BMS-986158 _Epigenetic Reader Domain 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBMS-986158Cat. No.: HY-101567CAS No.: 1800340-40-2分式: CHNO分量: 495.62作靶點: Epigenetic Reader Domain作通路: Epigenetics儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 1 mg/mL (2.02 mM; Need ultra

2、sonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0177 mL 10.0884 mL 20.1767 mL5 mM - - -10 mM - - -請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 BMS-986158種溴結構域和額外末端結構域 (BET) 蛋抑制劑。IC50 & Target BET 1體外研究BMS-986158 is an inhibitor of the bromodomain (BRD) and extra-term

3、inal domain (BET) family of proteins,with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and1/2 Master of Small Molecules 您邊的抑制劑師www.MedCh

4、emEacetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth 2.REFERENCES1. von Schaper E. Roche bets on bromodomains. Nat Biotechnol. 2016 Apr;34(4):361-2.2. BET Inhibitor BMS-986158.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: