Cecropin-A-TFA _Bacterial 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECecropin A TFACat. No.: HY-P1539A分式: CHNOF分量: 4117.8作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 50 mg/mL (12.14 mM)* means soluble, but saturation unkno

2、wn.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 0.2428 mL 1.2142 mL 2.4285 mL5 mM 0.0486 mL 0.2428 mL 0.4857 mL10 mM 0.0243 mL 0.1214 mL 0.2428 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Cecropin A TFA是由 37 個(gè)氨基酸殘基構(gòu)成的線性抗菌肽，從 Hyalaphora cecropia pupae 得到，具有抗菌、抗炎 1和抗癌作 2

3、。體外研究Cecropin A (10, 20, 30, 40 and 50 M) induces cytotoxicity on HL-60 cells in a dose-dependent manner.Cecropin A induces apoptosis independent of caspase activation 1.Cecropin A shows good antibacterial activity against both multidrug-resistant Gram-negative bacteria such asA. baumanii (MDRAB) an

4、d multidrug-resistant P. aeruginosa (MDRPA) with IC50s of 0.5-1 M.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemECecropin A (0.1, 0.25 M) exhibits anti-inflammatory activities. Cecropin A (25 M) effectively suppresses theexpression of mTNF-, mIL-1, and mMIP-2 mRNA and slightly inhibits the express

5、ion of mMIP-1 mRNA.Cecropin A also effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduced theexpression of COX-2 2.REFERENCES1. Cern JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells.Peptides. 2010 Aug;31(8):1494-503.2. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3