藥理學課件南開大學影響自體活性物質(zhì)的藥物教學文案

1、藥理學課件南開大學影響自體活性物質(zhì)的藥物Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonistsHistamine Together with endogenous peptides, prostaglandins and leukotrienes, and cytokines, they are sometimes called autacoids or local hormones bronch

2、oconstriction and contraction of intestinal S.M. Expand blood vessel Permeabilitystimulate sensory nerve endings Cause gastric acid, gastric pepsin and intrinsic factor production. Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate. bronchoconstriction and contrac

3、tion of intestinal S.M. Expand blood vessel Permeabilitystimulate sensory nerve endings Cause gastric acid, gastric pepsin and intrinsic factor production. Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate. Intradermal injection of histamine causes a characterist

4、ic wheal-and-flare response, which involves an erythema, an edematous wheal and a red irregular flare surrounding the wheal. To be used in testing gastric acid secretion and diagnosis of leprosy.Decrease of gastric acid can be seen in malignant anemia and true achlorhydiaHistamine and Antihistamine

5、AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonistsHistamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonistsFirst-generation blockersSecond-generation blockers urapidly absorbed oral

6、lyuwidely distributed and the first-generation drugs enter the CNS readily.uMost metabolized in the liver uMost excreted from the kidney bronchoconstriction and contraction of intestinal S.M. Expand blood vessel Permeabilitystimulate sensory nerve endings Cause gastric acid, gastric pepsin and intri

7、nsic factor production. Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate. Sedation, antimuscarinic action, drug allergy, cardiac arrhythmias (astemizole) and possible teratogenic effects.Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antag

8、onistsH1 receptor antagonistsH2 receptor antagonists bronchoconstriction and contraction of intestinal S.M. Expand blood vessel Permeabilitystimulate sensory nerve endings Cause gastric acid, gastric pepsin and intrinsic factor production. Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.Gastrointestinal reaction,CNS react