arteriosus (to desc Aorta), asc aorta in cross section, desc aorta to left of spine; verify PA crosses anterior to asc aorta Pathology: transposition, truncus arteriosus第十二頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(
8、英文版)SpineSpLeft AtriumRight AtriumLeft VentricleRight VentricleModerator BandForamen OvaleFour ChamberInterventricular Septum第十三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Left AtriumLeft VentricleRight VentricleAortaMitral Valve (closed)Aortic Valve (open)Interventricular SeptumLeft Ventricular Outflow Tract第十四頁,共七十四頁。胎兒的
9、循環(huán)系統(tǒng)(英文版)Right Ventricular Outflow TractRight AtriumRight VentricleMain Pulmonary ArteryRight Pulmonary ArteryDuctus ArteriosusAscending AortaAoTricuspid ValvePulmonic Valve (open)Descending AortadAoSp第十五頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Pitfalls: PseudoVSDWhen the IV septum parallels the US beam, resultant echo
10、drop out looks like VSDIV septum normally tapers near the AV valvesCorrected by changing the angle of viewIV septum parallels US beam (echo dropout)Changing Angle第十六頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版) Pericardial effusion ? NO! Normal amount fluid ( PA第三十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Tetralogy of FallotvideoCourtesy of Dr A
11、lfred Albahamedclick image to play video第三十一頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版) Endocardial Cushion Defect 5% of CHD Recur risk = 3% (1 sib), 10% (2 sibs), 1% (dad), 14% (mom) Freq assoc with other anomalies; strong assoc with Trisomy 21 Large defect at the crus of heart on four chamber view第三十二頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版
12、)Endocardial Cushion Defect Several types depend on how AV valves attach. Most common is type III, complete AV canal and common AV valve Endocardial cushions fail to fuse; cause defect in both the atrial and ventricular septae (AV canal)第三十三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Endocardial Cushion Defectatriavents第三十
13、四頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Endocardial Cushion Defect 4 Chamber View第三十五頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Endocardial Cushion Defect 4 Chamber ViewCourtesy of Dr Mark Skalansky第三十六頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Endocardial Cushion Defectatriavents第三十七頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Endocardial Cushion Defectventsatria第三十八頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)
14、Endocardial Cushion Defectvideoclick image to play video第三十九頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Transposition of Great VesselsD-type (“complete”) = heart tube loops to the right normal orientation of ventricles; but vessels malform (cyanosis)L-type (“congenitally corrected”) = heart tube loops to the left ventricul
15、ar inversion, but normal vessel orientation (no cyanosis)Childrens Virtual Hospital第四十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Transposition of the Great Vessels 4-6% of CHD Recurrence risk = 1.5% (1 sib), 5% (2 sibs) Association with excessive vitamin A Rarely associated with chromosome abnormalities 4第四十一頁,共七十四頁。胎兒的循環(huán)
16、系統(tǒng)(英文版)Transposition Great Vessels VSD (30-50%) Aorta arises anterior and to the right of PA; great vessels parallel each other 5 year survival (surgery) 90%第四十二頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Transposition Great VesselsCourtesy of Dr Mark Skalansky第四十三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Transposition Great VesselsvideoCourtes
17、y of Dr Alred Albafamedclick image to play video (video starts slowly)第四十四頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Hypoplastic Left Heart 2-4% of CHD 3 Hypoplasia of the LV; MV / AV stenosis or atresia Assoc with coarctation of aorta (80%) when AV atretic Hypothesis: low blood flow to LV causes hypoplasia第四十五頁,共七十四頁。胎兒的
18、循環(huán)系統(tǒng)(英文版)Hypoplastic Left Heart Causes hypoperfusion of coronary arts; CHF from ischemia Cyanosis at birth if LA to RA shunt not adequate Associated with chromosomal anomalies = 16% (one half from Trisomy 18 alone) 4第四十六頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版) Hypoplastic Left Heart4 Chamber View第四十七頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版
19、)Hypoplastic Right Heart Underdevelopment of right sided heart structures Hypoplasia of the RV and PA; RV wall thick; hypoplastic or incompetent TV; PV atresia Relies on patent ductus arteriosus for blood supply to lungs (PGE1) Tx = surgical sytemic to pulmonary shunt (Blalock Taussig Shunt)第四十八頁,共七
20、十四頁。胎兒的循環(huán)系統(tǒng)(英文版) Hypoplastic Right HeartSmall RV, thick wall第四十九頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Hypoplastic Right HeartSmall RVNotice themoderator band第五十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Hypoplastic Right Heart RVOT LVOTCaliber of PA aorta第五十一頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Double Outlet Right Ventricle 1% of CHD Recurrence risks not d
21、efined Both PA and at least half of the aorta originate from RV Karyotype abnormalities = 5%; including Trisomy 13,18 4第五十二頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Double Outlet Right Ventricle Associated with VSD, ascending aortic stenosis, pulmonic stenosis, AV abnormalities Complex embryologic changes involving bulbu
22、s cordis (RV), conus cordis (septum), and truncus arteriosus (great vessels)第五十三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Double Outlet Right VentricleBoth the PA and aorta (more than 50%) arise from the RV第五十四頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Double Outlet Right Ventriclevideoclick image to play video第五十五頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Truncus A
23、rteriosus 1% CHD Single arterial vessel “truncus” arises from the heart and supplies the coronary arteries, pulmonary and systemic circulations Recurrence risk = 1% (1 sib), 3% (2 sibs) 4第五十六頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Truncus Arteriosus Other associated pathology: VSD, abnormal trucal valve, ASD 20% overal
24、l mortality (surg 6mo to avoid pulmonary HTN) Differentiate from tetralogy of Fallot = no RVOT; look for origin of PAs from truncus第五十七頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Truncus Arteriosus第五十八頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Truncus Arteriosus第五十九頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Truncus ArteriosusFour Types (Van Praagh Classification) Main
25、 PA arises from truncal root and divides Both PAs arise from the truncal root separately Left PA supplied by collaterals from aortic arch1. Aortic arch interrupted; desc aorta supplied by ductus (10-15%)第六十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Ebstein Anomaly 1% CHD Recurrence risk = 1% (1 sib), 3% (2 sibs) Apical di
26、splacement of TV; small RV; RA grossly dilated because TV incompetent第六十一頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Ebstein Anomaly Assoc with ASD, WPW syndrome (30%), RV outflow obstruction (PS); CHF in utero from TR 1 Surgery to replace TV 1 ; arrhythmia is frequent after correction (dilated RA)第六十二頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)E
27、bstein Anomaly4 Chamber ViewTV第六十三頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Ebstein AnomalyCourtesy of Dr Mark Skalansky第六十四頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Ebstein AnomalyCourtesy of Dr Alfred Albafamedclick image to play video第六十五頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Coarctation of Aorta 2 / 1 (normal 1.8 / 1) Assoc w/ other cardiac defects = bicusp
28、id aortic valve, VSD, ASD 10% association with chromosomal anomalies (especially Turners)第六十八頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Coarctation of Aorta第六十九頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)Coarctation of Aortavideoclick image to play video第七十頁,共七十四頁。胎兒的循環(huán)系統(tǒng)(英文版)ReferencesDiagnostic Ultrasound of Fetal Anomalies: Text and Atlas, Nyberg DA, Mahony BS, Pretorius DH, 1990, Year Bood Medical Publisher, Inc.Sonography of the Normal Fetal Heart: A Practical Approach, Frates MC, AJR 1999; 173: 1363-70.Prenatal Diagnosis of Congenital Card
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